The Utility of Indigo Carmine and Lipiodol Mixture for Preoperative Pulmonary Nodule Localization before Video-Assisted Thoracic Surgery

Hasegawa, Takaaki; Kuroda, Hiroaki; Sato, Yozo; Matsuo, Keitaro; Sakata, Shozo; Yashiro, Hideki; Sakakura, Noriaki; Mizuno, Tetsuya; Arimura, Takaaki; Yamaura, Hidekazu; Murata, Shinichi; Imai, Yugo; Sakao, Yukinori; Inaba, Yoshitaka

doi:10.1016/j.jvir.2018.08.024

Cited by 27 publications

(41 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TDI using indigo carmine might be another option to make small nodules identifiable by direct vision (1,(8)(9)(10). Clinically, TDI has been frequently performed in these days, which let the risk of complications decreased, such as pneumothorax, hemothorax, and pleuritic chest pain.…”

Section: Discussionmentioning

confidence: 99%

“…With the methods that use transthoracic percutaneous localization, the occurrence of post-procedural complications, such as pneumothorax or bleeding, is possible (1,3,6). In the case of transbronchial dye injection (TDI) via bronchoscopy, the aforementioned Original Article complications do not occur based on several articles (7,8); however, there can be difficulties with dye visualization through the thoracoscope depending on early disappearance of the dye due to diffusion before field exposure (1,(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of factors affecting the visualization of dye after transbronchial dye injection: an animal experiment

et al. 2020

View full text Add to dashboard Cite

Background: Since peripheral lung lesions can be frequently visualized on computed tomography (CT), various methods of localization for thoracoscopic surgery have been developed. In the case of transbronchial dye injection (TDI), there can be difficulties with dye visualization through the thoracoscope depending on early disappearance of the dye due to diffusion before field exposure. Herein, we performed an animal experiment to determine the appropriate dye amount and the duration of visualization.Methods: Twelve pigs were experimented as following four groups (n=3): group 1 received 0.6 mL of dye; group 2 as 0.8 mL; and group 3 as 1.0 mL, all followed by 2.0 mL of air injection and group 4, with 1.0 mL of dye followed no air injection to evaluate the utility of air injection. The detection, the peak time, the washout time were measured. Results:The mean detection times, the peak time, and the mean wash-out times for 0.6, 0.8, and 1.0 mL of dye were not significantly different (P=0.195, 0.092, 0.06). However, regardless of the injected amount, it usually lasts in 2 hours. Comparing with non-air injection group, the peak time and wash-out time were statistically significantly different in injected group; P=0.07 and 0.001. Conclusions:The marking could be identified clearly at about 2 hours after TDI regardless of the amount of indigo carmine injected. However, in cases with longer duration to exposure, especially in cases with severe adhesions, it might be necessary to discover the mixture of dye which will last longer for visualization of lung nodules.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of factors affecting the visualization of dye after transbronchial dye injection: an animal experiment

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The successful targeting rate, localization rate, VATS rate, and procedure-related complications rate were calculated based on the total number of the nodules [11,22]. Note: " ★ " The emphysema region was around the needle insertion pathway. "…”

Section: Assessmentmentioning

confidence: 99%

The utility of simultaneous CT-guided localization for multiple pulmonary nodules using microcoil before Video-Assisted Thoracic Surgery

Sun

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: To evaluate the feasibility and safety of microcoil in simultaneous localization for multiple pulmonary nodules before video-assisted thoracic surgery (VATS).Methods: Twenty-eight consecutive patients (26 two-nodule, 2 three-nodule; totally 58 nodules; Group A) underwent simultaneous CT-guided localization for multiple pulmonary nodules before VATS using microcoil. Successful targeting, localization, and VATS were defined as implantation of microcoil at the target site on CT image obtained immediately after the marking procedure, visualization of nodule location, and complete resection of the target nodule with adequate margin, respectively. Meanwhile, the clinical characteristics, localization procedure-related variables of the nodules and procedure-related complication in group A were also assessed and compared with those in a control group (221 single-localization procedures in 221 patients; Group B). Results: The similar rates of success targeting, localization and VATS were observed in group A and B (96.6% vs 98.2%; 91.4% vs 91.0%; 100% vs 99.1%). Although the rate of overall complications (including localized pneumothorax and intrapulmonary hemorrhage) was a bit higher in group A than that in group B (32.8% vs 30.8%, p=0.771), only minor complications were observed in the subjects of the two groups with no need for further treatment. In addition, the duration of simultaneous localization procedures was significantly longer than that of single localization ones (24±7.5 vs 13±6 min, p<0.001).Conclusions: CT-guided simultaneous microcoil localization for multiple pulmonary nodules before VATS was clinical feasible and safe with acceptable increasing the procedure time. Compared with localization for a single pulmonary nodule, simultaneous microcoil localizations for multiple nodules were prone to the occurrence of pneumothorax and hemorrhage. However, no statistically significant differences were observed between the two groups.

show abstract

“…The successful targeting rate, localization rate, VATS rate, and procedure-related complications rate were calculated based on the total number of the nodules [11,21]. Successful targeting was de ned as implantation of microcoil at the target site adjacent to a nodule on CT image which was obtained immediately after the marking procedure and the rate was calculated as follows: (number of successful targeting procedures/number of all localization procedures in each group)x100; successful localization was de ned as detection of nodule location and the rate was calculated as follows: ([number of successful targeting procedures-number of dislodgements or misses under the thoracoscope]/number of all localization procedures in each group)x100; successful VATS was de ned as a complete resection of the target nodule with adequate margin and the rate was calculated as follows: ([number of successful VATS /number of all localization procedures in each group)x100.…”

Section: Assessmentmentioning

confidence: 99%

The utility of simultaneous CT-guided localization for multiple pulmonary nodules using microcoil before Video-Assisted Thoracic Surgery

Sun

et al. 2021

Preprint

View full text Add to dashboard Cite

Background: To evaluate the feasibility and safety of microcoil in simultaneous localization for multiple pulmonary nodules before video-assisted thoracic surgery (VATS).Methods: Twenty-eight consecutive patients (26 two-nodule, 2 three-nodule; 58 nodules in total; Group A) underwent simultaneous CT-guided localization of multiple pulmonary nodules before VATS using microcoil. Successful targeting, localization, and VATS were defined as implantation of microcoil at the target site on CT image which was obtained immediately after the marking procedure, visualization of nodule location, and complete resection of the target nodule with adequate margin, respectively. Meanwhile, the clinical characteristics, localization procedure-related variables of the nodules and procedure-related complications in group A were also assessed and compared with those in a control group (221 single-localization procedures in 221 patients; Group B). Results: Similar rates of successful targeting, localization and VATS were observed in group A and B (96.6% vs 98.2%; 91.4% vs 91.0%; 100% vs 99.1%). Although the rate of overall complications (including localized pneumothorax and intrapulmonary hemorrhage) was a bit higher in group A than that in group B (32.8% vs 30.8%, p=0.771), only minor complications were observed in the subjects of the two groups with no need for further treatment. In addition, the duration of simultaneous localization procedures was significantly longer than that of single localization (24±7.5 vs 13±6 min, p<0.001).Conclusions: CT-guided simultaneous microcoil localization for multiple pulmonary nodules before VATS was clinically feasible and safe with acceptable increase in the procedure time. Compared with localization for a single pulmonary nodule, simultaneous microcoil localizations for multiple nodules were prone to pneumothorax and hemorrhage. However, no statistically significant differences were observed between the two groups.

show abstract

The Utility of Indigo Carmine and Lipiodol Mixture for Preoperative Pulmonary Nodule Localization before Video-Assisted Thoracic Surgery

Cited by 27 publications

References 34 publications

Evaluation of factors affecting the visualization of dye after transbronchial dye injection: an animal experiment

Evaluation of factors affecting the visualization of dye after transbronchial dye injection: an animal experiment

The utility of simultaneous CT-guided localization for multiple pulmonary nodules using microcoil before Video-Assisted Thoracic Surgery

The utility of simultaneous CT-guided localization for multiple pulmonary nodules using microcoil before Video-Assisted Thoracic Surgery

Contact Info

Product

Resources

About