The utility of CD83, fascin and CD23 in the differential diagnosis of primary mediastinal large B-cell lymphoma versus classic Hodgkin lymphoma

Aladily, Tariq N.; Mansour, Ahmad T.; Alsughayer, Anas M.; Sughayer, Maher A.; Medeiros, L. Jeffrey

doi:10.1016/j.anndiagpath.2019.04.009

Cited by 12 publications

(12 citation statements)

References 13 publications

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“…It has been suggested that mediastinal NSCHL, PMBL, and MGZL represent a biologic continuum based on the morphology and phenotype, which may hypothetically be driven by lineage plasticity in common thymic precursor cells . PD‐L1 alteration and PD‐L1 expression are now considered a defining feature of CHL, playing important role in shaping the immunosuppressive microenvironment in CHL through reversible inhibition of T‐cell activation and proliferation .…”

Section: Discussionmentioning

confidence: 99%

“…Immunohistochemistry is required for the differential diagnosis of mediastinal lymphomas that overlap in morphologic and biologic properties. Investigation of various markers have resulted in few consensus panels . Notably, CD274/programmed cell death ligand 1 (PD‐L1) positivity on tumor cells is characteristic of CHL, and is less frequently exhibited by PMBL .…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic utility of programmed cell death ligand 1 (clone SP142) in mediastinal composite lymphoma: A report of two cases

Sakakibara

Kohno

Iwakoshi

et al. 2020

Pathology International

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Composite lymphoma is a well‐known diagnostic entity exhibiting the synchronous occurrence of two or more distinct types of lymphomas in the same specimen. Here we report two patients, a 14‐year‐old female (Case 1) and a 45‐year‐old male (Case 2), with mediastinal composite lymphoma, comprising nodular sclerosis classic Hodgkin lymphoma (NSCHL) and primary mediastinal large B‐cell lymphoma (PMBL). Both patients had a mediastinal mass, and manifested two different histologic components in the same biopsy, one characteristic of NSCHL and the other PMBL. The NSCHL areas included Hodgkin and Reed–Sternberg (HRS) cells with typical immunophenotypic features (CD30‐positive and CD20‐negative), whereas the sheets of large tumor cells characteristic of PMBL were strongly and uniformly CD20‐positive. Interestingly, although both cases showed neoplastic PD‐L1 (nPD‐L1) positivity on the HRS cells of NSCHL, they differed regarding nPD‐L1 expression on the PMBL tumor cells. In Case 1, the nPD‐L1‐negative PMBL component was anatomically situated outside the NSCHL lesion. On the other hand, in Case 2, the nPD‐L1‐positive PMBL component was characterized by transitional or continuous areas with the NSCHL component. These findings suggested that nPD‐L1 expression may define two subtypes of PMBL that are more similar to or distinct from classic Hodgkin lymphoma.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnostic utility of programmed cell death ligand 1 (clone SP142) in mediastinal composite lymphoma: A report of two cases

Sakakibara

Kohno

Iwakoshi

et al. 2020

Pathology International

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“…The lymphoma cells are positive for pan-B-cell antigens, CD10 (~25%), BCL-6 (~95%), MUM-1/IRF-4 (~95%), c-MYC (~65%), CD83 (~40%), fascin (~30%), and BCL-2 (~65%). 51,52 CD23 (Fig. 5B) is positive in 70-95% and CD30 is positive in approximately 80% of cases.…”

Section: Immunophenotypementioning

confidence: 93%

“…5B) is positive in 70-95% and CD30 is positive in approximately 80% of cases. 52 OCT-2 and BOB.1 are usually positive. 53 CD5 and CD138 are negative.…”

Section: Immunophenotypementioning

confidence: 99%

Diffuse large B-cell lymphoma variants: an update

et al. 2020

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“…The characteristic feature of PMBL is a diffuse growth pattern of medium to large-sized neoplastic cells surrounded by a variable degree of sclerosis and collagen band (compartmentalization) mimicking nodules [9,31]. The lymphoma cells have, characteristically, round or pleomorphic nuclei and clear, pale, or slightly basophilic cytoplasm [9,31]. RSLCs may be observed [26].…”

Section: Histological Findings and Immunophenotypementioning

confidence: 99%

Hodgkin Reed–Sternberg-Like Cells in Non-Hodgkin Lymphoma

et al. 2020

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Reed–Sternberg cells (RSCs) are hallmarks of classic Hodgkin lymphoma (cHL). However, cells with a similar morphology and immunophenotype, so-called Reed–Sternberg-like cells (RSLCs), are occasionally seen in both B cell and T cell non-Hodgkin Lymphomas (NHLs). In NHLs, RSLCs are usually present as scattered elements or in small clusters, and the typical background microenviroment of cHL is usually absent. Nevertheless, in NHLs, the phenotype of RSLCs is very similar to typical RSCs, staining positive for CD30 and EBV, and often for B cell lineage markers, and negative for CD45/LCA. Due to different therapeutic approaches and prognostication, it is mandatory to distinguish between cHL and NHLs. Herein, NHL types in which RSLCs can be detected along with clinicopathological correlation are described. Moreover, the main helpful clues in the differential diagnosis with cHL are summarized.

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The utility of CD83, fascin and CD23 in the differential diagnosis of primary mediastinal large B-cell lymphoma versus classic Hodgkin lymphoma

Cited by 12 publications

References 13 publications

Diagnostic utility of programmed cell death ligand 1 (clone SP142) in mediastinal composite lymphoma: A report of two cases

Diagnostic utility of programmed cell death ligand 1 (clone SP142) in mediastinal composite lymphoma: A report of two cases

Diffuse large B-cell lymphoma variants: an update

Hodgkin Reed–Sternberg-Like Cells in Non-Hodgkin Lymphoma

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