“…The cervix is tightly closed during the follicular and luteal phases of the menstrual cycle and relaxes shortly before menstruation. 70,71 Despite these similarities, there are also many differences between menstruation and parturition, the most apparent of which are the site of progesterone production, absolute progesterone levels, the size of the uterus, and impact of uterine stretch. In addition to the tissues of the placenta proper, the fetal membranes appear to have a distinct and separate role in parturition, expressed via a decline in mechanical capacity, programmed senescence, and through their effect on glucocorticoid, surfactant, chemokine, and PG production and signaling.…”