The Utility of Fundus Fluorescein Angiography in Neuro-Ophthalmology

Littlewood, Revelle; Mollan, Susan P; Pepper, Irene M; Hickman, Simon J.

doi:10.1080/01658107.2019.1604764

Cited by 23 publications

(13 citation statements)

References 108 publications

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“…However, nowadays OCT angiography (OCTA) provides fast and non-invasive imaging of the retinal vessels. Although fluorescein angiography is still used in certain cases 7 , it has been largely displaced by OCTA.…”

Section: Introductionmentioning

confidence: 99%

Acute monocular oligemia in a patient with migraine with aura demonstrated using OCT-angiography: A case report

Martín-Moro

Porta‐Etessam

Fuente

et al. 2020

European Journal of Ophthalmology

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Introduction: Migraine is one of the most common causes of transient visual loss. Optical coherence tomography angiography (OCTA) provides fast and non-invasive imaging of the retinal vessels. We report the first case of monocular retinal oligemia demonstrated using OCTA during a migraine attack with aura. Case description: A 27-year-old man with a previous history of migraine with visual aura was seen in the emergency room due to acute left hemicranial pain with positive visual symptoms in his right eye. The patient reported a blue stain in his right eye. Optical coherence tomography angiography (OCT-A) showed an extensive area of hypoperfusion in the macular region of his right eye. Forty-eight hours later visual symptoms had improved and the OCT-A showed a significant reduction in the area of hypoperfusion. Seven days later the patient was asymptomatic and retinal perfusion had returned to normal values. Conclusion: Monocular involvement suggests that these retinal vascular changes are independent from cerebral vascular changes, supporting the hypothesis of selective retinal ganglion cell layer spreading depression as the possible cause of some cases of retinal migraine.

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Section: Introductionmentioning

confidence: 99%

Acute monocular oligemia in a patient with migraine with aura demonstrated using OCT-angiography: A case report

Martín-Moro

Porta‐Etessam

Fuente

et al. 2020

European Journal of Ophthalmology

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“…Fluorescein angiography (FFA) relies on fluorescence to evaluate the vasculature of the retina. FFA can visualize dynamic effects of vascular filling as well as blood vessel leakage due to endothelial damage, inflammation, and neovascularization or raised ICP [ 40 ]. Mild to moderate degrees of papilledema must be present to detect changes in FFA.…”

Section: Reviewmentioning

confidence: 99%

Optic Disc Edema and Elevated Intracranial Pressure (ICP): A Comprehensive Review of Papilledema

Reier¹,

Fowler²,

Arshad³

et al. 2022

Cureus

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Papilledema is a swelling of the optic disc secondary to elevated intracranial pressure (ICP). We analyzed 79 peer-review journal articles and provided a concise summary of the etiology, epidemiology, pathophysiology, clinical presentation, evaluation, natural history, differential diagnosis, treatment, and prognosis of papilledema. Only studies written in English with the full text available were included. Although many etiologies of papilledema exist, idiopathic intracranial hypertension is the most common and, thus, a large focus of this review.

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“…OCTA also has certain disadvantages, namely imaging artifacts and inability to detect dynamic vessel related changes such as leakage or venous sheathing ( 92 ). There are yet no consensus quality control criteria similar to what has been achieved for OCT ( 30 ).…”

Section: Advantages and Disadvantages Of Octamentioning

confidence: 99%

Optical Coherence Tomography Angiography (OCTA) in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

et al. 2020

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Vascular changes are increasingly recognized as important factors in the pathophysiology of neuroinflammatory disease, especially in multiple sclerosis (MS). The relatively novel technology of optical coherence tomography angiography (OCTA) images the retinal and choroidal vasculature non-invasively and in a depth-resolved manner. OCTA provides an alternative quantitative measure of retinal damage, by measuring vascular density instead of structural atrophy. Preliminary results suggest OCTA is sensitive to retinal damage in early disease stages, while also having less of a “floor-effect” compared with commonly used OCT metrics, meaning it can pick up further damage in a severely atrophied retina in later stages of disease. Furthermore, it may serve as a surrogate marker for vascular pathology in the central nervous system. Data to date consistently reveal lower densities of the retinal microvasculature in both MS and neuromyelitis optica spectrum disorder (NMOSD) compared with healthy controls, even in the absence of prior optic neuritis. Exploring the timing of vascular changes relative to structural atrophy may help answer important questions about the role of hypoperfusion in the pathophysiology of neuroinflammatory disease. Finally, qualitative characteristics of retinal microvasculature may help discriminate between different neuroinflammatory disorders. There are however still issues regarding image quality and development of standardized analysis methods before OCTA can be fully incorporated into clinical practice.

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The Utility of Fundus Fluorescein Angiography in Neuro-Ophthalmology

Cited by 23 publications

References 108 publications

Acute monocular oligemia in a patient with migraine with aura demonstrated using OCT-angiography: A case report

Acute monocular oligemia in a patient with migraine with aura demonstrated using OCT-angiography: A case report

Optic Disc Edema and Elevated Intracranial Pressure (ICP): A Comprehensive Review of Papilledema

Optical Coherence Tomography Angiography (OCTA) in Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder

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