The usefulness of routinely used malnutrition screening tools in predicting anemia in lung cancer patients

Zabłocka‐Słowińska, Katarzyna; Kosacka, Monika; Porębska, Irena; Pawełczyk, Konrad; Gołecki, Marcin; Biernat, Jadwiga; Grajeta, Halina

doi:10.17219/acem/65785

Cited by 7 publications

(5 citation statements)

References 32 publications

(44 reference statements)

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“…Anemia is a common hematological manifestation of cancer (1,2,18). Anemia is considered a side effect associated with chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…About 38% of lung cancer patients have anemia. Cancer-related anemia results from various conditions such as malnutrition, disease progression, renal or bone marrow involvement, coexisting inflammation, and oncologic treatment including chemotherapy and radiotherapy (1,2). Cancer cells can produce inflammatory cytokine such as interleukin-6 (IL-6) that can directly and indirectly lead to anemia by inhibiting erythropoiesis (3).…”

Section: Introductionmentioning

confidence: 99%

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Clinical significance of anemia as a prognostic factor in non-small cell lung cancer carcinoma with activating epidermal growth factor receptor mutations

et al. 2020

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Background: Anemia is a frequent finding in cancer patients. Pre-treatment anemia is known to be associated with poor survival after surgery or stereotactic body radiation therapy of non-small cell lung cancer (NSCLC). However, little study was conducted in NSCLC with activating epidermal growth factor receptor (EGFR) mutations. Methods: This was a multicenter retrospective study conducted in seven university teaching hospitals in the Republic of Korea from January 2009 to February 2016. A total of 290 patients were diagnosed with NSCLC harboring sensitizing EGFR mutations and treated with EGFR-tyrosine kinase inhibitor (TKI) as 1st line. Of these patients, 104 met the exclusion criteria. Pre-treatment anemia was defined according to World Health Organization criteria (Hb concentration <13 g/dL for men and <12 g/dL for women). Results: A total of 186 patients were finally included for analysis. Of these patients, 86 (46.2%) and 100 (53.8%) patients were classified into anemia and non-anemia groups, respectively. The anemia group had shorter median overall survival (OS) than the non-anemia group [24.83 (95% CI,) months, P=0.031]. In multivariate analysis, anemia (aHR, 2.573; 95% CI, 1.122-5.901; P=0.026) was only independent factors for poor OS.Conclusions: Our study suggests that pre-treatment anemia is a significant poor prognostic factor for OS of NSCLC patients with EGFR mutations treated with EGFR-TKI.

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“…Anemia is a common hematological manifestation of cancer (1,2,18). Anemia is considered a side effect associated with chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical significance of anemia as a prognostic factor in non-small cell lung cancer carcinoma with activating epidermal growth factor receptor mutations

et al. 2020

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“…Seventy percentage of this cohort had advanced NSCLC. In the same study the MNA also predicted the likelihood of anaemia in patients with lung cancer [31]. The presence of malnutrition in lung cancer has been shown to affect QoL.…”

Section: Key Pointsmentioning

confidence: 72%

Dietetic assessment and intervention in lung cancer

Phillips

Hug

Allan

et al. 2019

Current Opinion in Supportive &Amp; Palliative Care

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Purpose of reviewSystemic therapy for lung cancer is increasing in intensity and duration. European nutrition guidelines suggest screening for weight loss and malnutrition, however acknowledges there is a lack of evidence. We discuss current data round this issue and identify opportunities for further research. Recent findingsInternational guidelines now exist to aid the definition of weight loss in cancer, including cachexia, sarcopenia and malnutrition. These allow consistent definition of overlapping, but distinct clinical syndromes. Nutritional status can be assessed in a range of ways including questionnaires, functional assessments, blood markers, physical activity, weight and BMI. Weight loss is commonly associated with a proinflammatory state. Future treatment is likely to be a combination of dietetic support and pharmacological treatment of cachexia. SummaryThere is a paucity of data on dietetic intervention. It is potentially quick, inexpensive and patient specific, using a holistic approach to aid patients who are malnourished or at risk of malnutrition. Lung cancerrelated weight loss is common, further strategies are needed to effectively assess and intervene. Dietetic intervention has the potential to improve patients' quality of life and outcomes.

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“…Even though anaemia was not found to be fitted with inclusion criteria because it contains 50% of missing values, the main reason for including it in the analysis is that many papers discussed the relationship between the disease progression, the oncology treatments including radiotherapy, chemotherapy [ 36 , 37 ], ageing and advanced stage [ 38 ], on one side, and the toxicity manifested in the patient, that in terms of statistical significance is considered to be a bad prognostic factor [ 39 ], and in terms of clinical significance, those attended to have different grades of anaemia, especially the fourth one, are more likely to never attend the OS threshold in terms of quality of life thus clinical response and therefore have a poor survival probability.…”

Section: Discussionmentioning

confidence: 99%

Lung cancer in middle and southern Morocco

Tafenzi¹,

Choulli²,

Baladi³

et al. 2023

ecancer

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Purpose Determining risk factors associated with a fatal disease such as lung cancer (LC) remains an important key to understanding the factors related to its development and therefore using the correct emergent or accessible treatments. For that, we sought to highlight by describing, and analysing, the risk factors related to LC survival, reflecting the actual situation in Morocco. Patients and methods We included 987 LC patients diagnosed from 2015 to 2021 at the Medical Oncology Department at the Mohammed VI University Hospital of Marrakech. An overview of the LC situation was described, and analysed, to determine the risk factors related to survival. The independent prognostic factors were determined using Cox Proportional Hazards Regression Analysis. To create a distinction between different risks group in the survival curve, stratification was done, respectively, within sex, age, histology type, treatments and radiation therapy. Results We finally included 862 patients with 15 parameters among the 27 extracted, all meeting the inclusion criteria. 89.1% of the patients were male ( n = 768) and 10.9% were female ( n = 94), of whom 83.5% had a history of tobacco smoking ( n = 720). The median survival of both sexes was 716 (5–2,167) days. The average age at diagnosis was 60 years. Five hundred and thirty-four patients presented with advanced stage. Patients above 66 years were the more diagnosed category with adenocarcinoma at T4N2M1c pathological category, and endocrinal comorbidity, in addition to pleurisy syndrome. Moreover, family history was found to be a bad prognostic factor. Interestingly, smoking status was not a bad contributor to survival. Age at diagnosis, histology subtype, performance status, haemoglobin, numbers of cures of the first-line chemotherapy, radiotherapy, anaemia and treatments were identified as risk factors related to survival. Conclusion We established a descriptive and analytical overview of the current LC epidemiology situation in the oncology division of Mohammed VI University Hospital in a non-industrialised state taking into account smoking status.

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The usefulness of routinely used malnutrition screening tools in predicting anemia in lung cancer patients

Abstract: Background. Anemia and malnutrition are frequently observed during lung cancer development, and the associations between them have been researched. However, no study concerning the utility of routinely used nutritional screening tools in predicting anemia in lung cancer has been performed.

Cited by 7 publications

References 32 publications

Clinical significance of anemia as a prognostic factor in non-small cell lung cancer carcinoma with activating epidermal growth factor receptor mutations

Clinical significance of anemia as a prognostic factor in non-small cell lung cancer carcinoma with activating epidermal growth factor receptor mutations

Dietetic assessment and intervention in lung cancer

Lung cancer in middle and southern Morocco

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