The usefulness of fecal calprotectin in assessing inflammatory bowel disease activity

Lee, Yang Woon; Lee, Kang-Moon; Lee, Ji Min; Chung, Yoon Yung; Kim, Dae Bum; Kim, Yeon Ji; Chung, Woo Chul; Paik, Chang Nyol

doi:10.3904/kjim.2016.324

Cited by 31 publications

(31 citation statements)

References 29 publications

(33 reference statements)

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“…Many physicians treating IBD still adopt a clinically-based management[ 56 ], even if recent data suggest that many IBD patients in clinical remission still have subclinical mucosal inflammation[ 57 ]. FC is correlated with clinical activity evaluated either by Sutherland criteria[ 58 ] or Partial Mayo Score[ 59 ]. In a study by Xiang et al[ 58 ], FC concentrations were useful to discriminate patients with active UC, inactive UC and control, with a cut-off point of 50 μg/g showing 91.9% sensitivity and 79.4% specificity; in patients with UC, FC had a better correlation with clinical activity than CRP.…”

Section: Fc In Ibdmentioning

confidence: 99%

“…Schoepfer and colleagues[ 63 , 64 ] found that FC was the only marker able to discriminate among mild, moderate and severe disease. A recent Korean study[ 59 ] highlighted how not only the ELISA, but also the Quantitative POCT predicted endoscopic inflammation (Mayo endoscopic score ≥ 1) in UC at a cut-off value of 201.3 μg/g and 150.5 μg/g respectively. In CD, a significant correlation with endoscopic activity was found both in colonic[ 33 ] and in small bowel CD[ 36 ], as well as with capsule endoscopy[ 65 ].…”

Section: Fc In Ibdmentioning

confidence: 99%

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From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting

Mumolo

Bertani

Ceccarelli

et al. 2018

WJG

133

116

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Fecal calprotectin (FC) has emerged as one of the most useful tools for clinical management of inflammatory bowel diseases (IBD). Many different methods of assessment have been developed and different cut-offs have been suggested for different clinical settings. We carried out a comprehensive literature review of the most relevant FC-related topics: the role of FC in discriminating between IBD and irritable bowel syndrome (IBS) and its use in managing IBD patients In patients with intestinal symptoms, due to the high negative predictive value a normal FC level reliably rules out active IBD. In IBD patients a correlation with both mucosal healing and histology was found, and there is increasing evidence that FC assessment can be helpful in monitoring disease activity and response to therapy as well as in predicting relapse, post-operative recurrence or pouchitis. Recently, its use in the context of a treat-to-target approach led to a better outcome than clinically-based therapy adjustment in patients with early Crohn’s disease. In conclusion, FC measurement represents a cheap, safe and reliable test, easy to perform and with a good reproducibility. The main concerns are still related to the choice of the optimal cut-off, both for differentiating IBD from IBS, and for the management of IBD patients.

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Section: Fc In Ibdmentioning

confidence: 99%

Section: Fc In Ibdmentioning

confidence: 99%

From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting

Mumolo

Bertani

Ceccarelli

et al. 2018

WJG

133

116

View full text Add to dashboard Cite

show abstract

“…Unlike the FC concentration, which showed a significant difference between the age groups, no sig-Most of the reported articles had been about IBD patients, infant diarrhea, and meta-analysis results of the IBD patient group[17] as well as review articles[18][19][20]. Studies on FC are Thus, we conducted this study on healthy male and female adults residing in Jeju, between the age of 30 and 90, to understand the normal range of FC concentration.Another notable finding in the present study's results is that FC showed a statistically significant difference between males and females.…”

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confidence: 99%

Age-Related Fecal Calprotectin Concentrations in Healthy Adults

박신영

2020

Korean J Clin Lab Sci.

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Fecal calprotectin (FC) is a marker used for the differential diagnosis of inflammatory bowel disease (IBD). FC is also used to determine the effects of treatment and recurrence prediction because of its non-decomposition by bacteria, relative week stability at room temperature, and its uniform distribution within feces. Healthy male and female adults between the age of 30 and 80 living in Jeju were selected for this study. The FC concentration in the healthy control group (N=45) was distributed widely as 0∼545.9 μg/g and showed a significant difference with age in healthy adults. The FC concentration in adults over 70 years old (80.6 years on average) was 160.3 μg/g. The result is approximately 10 times higher than in adults below 50 years (44 years on average), with FC concentrations at 15.88 μg/g. Moreover, adults over 50 years, with an average age of 59.6, had FC concentrations of 35.46 μg/g, which were two times higher than the below 50-year-old group, confirming the significant correlation between age and FC concentration. As the FC test is a non-invasive and cost-effective objective marker in IBD tests, a suitable cutoff value is required for different ages. This study provides the baseline data for differential diagnoses.

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“…As a result, fecal calprotectin is an indicator of in ammation in the gastrointestinal tract [17,18]. Calprotectin lasts for a week in the stool which makes it a good marker for detecting in ammation in the gut [17,19]. However, other studies with different results have been reported.…”

Section: Resultsmentioning

confidence: 99%

Fecal Calprotectin in patients with Infantile Colic: A case-control study

Khoshnevisasl

Sadeghzadeh

Mahmoudirad

et al. 2020

Preprint

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Back groundThe precise etiology of infantile colic has not been elucidated after many years of research. In this study, we aimed to determine the association of fecal calprotectin with infantile colic.MethodThis case control study was performed on colicky infants referred to pediatrics clinics in Zanjan over a 6-month period. Infantile colic was clinically defined based on wessel criteria. The control group consisted of healthy infants matched for age, sex, weight, and type of feeding with the case group. Fecal calprotectin levels were measured in both groups by the ELISA method.ResultsForty infants were divided equally into case and control groups. The cases consisted of 11 boys (55%) and 9 girls (45%) with a mean age of 63 days and in the control group there was 12 boys (60%) and 8 girls (40%) with mean age of 48 days. Fecal calprotectin was positive in 17 (85%) cases and 6 (30%) controls. This difference was statistically significant. There was no significant difference in fecal calprotectin regarding sex, age, weight and type of nutrition in both colicky infants and controlsConclusionFecal calprotectin levels in colicky infants were significantly higher than healthy infants.

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The usefulness of fecal calprotectin in assessing inflammatory bowel disease activity

Abstract: FC was strongly associated with disease activity indices, serologic markers, and endoscopic activity in patients with IBD. QPOCT can be used more conveniently than ELISA to assess FC in clinical practice.

Cited by 31 publications

References 29 publications

From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting

From bench to bedside: Fecal calprotectin in inflammatory bowel diseases clinical setting

Age-Related Fecal Calprotectin Concentrations in Healthy Adults

Fecal Calprotectin in patients with Infantile Colic: A case-control study

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