The Usefulness of Common IVY (Hedera helix L.) Extracts Against Bacterial and Fungal Pathogens Found in Local Hospitals

Abstract

The current study was carried out to highlights the antibacterial and antifungal activity of Hedera helix L. by using its different fractions. Both activities were carried out under agar well diffusion method, while for fractions obtaining the cold maceration method was followed which were tested against four fungal species including Fusarium oxysporum, Aspergillus flavors, P. pallidum and Alternaria alternate and four bacterial strains, Staphylococcus aureus, Streptococcus mutans, Serratia marcescens and Methicillin resistance, Staphylococcus aureus. The fractions which were extracted from the Hedera helix shown different zone of inhibition (ZOI) against both the fungal and bacterial strains. Chloroform and n-hexane extracted samples showed the highest antifungal activity against Polyspondylium pallidum with complete inhibition zone and the least activity was shown by an aqueous fraction. In the antibacterial activity, the crude methanolic extracts have shown the highest inhibition zone (46-57%) against the selected bacterial strains, while the lowest activity was reported from aqueous fractions (21-26%). The other fractions moderately inhibit the growth of the selected strains but were significant.

Localisation of active substances in Hedera helix leaves and Linaria vulgaris shoots used in pharmaceutical and cosmetic industry

“…Leaves of its creeping shoots have been used as a pharmaceutical and cosmetic raw material since ancient Greece [Bezruk et al 2020a]. Raw Hederae Folium is extremely rich in triterpene saponins, flavonoids, phenolic acids, polyacetylenes, essential oil, sterols, sesquiterpenes, and coumarins [Lutsenko et al 2010, Bezruk et al 2020b, Rehman et al 2022, Shokry et al 2022] and contains some amounts of emetine alkaloids [Alkattan et al 2021].…”