The usefulness of diffusion-weighted magnetic resonance imaging in bladder cancer staging and functional analysis

Yumura, Yasushi; Kobayashi, Shigeki; Isoshima, Shiho; Arima, Kiminobu; Sakuma, Hajime; Sugimura, Yoshiki

doi:10.4103/0973-1482.138225

Cited by 28 publications

(21 citation statements)

References 15 publications

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“…It can also help improve the determination of tumor extent. Authors of many studies have investigated the accuracy of MR imaging in local staging (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21). These studies differ in their use of magnetic field strengths, combinations of anatomic and functional MR imaging techniques, and number of patients.…”

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confidence: 99%

The Diagnostic Value of MR Imaging in Differentiating T Staging of Bladder Cancer: A Meta-Analysis

et al. 2018

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Purpose To assess the diagnostic accuracy of magnetic resonance (MR) imaging for differentiating stage T1 or lower tumors from stage T2 or higher tumors and to analyze the influence of different imaging protocols in patients with bladder cancer. Materials and Methods A systematic literature search for original diagnostic studies was performed in PubMed, Medline, the Cochrane Library, and Web of Science. The methodologic quality of each study was evaluated by two independent reviewers who used the Quality Assessment of Diagnostic Accuracy Studies 2 tool. Data necessary to complete 2 × 2 tables were obtained, and patient, study, and imaging characteristics were extracted. Statistical analysis included data pooling, heterogeneity testing, sensitivity analyses, and forest plot construction. Results Seventeen studies (1449 patients with bladder cancer) could be analyzed. The pooled sensitivity and specificity of MR imaging were 0.90 (95% confidence interval [CI]: 0.83, 0.94) and 0.88 (95% CI: 0.77, 0.94), respectively, for differentiating tumors staged T1 or lower from those staged T2 or higher. Diffusion-weighted imaging and use of higher field strengths (3 T) improved sensitivity (0.92; 95% CI: 0.86, 0.96) and specificity (0.96; 95% CI: 0.93, 0.98). Conclusion This meta-analysis demonstrated high diagnostic performance of MR imaging for differentiating T1 or lower tumors from T2 or higher tumors in patients with bladder cancer. Higher field strength (3 T) and the use of diffusion-weighted imaging can slightly help improve sensitivity and specificity. RSNA, 2017.

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confidence: 99%

The Diagnostic Value of MR Imaging in Differentiating T Staging of Bladder Cancer: A Meta-Analysis

et al. 2018

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“…23 Recent advances in MRC include multiparametric and combined imaging modalities to assess colon-related diseases. For instance, a multiparametric approach (dynamic contrast-enhanced and diffusion-weighted imaging [DWI]) has been used to help diagnose rectal cancer, [10][11][12][13][14]26 and combined MRI positron emission tomography has been used to assist with tumor grading and staging. 13,27 In a recent novel approach, MRC and a perfluorinated liquid (Fluorinert) were used in a mouse model of colon cancer to clearly delineate the inflamed colonic wall and visualize luminal tumors at various stages of development.…”

Section: Discussionmentioning

confidence: 99%

“…The developed method allowed the visualization of the leakage of the MRI contrast agent through the bladder urothelium into the peritoneal space in the bladder dome region [9]. Clinically, the use of MRI to assess the bladder is mainly restricted to the detection of bladder carcinomas [10–14], with only a few applications to assess bladder wall physiology [15] and morphology [16,17]. …”

Section: Introductionmentioning

confidence: 99%

“…9 The developed method allowed the visualization of the leakage of the MRI contrast agent through the bladder urothelium into the peritoneal space in the bladder dome region. 9 Clinically, the use of MRI to assess the bladder is mainly restricted to the detection of bladder carcinomas, [10][11][12][13][14] with only a few applications to assess bladder wall physiology 15 and morphology. 16,17 In our report we also used CE-MRI to assess bladdercolon crosstalk by monitoring a CE-MRI signal intensity (SI) increase in colon regions following exposure of the bladder to PS.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of colon and bladder crosstalk in an experimental colitis model using contrast‐enhanced magnetic resonance imaging

Towner

Smith

Saunders

et al. 2015

Neurogastroenterology Motil

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Background Inflammatory bowel disease (IBD) consists of two chronic remitting-relapsing inflammatory disorders in the colon referred to as ulcerative colitis (UC) and Crohn’s disease (CD). IBD affects about 1.4 million Americans. TNBS (2,4,6-trinitrobenzene sulfonic acid)-induced colitis is a widely used model of experimental intestinal inflammation with characteristic transmural and segmental lesions that are similar to CD. Methods Here we report on the use of contrast-enhanced MRI (CE-MRI) to monitor in vivo bladder permeability changes resulting from bladder crosstalk following colon TNBS exposure, and TNBS-induced colitis. Changes in MRI signal intensities and histology were evaluated for both colon and bladder regions. Key Results Uptake of contrast agent in the colon demonstrated a significant increase in signal intensity (SI) for TNBS-exposed rats (p<0.01) compared to controls. Additionally, a significant increase in bladder SI for colon TNBS-exposed rats (p<0.001) was observed compared to saline controls. Histological damage within the colon was observed, however bladder histology indicated a normal urothelium in rats with TNBS-induced colitis, despite increased permeability seen by CE-MRI. Conclusions & Inferences CE-MRI was able to quantitatively measure inflammation associated with TNBS-induced colitis, as well as assess bladder crosstalk measured as an increase in urothelial permeability. Although CE-MRI is routinely used to assess inflammation with IBD, currently there is no diagnostic test to assess bladder crosstalk with this disease, and our developed method may be useful in providing crosstalk information between organ and tissue systems in IBD patients, in addition to colitis.

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“…Consequently, malignant tumours exhibit high signal intensity by DW-MRI, attributed to their higher cellularity, increased extracellular tortuosity and tissue disorganization resulting in restricted water diffusion [35]. Yamada et al r e p o r t e d t h a t t h e a d d i t i o n diffusion-weighting to conventional MRI may not only improve the accuracy of detection BC, but also may aid in the prognosis of BC [36]. Another finding of our study was that DW-MRI can differentiate MIBC form NMIBC.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity and Specificity of Diffusion-Weighted Magnetic Resonance Imaging in Diagnosis of Bladder Cancers

Zhai¹,

Wang²,

Zhu³

et al. 2015

CIM

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Purpose: Our study is designed to examine the diagnostic performance of diffusion-weighted magnetic resonance imaging (DW-MRI) for bladder cancers (BC), and to determine whether DW-MRI can differentiate muscle invasive bladder cancer (MIBC) from non-MIBC (NMIBC).Methods: A meta-analysis was performed of published studies that investigated the performance of DW-MRI for BC. These studies were retrieved from scientific literature databases using sensitive electronic search strategies. The STATA 12.0 and Meta-disc software were employed for statistical analyses of data extracted from selected studies.Results: Our search initially returned 230 articles, of which 11 met the inclusion criteria and were enrolled into the final meta-analysis. Five of the included studies reported the diagnostic performance of DW-MRI for BC with a cumulative total of 243 BC patients and 82 healthy subjects. Eight studies investigated the diagnostic performance of DW-MRI for differentiating MIBC from NMIBC, involving 259 MIBC lesions and 515 NMIBC lesions. Meta-analysis results were as follows: the diagnostic performance of DW-MRI for Conclusion: DW-MRI has an outstanding diagnostic performance, with advanced sensitivity and specificity, for imaging of bladder cancers and for differentiating MIBC from NMIBC.

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The usefulness of diffusion-weighted magnetic resonance imaging in bladder cancer staging and functional analysis

Abstract: We demonstrated that DW-MRI is not only useful for bladder cancer T staging, but also a prognostic factor for patients with bladder cancer.

Cited by 28 publications

References 15 publications

The Diagnostic Value of MR Imaging in Differentiating T Staging of Bladder Cancer: A Meta-Analysis

The Diagnostic Value of MR Imaging in Differentiating T Staging of Bladder Cancer: A Meta-Analysis

Assessment of colon and bladder crosstalk in an experimental colitis model using contrast‐enhanced magnetic resonance imaging

Sensitivity and Specificity of Diffusion-Weighted Magnetic Resonance Imaging in Diagnosis of Bladder Cancers

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