The usefulness of nimodipine, an L-calcium channel antagonist, in the treatment of tinnitus

Davies, Ewart; Knox, Ellen; Donaldson, Ivor

doi:10.3109/03005369409086559

Cited by 42 publications

(25 citation statements)

References 6 publications

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“…Other drugs already studied for treatment of tinnitus are lidocaine,[12] antidepressants,[13] baclofen,[14] caroverine,[15] nimodipine,[16] clonazepam[17] and trimetazidine. [18] The introduction of these drug therapies have increased the success of tinnitus treatment.…”

Section: Discussionmentioning

confidence: 99%

Role of acamprosate in sensorineural tinnitus

et al. 2012

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Acamprosate with dual mechanism of action as glutamate antagonist and GABA agonist can be a potential target to decrease the severity of sensorineural tinnitus.Objective:(1)To study the effectiveness of acamprosate in providing subjective relief and objective improvement in patients having tinnitus of sensorineural origin. (2) To evaluate the adverse events related to the use of acamprosate and also determine the change in quality of life (QOL) parameters.Materials and Methods:The study was randomized double-blind, placebo controlled, crossover. Forty adult subjects (>18 years of age), of either sex with tinnitus of sensorineural origin, were administered either acamprosate 333 mg TDS or matched placebo for a period of six weeks followed by a washout period of one week. Drug therapy was switched for another six weeks in consonance with the crossover design. The effect of acamprosate and placebo on subjective relief and objective improvement was evaluated by using modified tinnitus severity, QOL scores and audiometry with tinnitus matching in frequency and loudness.Results:At the end of the study, the drug had shown a statistically significant improvement in reducing the tinnitus score in 92.5% of the patients and placebo with an improvement in 12.5% of the patients. The drug was well tolerated without any serious drug reactions.Conclusion:Acamprosate is an effective drug in treating the severity of sensorineural tinnitus without causing much of the side effects.

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Section: Discussionmentioning

confidence: 99%

Role of acamprosate in sensorineural tinnitus

et al. 2012

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“…Diuretics, 79 anticoagulants, 80 and vasodilators 81 have been tried without success. The drug betahistine, licensed in Europe but not the USA, is thought to help Ménière's disease by improving cochlear blood fl ow.…”

Section: Drug Treatmentsmentioning

confidence: 99%

Tinnitus

Baguley¹,

McFerran²,

Hall³

2013

The Lancet

1,027

911

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Tinnitus is a common medical symptom that can be debilitating. Risk factors include hearing loss, ototoxic medication, head injury, and depression. At presentation, the possibilities of otological disease, anxiety, and depression should be considered. No eff ective drug treatments are available, although much research is underway into mechanisms and possible treatments. Surgical intervention for any otological pathology associated with tinnitus might be eff ective for that condition, but the tinnitus can persist. Available treatments include hearing aids when hearing loss is identifi ed (even mild or unilateral), wide-band sound therapy, and counselling. Cognitive behavioural therapy (CBT) is indicated for some patients, but availability of tinnitus-specifi c CBT in the UK is poor. The evidence base is strongest for a combination of sound therapy and CBT-based counselling, although clinical trials are constrained by the heterogeneity of patients with tinnitus.

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“…This has been primarily because of the complexity of the central nervous system, and the multifactorial causes of tinnitus. 14 Other drugs already studied for treatment of tinnitus are baclofen (improvement in about 9.7%), 15 caroverine (63.3%), 16 nimodipine (16.13%), 17 clonazepam (32%) 18 and trimetazidine (89%). 19 Different studies have shown that sensorineural tinnitus is caused by an imbalance of two neurotransmitters Glutamate and GABA in the auditory pathway.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of Acamprosate With Other Drugs in Central Tinnitus

Kaur¹,

Jyoti²

2013

jemds

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AIM:To compare the efficacy of acamprosate with other drugs to decrease the severity of sensorineural tinnitus. MATERIAL AND METHOD: The study was randomised double-blind, placebo controlled, crossover. Forty adult subjects (>18 years of age), of either sex with tinnitus of sensorineural origin, were administered either acamprosate 333 mg tds or matched placebo for a period of six weeks followed by a washout period of one week. Drug therapy was switched for another six weeks in consonance with the crossover design. The effect of acamprosate and placebo on subjective relief and objective improvement was evaluated by using modified tinnitus severity quality of life scores and audiometry with tinnitus matching in frequency and loudness. RESULTS: At the end of study the drug had shown a statistically significant improvement in reducing the tinnitus score in 92.5% of the patients and placebo with an improvement in 12.5% of the patients in contrast to other drugs belonging to this group. CONCLUSION: Acamprosate is an effective drug in treating the severity of sensorineural tinnitus

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The usefulness of nimodipine, an L-calcium channel antagonist, in the treatment of tinnitus

Cited by 42 publications

References 6 publications

Role of acamprosate in sensorineural tinnitus

Role of acamprosate in sensorineural tinnitus

Tinnitus

Comparative Evaluation of Acamprosate With Other Drugs in Central Tinnitus

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