The Utility of Acute Physiology and Chronic Health Evaluation II Scores for Prediction of Mortality among Intensive Care Unit (ICU) and Non-ICU Patients with Methicillin-Resistant <i>Staphylococcus aureus</i> Bacteremia

Stevens, Vanessa; Lodise, Thomas P.; Tsuji, Brian T.; Stringham, Meagan; Butterfield, Jill M.; Ashley, Elizabeth Dodds; Brown, Kristen; Forrest, Alan; Brown, Jack

doi:10.1086/665731

Cited by 23 publications

(14 citation statements)

References 38 publications

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“…It was discovered in the study that each research object is a unique individual and the intensive care experience differs from that of others. A statistic analysis on the data on such unique individuals indicated that the patients in mechanical ventilation experienced moderate and higher level of intensive care experience, which was consistent with the previous results of researches with westerners as the research objects [16][17]. Baudry has reported cases mental disturbance arising from ICU care and proposed the concept of intensive care syndrome [18].…”

Section: Discussionsupporting

confidence: 83%

Research on Intensive Care Experiences of Patients in Mechanical Ventilation

Hu¹,

Ye²,

Ji³

2019

AJBIO

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To quantitatively analyse conditions of intensive care experiences and influencing factors of patients. A database was established, it can be seen from the overall experience index that in the SD dimensionality, 46.11% patients have highly bad experiences and 86.11% patients have moderate and highly bad experiences in total plus the patients with moderate scores; in ET dimensionality, 32.78% patients have highly bad experiences and 67.22% patients have moderate and highly bad experiences in total plus the patients with moderate scores; in TII dimensionality, 73.88% patients have moderate and highly bad experiences. L ICU and L MV of patients and overall GEI and various factor scores exhibit a significant positive correlation (P<0.05) indicating that the longer the time of mechanical ventilation treatment and length of stay in ICU, the more bad experiences the patients will have; patients' APACHE scores and the overall GEI, dimensionality ET, ACF and TII exhibit a positive correlation (P<0.05) indicating the severer the disease is, the more bad experiences on intensive care the patient will have. Mechanical ventilation duration, disease severity degrees, marital status and age are the major factors influencing intensive care experiences of patients in mechanical ventilation.

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Section: Discussionsupporting

confidence: 83%

Research on Intensive Care Experiences of Patients in Mechanical Ventilation

Hu¹,

Ye²,

Ji³

2019

AJBIO

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“…The degree of patient comorbidity was quantified by using the Charlson comorbidity index (36). Severity of illness was quantified by using the APACHE II score, using the worst parameters within 24 h of the index MRSA blood culture (37,38). The source(s) of MRSA BSI was based on the treating physicians' notes and available clinical and diagnostic data.…”

Section: Methodsmentioning

confidence: 99%

Multicenter Observational Study of Ceftaroline Fosamil for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections

Zasowski

Trinh

Claeys

et al. 2017

Antimicrob Agents Chemother

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Novel therapies for methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infection (BSI) are needed in the setting of reduced antibiotic susceptibilities and therapeutic failure. Ceftaroline is a cephalosporin antibiotic with MRSA activity. Although not FDA approved for MRSA BSI, ceftaroline has generated much interest as a potential treatment option. However, detailed descriptions of its use in this setting remain limited. To address this, we conducted a retrospective, multicenter, observational study of adult patients with MRSA BSI treated with at least 72 h of ceftaroline from 2011 to 2015. Safety outcomes were examined in the overall cohort, while efficacy outcomes were examined among patients who had not cleared their BSI prior to ceftaroline initiation. Data were also stratified by ceftaroline monotherapy or combination therapy. Predictors of clinical failure on ceftaroline treatment were also sought. Overall, 211 patients were included in the safety population; Clostridium difficile infection, rash, and neutropenia occurred in 6 patients (2.8%), 7 patients (3.3%), and 3 patients (1.4%), respectively. Clinical success was observed in 86 (68.3%) of the 126 patients included in the efficacy population. The monotherapy and combination therapy subgroups had similar proportions of patients experiencing success (69.7 and 64.9%, respectively). The median BSI durations post-ceftaroline treatment were 2 days (interquartile range, 1 to 4 days) for monotherapy and 3 days (interquartile range, 1.5 to 5 days) for combination therapy. Higher acute physiology and chronic health evaluation II scores and comorbid malignancy independently predicted treatment failure. Ceftaroline appears effective for MRSA BSI as both monotherapy and combination therapy. However, comparative studies are needed to further delineate the role of ceftaroline in MRSA BSI treatment.

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“…The need for mechanical ventilation, intensive care unit (ICU) admission, and APACHE II score were assessed on the day the index culture was collected (15). The Charlson comorbidity index (CI) determined the extent of comorbid illnesses (16).…”

mentioning

confidence: 99%

Ertapenem-Containing Double-Carbapenem Therapy for Treatment of Infections Caused by Carbapenem-Resistant Klebsiella pneumoniae

Cprek

Gallagher

2016

Antimicrob Agents Chemother

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We describe outcomes of patients with infections with carbapenem-resistant Klebsiella pneumoniae (CRKP) who received ertapenem-containing double-carbapenem therapy (ECDCT). Clinical success was observed in 7/18 (39%) patients overall: bloodstream infections, 3/7 (43%); pneumonia, 1/5 (20%); intraabdominal infections, 0/2 (0%); urinary tract infections, 2/3 (67%); and a skin and skin structure infection, 1/1 (100%). Microbiologic success was observed in 11/14 (79%) evaluable patients; 5/18 (28%) patients died. ECDCT may be effective for CRKP infections with limited treatment options.

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The Utility of Acute Physiology and Chronic Health Evaluation II Scores for Prediction of Mortality among Intensive Care Unit (ICU) and Non-ICU Patients with Methicillin-Resistant Staphylococcus aureus Bacteremia

Abstract: The APACHE II score may be a valid tool to control for confounding or for the prediction of death among ICU and non-ICU patients with MRSA bacteremia.

Cited by 23 publications

References 38 publications

Research on Intensive Care Experiences of Patients in Mechanical Ventilation

Research on Intensive Care Experiences of Patients in Mechanical Ventilation

Multicenter Observational Study of Ceftaroline Fosamil for Methicillin-Resistant Staphylococcus aureus Bloodstream Infections

Ertapenem-Containing Double-Carbapenem Therapy for Treatment of Infections Caused by Carbapenem-Resistant Klebsiella pneumoniae

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