The utility of 18F-fluorocholine PET/CT in the imaging of parathyroid adenomas

Abstract

However, for a minimally invasive approach a precise localisation is required.Several imaging modalities have been proposed for preoperative detection and localisation of hyperfunctioning parathyroid glands. Neck ultrasound (US) and 99m Tc-methoxy-isobutyl-isonitrile ( 99m Tc-MIBI) scintigraphy are currently the most frequently used methods [6]. US, the most readily available and least expensive one, shows rather limited sensitivity, varying from 57% to 76%. It also fails to detect ectopic parathyroid adenomas [7]. On the other hand, ectopic parathyroid tissue can be detected in scintigraphy, which is reported to have a sensitivity of about 60%. It might be increased to 92% when single photon emission computed tomography/computed tomography (SPECT/CT) is performed [8][9][10]. Currently, it is considered the method of choice for the detection of parathyroid adenomas [2,4].Contemporary research suggests that 18 F-fluorocholine (FCH) positron emission tomography/computed

Clinical, Biochemical, and Sonographic Factors Influencing Performance of Parathormone Washout Measurement vs. 99mTc-MIBI Scintigraphy in the Preoperative Diagnostics of Parathyroid Adenomas

“…Interestingly, even higher values of diagnostic accuracy have been obtained with PET-CT using 18 F-choline, even for small Pas [3,19]. In a recent meta-analysis, the sensitivity of 18 F-choline PET was equal to 95%, with a very high PPV of 97%.…”

“…The precise preoperative visualization of parathyroid adenoma (PA) is mandatory for patients with primary hyperparathyroidism (PHPT) to qualify for minimally invasive parathyroidectomy [ 1 , 2 ]. Unfortunately, up to 20% of imaging results are inconclusive [ 3 ]. Neck ultrasonography and 99m Tc-MIBI scintigraphy (MIBI) are first-line imaging techniques widely used for PA localization [ 4 ].…”

Tumoral calcinosis of the left shoulder joint periarticular soft tissue secondary to end-stage renal disease

“…Neck ultrasound and 99mTcMIBI scintigraphy should be performed in HPT. Complex cases may require further diagnostics (CT, MRI, ¹⁸F-FCH PET/CT, biopsy) to exclude other pathologies [2][3][4][5].…”