The usefulness of soluble transferrin receptor (sTfR) in differentiating anemia occurring in young children

Kamer, Barbara; Dółka, Elżbieta; Pasowska, Renata; Świątkowska, Ewa

doi:10.5603/19760

Cited by 5 publications

(6 citation statements)

References 40 publications

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“…sTfR values >1.55 mg/L, and sTfR Index values >1.03mg/L were predictive of iron deficiency anemia in the presence or absence of inflammation and chronic disease. Kamar et al 18 study showed following result which is similar to our study.…”

Section: Resultssupporting

confidence: 92%

Utility of sTFR/Ferritin index to differentiate iron deficiency anaemia and anaemia of chronic disease

H¹,

Nipanal²,

Ashok³

2021

IJNMHS

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Background: Iron deficiency is a common condition that is usually diagnosed using conventional laboratory tests of iron status, such as serum ferritin and transferrin saturation. However, both ferritin and transferrin proteins are markedly influenced by inflammation, behaving as acute-phase reactants and making it difficult to differentiate between iron-deficiency anemia (IDA) and anemia of chronic disease (ACD). Objectives: To assess the utility of sTfR/ Log ferritin Index to differentiate Iron deficiency anaemia and Anaemia of chronic disease. Materials and Methods: A cross-sectional study was conducted in the Department of Medicine, Victoria hospital and Bowring and Lady Curzon hospital, Bangalore Medical College and Research institute, Bangalore. A total of 150 blood samples were evaluated, i.e., 50 samples from iron deficiency anaemia group and 50 samples from patients with anaemia of chronic disorders & 50 samples from healthy normal individual.Results: In present study, samples are age matched with mean age of control 45.66±10.23, ACD 50.68±18.03, IDA 48.14±18.47. Hb, MCV, MCHC & MCH were decreased in both the groups. However, the decrease in Hb & MCV was much more in IDA as compared to ACD. Microcytosis was seen in 92% cases of IDA while it was observed in only 11% cases of ACD. sTfR/ log ferritin index was >1.5 in 80% of IDA. 90% of ACD and control subjects had sTfR/log ferritin index <1.5. sTfR levels were significantly higher in IDA (7.7± 5.8) as compared to the ACD cases (1.6 ±0.89) (p<0.001). sTfR/Log ferritin index is significantly higher in patients with Iron deficiency anemia (9.34±10.25) as compared to ACD (0.76±0.52) (p<0.001). Conclusion: sTFR/Log ferritin index indices is very useful in differentiating pure IDA, ACD and ACD with coexisting iron deficiency, thus providing a non-invasive alternative to bone marrow iron.

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Section: Resultssupporting

confidence: 92%

Utility of sTFR/Ferritin index to differentiate iron deficiency anaemia and anaemia of chronic disease

H¹,

Nipanal²,

Ashok³

2021

IJNMHS

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“…A correlation analysis showed statistically significant relationships between both sTfR and the sTfR/log ferritin and TIBc and Serum ferritin in IDA children. No such relationship was found in other groups, in accordance to the results of Kamer et al [8]. Other authors did not show any statistical significant correlations between sTfR and biochemical iron indice [21].…”

Section: Discussionsupporting

confidence: 83%

“…Soluble transferrin receptor (sTfR) is a truncated extracellular form of the membrane transferrin receptor produced by proteolysis [7]. The parameter defined as TfR-F index is calculated in terms of sTfR/log ferritin and sTfR are good indicators of iron deficiency and could be useful in the differential diagnostics of anemia [8].…”

Section: Introductionmentioning

confidence: 99%

Value of Soluble Transferrin Receptors and sTfR/log Ferritin in the Diagnosis of Iron Deficiency Accompanied by Acute Infection

El-Gendy

El-Hawy

Rizk

et al. 2017

Indian J Hematol Blood Transfus

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There are many causes of anemia; the most common of these are acute and chronic infections, iron deficiency, or both. Identifying the cause is a very important step in management of anemia. So, we evaluated the usefulness of soluble transferrin receptor (sTfR) and of the sTfR/log ferritin in the diagnosis of iron deficiency anemia accompanied by acute infection. This study was conducted on 131 children aged 2-11 years old from those who attended the pediatric outpatient clinics in Menoufia university hospital. Hematological indices, iron balance and sTfR were evaluated and the sTfR/log F was calculated for each examined child. From the examined children four groups were distinguished (control): included 34 healthy children with normal iron status (66.7% males, age 4.2 ± 1.2). (IDA): included 38 children diagnosed as iron deficiency anemia (47.4% males, age 4.9 ± 1.6). (IDA + infection): included 26 children with infectious disease (upper respiratory tract infection, otitis media, pneumonia, stomatitis, and urinary tract infection) and anemia meeting criteria of IDA (50% males, age 4.2 ± 0.7). (anemia + infection): included 33 children with infectious anemia without iron deficiency (56.2% males, age 5.06 ± 1.4). It was proved that sTfR and sTfR/log Ferritin were significantly higher in children with anemia due to iron deficiency, and in those with infection + iron deficiency, versus those with infectious anemia or in healthy children. The use of sTfR and sTfR/log ferritin improves the diagnosis of IDA in pediatric patients, especially in the presence of coexisting acute infection.

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“…Transferrin saturation index (TSI) was calculated by the following formula: iron concentration divided by TIBC and multiplied by 100. The TSI > 16% values were regarded as correct ones 25. Serum ferritin levels were measured to assess the iron status of our patients by Enzyme Linked Immune Sorbent Assay (ELISA) technique using (RAMCO LABORATORIES kit, INC., USA), and HCV antibodies were detected by ELISA using (AUTOBIO DIAGNOSTICS, China) kit on microplate reader (Bio-Rad 680 Hercules, California, USA).…”

Section: Methodsmentioning

confidence: 99%

Assessment of obesity and hepatic late adverse effects in the Egyptian survivors of pediatric acute lymphoblastic leukemia: single center study

El-Rashedy¹,

El-Hawy²,

Hefnawy³

et al. 2017

Mediterr J Hematol Infect Dis

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BackgroundChildhood acute lymphoblastic leukemia (ALL) with current cure rates reaching 80% emphasizes the necessity to determine treatment-related long-term effects. The aim of this study is to estimate the prevalence of overweight, obesity, and hepatic late adverse effects in a cohort of ALL survivors treated at the Hematology and Oncology Unit, Pediatrics Department, Menoufia University, Egypt.MethodsIn this case-control study, height, weight, and body mass index (BMI) were assessed for 35 pediatric ALL survivors and 35 healthy children. These parameters were plotted on the growth and WHO standard deviation charts for both males and females. Overweight and obesity were defined by BMI > 85th and 95th percentile respectively. Laboratory investigations were done in the form of iron profile, liver enzymes, total and direct bilirubin levels, serum urea &creatinine and detection of hepatitis C virus antibodies by ELISA.ResultsThe weight and BMI were significantly greater in the survivors than controls (P value =0.002 and 0.039 respectively). ALT, total & direct bilirubin, serum ferritin and transferrin saturation were considerably higher in the survivors than the controls (P value = 0.03, 0.036, 0.044, 0.006 and 0.03 respectively). Ten (28.6%) of survivors had hepatitis C antibodies with none (0%) of controls (P value =0.02)ConclusionsPediatric ALL survivors are at increased risk of overweight/obesity, hepatic dysfunction in the form of elevated liver enzymes, bilirubin levels, and C viral hepatitis. Screening of those survivors for such complications should be considered.

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The usefulness of soluble transferrin receptor (sTfR) in differentiating anemia occurring in young children

Cited by 5 publications

References 40 publications

Utility of sTFR/Ferritin index to differentiate iron deficiency anaemia and anaemia of chronic disease

Utility of sTFR/Ferritin index to differentiate iron deficiency anaemia and anaemia of chronic disease

Value of Soluble Transferrin Receptors and sTfR/log Ferritin in the Diagnosis of Iron Deficiency Accompanied by Acute Infection

Assessment of obesity and hepatic late adverse effects in the Egyptian survivors of pediatric acute lymphoblastic leukemia: single center study

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