The Usefulness of CD26 in Flow Cytometric Analysis of Peripheral Blood in Sézary Syndrome

Kelemen, Katalin; Guitart, Joan; Kuzel, Timothy M.; Goolsby, Charles L.; Peterson, Lo Ann C.

doi:10.1309/05gfg3ly3vycdmey

Cited by 64 publications

(52 citation statements)

References 2 publications

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“…We concur with the conclusions of the authors of several previous studies, that alterations in CD26 expression are most significant when combined with aberrant expression levels of other T-cell antigens (3,4,(15)(16)(17).…”

Section: Cd26 Expression In T Cells In Tissues and Body Fluidssupporting

confidence: 92%

“…In the majority of cases of cutaneous T-cell lymphomas (CTCL) involving the peripheral blood (i.e. mycosis fungoides and Sezary syndrome [MF/ SS]), the neoplastic cells are CD41 and negative for CD26 (2)(3)(4). Several publications have emphasized quantitation of the CD41CD262 subset of T cells in the peripheral blood in the diagnosis and followup of MF/SS (2,5,6).…”

mentioning

confidence: 99%

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Utility of CD26 in flow cytometric immunophenotyping of T‐cell lymphomas in tissue and body fluid specimens

Pierson

Jones

Muzzafar³

et al. 2008

Cytometry Part B Clinical

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Background: CD26 is expressed by most CD41 T cells in normal peripheral blood specimens. Neoplastic T cells are frequently CD262 in mycosis fungoides/Sezary syndrome involving the peripheral blood. However, CD26 expression by reactive and neoplastic T cells in solid tissues and body fluids has not been fully characterized by flow cytometry (FC).Methods: Solid tissue and body fluid specimens were assayed for CD26 expression using four-color FC immunophenotyping, by qualitative assessment of population clusters, and by quantitation with comparison with isotype controls. Benign T cells were studied in reactive tissues and in the background of other malignancies.Results: Many T-cell lymphomas were dim or negative for CD26, whereas a few were brightly positive. In the majority of T-cell lymphomas, CD26 expression could potentially help identify aberrant population clusters. T cells in reactive tissue specimens and tumor-infiltrating T cells were commonly dim to negative for CD26.Conclusions: Both T-cell lymphomas and reactive T cells in tissue and body fluid specimens often show low levels of CD26 expression. Therefore, quantitative methods may not reliably distinguish benign from neoplastic T cells in these specimens. However, CD26, in combination with other T-cell markers, can be helpful for identifying aberrant population clusters in T-cell lymphomas. q 2008 Clinical Cytometry

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Section: Cd26 Expression In T Cells In Tissues and Body Fluidssupporting

confidence: 92%

mentioning

confidence: 99%

Utility of CD26 in flow cytometric immunophenotyping of T‐cell lymphomas in tissue and body fluid specimens

Pierson

Jones

Muzzafar³

et al. 2008

Cytometry Part B Clinical

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“…85 Evidence of the absence of CD7 expression on the CD4 þ cells of Sezary syndromes is extremely pertinent, and may be associated with the evidence of the absence of CD26, although this latter feature seems more controversial. 86,87 CD10 expression has also been reported on angioimmunoblastic T-cell lymphomas. 88 Search for CD30 is of great value, associated with morphology and clinical features, in the diagnosis of Hodgkin's and anaplastic T-cell lymphomas.…”

Section: Additional Useful Markersmentioning

confidence: 87%

Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10

et al. 2011

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The European LeukemiaNet (ELN), workpackage 10 (WP10) was designed to deal with diagnosis matters using morphology and immunophenotyping. This group aimed at establishing a consensus on the required reagents for proper immunophenotyping of acute leukemia and lymphoproliferative disorders. Animated discussions within WP10, together with the application of the Delphi method of proposals circulation, quickly led to post-consensual immunophenotyping panels for disorders on the ELN website. In this report, we established a comprehensive description of these panels, both mandatory and complementary, for both types of clinical conditions. The reason for using each marker, sustained by relevant literature information, is provided in detail. With the constant development of immunophenotyping techniques in flow cytometry and related software, this work aims at providing useful guidelines to perform the most pertinent exploration at diagnosis and for follow-up, with the best cost benefit in diseases, the treatment of which has a strong impact on health systems.

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“…Often, these peripheral blood cells show loss of T-cell antigens, most commonly CD7 and CD26 23 (demonstrable by flow cytometry), but may also show loss of CD2, CD3, CD4, and CD5. Expression of the antigen PD-1 (programmed death-1) is reported as a reliable marker of Sezary cells.…”

Section: And Cd8mentioning

confidence: 99%

Best Practices in Diagnostic Immunohistochemistry: Workup of Cutaneous Lymphoid Lesions in the Diagnosis of Primary Cutaneous Lymphoma

Dewar¹,

Andea²,

Guitart³

et al. 2015

Archives of Pathology & Laboratory Medicine

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Context.-Primary cutaneous lymphoma is a common extranodal non-Hodgkin lymphoma. These lesions share common features with their nodal counterparts, but also have differences in morphology, unique clinical presentations, and immunohistochemical features.Objective. - Data Sources.-The WHO and EORTC classification publications and the relevant recent literature were used to compile appropriate and practical guidelines in this review.Conclusions.-The practice of dermatopathology and hematopathology varies widely. Thus, while this review provides an overview and guideline for the workup of lymphoid lesions of the skin, the practitioner should understand the importance of clinical correlation as well as appropriate utility of available resources (such as clonality testing) in arriving at a diagnosis in cutaneous lymphoid lesions.

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The Usefulness of CD26 in Flow Cytometric Analysis of Peripheral Blood in Sézary Syndrome

Cited by 64 publications

References 2 publications

Utility of CD26 in flow cytometric immunophenotyping of T‐cell lymphomas in tissue and body fluid specimens

Utility of CD26 in flow cytometric immunophenotyping of T‐cell lymphomas in tissue and body fluid specimens

Immunophenotyping of acute leukemia and lymphoproliferative disorders: a consensus proposal of the European LeukemiaNet Work Package 10

Best Practices in Diagnostic Immunohistochemistry: Workup of Cutaneous Lymphoid Lesions in the Diagnosis of Primary Cutaneous Lymphoma

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