The utility of anti-SOX2 antibodies for cancer prediction in patients with paraneoplastic neurological disorders

Maddison, Paul; Titulaer, Maarten J.; Verschuuren, Jan J.; Gozzard, Paul; Lang, Bethan; Irani, Sarosh R.; Sabater, Lidia; Graus, Francesc; Murray, Andrea; Chapman, Caroline

doi:10.1016/j.jneuroim.2018.11.003

Cited by 14 publications

(8 citation statements)

References 39 publications

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“…SOX2 antibodies were detectable in 61% of patients with Lambert‐Eaton myasthenic syndrome (LEMS)‐SCLC, and in other paraneoplastic disorders, such as opsoclonus‐myoclonus and paraneoplastic cerebellar degeneration, only when there was an underlying SCLC. SOX2 antibodies are specific (>90%) markers for SCLC 11,12 . However, SOX2 antibodies were not detected in our study.…”

Section: Discussioncontrasting

confidence: 79%

“…SOX2 antibodies are specific (>90%) markers for SCLC. 11,12 However, SOX2 antibodies were not detected in our study. A novel antibody biomarker of neurologic paraneoplastic autoimmunity specific for phosphodiesterase 10A (PDE10A) defines a novel rare neurologic autoimmune syndrome and expands the spectrum of diagnosable paraneoplastic CNS disorders.…”

Section: Discussioncontrasting

confidence: 79%

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Clinical characteristics of paraneoplastic neurological syndrome related to different pathological lung cancers

Wang

Jiang

et al. 2021

Thoracic Cancer

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Background Paraneoplastic syndrome is a distant effect caused by malignant tumors, which is related to the production of cellular immune response. The nervous system is the most common involved system of paraneoplastic syndrome. It is easy to be misdiagnosed. Lung cancer is the most common cancer relating to paraneoplastic neurological syndrome (PNS). Method This study retrospectively analyzed clinical data of patients with the combination of PNS and lung cancer between January 2005 and March 2021 at Qilu Hospital of Shandong University, China. Results A total of 111 patients were diagnosed with lung cancer complicated with PNS. A total of 95 (85.6%) cases had neurological symptoms as the first symptom. Sixty‐three cases had the pathological results. A total of 43 (68.3%) of small cell lung cancer (SCLC) were diagnosed. PNS patients diagnosed with SCLC included peripheral neuropathy (15 cases, 34.9%). PNS patients diagnosed with non‐small cell lung cancer (NSCLC) included peripheral neuropathy (6 cases, 30%) and limbic encephalitis (6 cases, 30%). Anti‐Hu is popular in patients with SCLC (12 cases, 42.9%) and NSCLC (6 cases, 40%). Conclusions Most patients with PNS had neurological symptoms as the first symptom. It was more common in males. It had a higher incidence in SCLC. Peripheral neuropathy was the most common PNS associated with SCLC, followed by Lambert‐Eaton syndrome. Peripheral neuropathy and limbic encephalitis were the most common PNS associated with NSCLC. Anti‐Hu is the most common antibodies both in SCLC and NSCLC. Tumor markers do not have significant difference between different pathological types.

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Section: Discussioncontrasting

confidence: 79%

Section: Discussioncontrasting

confidence: 79%

Clinical characteristics of paraneoplastic neurological syndrome related to different pathological lung cancers

Wang

Jiang

et al. 2021

Thoracic Cancer

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“…Many PNSs are associated with specific antineuronal antibodies, but the diversity is considerable such that no single antibody is associated with only one type of neurological presentation or underlying tumour ( 28 ). For example, anti-Hu antibody are found in patients presenting with a range of PNS such as encephalomyelitis, subacute sensory neuropathy (SSN), limbic encephalitis (LE), paraneoplastic cerebellar degeneration (PCD), but also in patients with LEMS where the presence of Hu antibodies may be a marker of an underlying small cell lung cancer (SCLC) ( 28 ). As for tumors, anti-Hu antibody are mainly associated with SCLC, however, there is also reports that it is present in neuroblastoma, prostate cancer and sarcoma, rarely no tumor is found ( 29 , 30 ).…”

Section: Significance Of Paraneoplastic Antibodiesmentioning

confidence: 99%

Detection of paraneoplastic antibodies and their significance in paraneoplastic neurologic syndromes: a narrative review

Li¹,

Guo²,

Wang³

2023

Ann Transl Med

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Background and Objective: Paraneoplastic neurological syndromes (PNS) are a group of rare syndromes associated with immunopathological process and tumors. Paraneoplastic autoantibodies are important for the diagnosis of PNS and for searching for underlying tumors. With the development of detection methods and discovery of new autoantibodies, the 2004 guidelines on PNS have recently been updated by a worldwide PNS-Care expert group. For clinicians, proper testing methods and testing results explanation are important for the diagnosis and treatment of PNS. This review aims to review the detection of paraneoplastic autoantibodies and the significance of testing results. Methods:We summarize the studies on detection methods, association of autoantibodies and PNS or tumors, particularly the guidelines of PNS.

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“…For example, in paraneoplastic pemphigus, isolated autoantibodies recognized more distinct autoantigens, different epitopes on the same autoantigen, and were primarily of subclass IgG1 and IgG2 when compared to pemphigus vulgaris which had primarily IgG4 autoantibodies ( 91 ). A combination of autoantibodies to tumor associated antigens as well as autoantibodies to paraneoplastic syndrome associated antigens have been investigated as biomarkers in lung cancer and ovarian cancer ( 92 , 93 ). Despite this, there has been little direct evidence for linkage of the same self-antigen expression by the tumor and the target autoimmune tissue.…”

Section: Role In Paraneoplastic Syndromes Autoimmunity and Checkpoint...mentioning

confidence: 99%

Clonal redemption of B cells in cancer

McCaw,

Lofftus,

Crompton

2023

Front. Immunol.

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Potentially self-reactive B cells constitute a large portion of the peripheral B cell repertoire in both mice and humans. Maintenance of autoreactive B cell populations could conceivably be detrimental to the host but their conservation throughout evolution suggests performance of a critical and beneficial immune function. We discuss herein how the process of clonal redemption may provide insight to preservation of an autoreactive B cell pool in the context of infection and autoimmunity. Clonal redemption refers to additional recombination or hypermutation events decreasing affinity for self-antigen, while increasing affinity for foreign antigens. We then review findings in murine models and human patients to consider whether clonal redemption may be able to provide tumor antigen-specific B cells and how this may or may not predispose patients to autoimmunity.

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The utility of anti-SOX2 antibodies for cancer prediction in patients with paraneoplastic neurological disorders

Cited by 14 publications

References 39 publications

Clinical characteristics of paraneoplastic neurological syndrome related to different pathological lung cancers

Clinical characteristics of paraneoplastic neurological syndrome related to different pathological lung cancers

Detection of paraneoplastic antibodies and their significance in paraneoplastic neurologic syndromes: a narrative review

Clonal redemption of B cells in cancer

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