The usefulness of C-reactive protein as a biomarker in predicting neonatal sepsis in a sub-Saharan African region

Bunduki, Gabriel Kambale; Adu‐Sarkodie, Yaw

doi:10.1186/s13104-020-05033-1

Cited by 15 publications

(13 citation statements)

References 21 publications

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“…These findings are similar to a study done by Bunduki et al where the sensitivity and positive predictive value of CRP in identifying neonatal sepsis with positive blood culture were 95.7% and 70.2% respectively. 13 In this study, three cases with proven sepsis had a negative CRP. This can be explained by the fact that CRP has the ability to decrease with the rate of resolving of tissue damage.…”

Section: Discussionmentioning

confidence: 63%

C-reactive protein as a diagnostic marker of neonatal sepsis in association with blood culture a retrospective study at a tertiary care hospital

Rati¹,

Singhal

Jaggi³

2021

IJMR

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To evaluate the sensitivity and specificity of C-Reactive protein as a single diagnostic inflammatory biomarker of neonatal sepsis in association with the blood culture.In this study, we retrospectively reviewed the medical records of 330 neonates at a tertiary care hospital at Gurugram from Jan, 2015 to Dec, 2020. The study population included neonates <1month age. Neonates meeting the IPSC criteria (Sepsis 2.0)1 and with a positive culture were considered as neonates with proven sepsis. Neonates with congenital malformations and congenital infections associated with TORCH complex were excluded from the study.Of the 330 neonates screened for sepsis, 32 (10%) had a positive blood culture with raised CRP in 69 (21%) cases. Among the 32 cases with positive blood culture, CRP identified 29 cases. The sensitivity, specificity, positive predictive value, negative predictive values of CRP were 90.6%, 86.5%, 42% and 99% respectively. The area under the curve (AUC) for the CRP ROC analysis was 0.83 with sensitivity of 90.6% and specificity of 91.6% which showed CRP usefulness as the diagnostic inflammatory biomarker of neonatal sepsis.Prematurity (53%) in neonates was the most common risk factor associated with neonatal sepsis. Klebsiella pneumoniae 11 (34%) was the most common pathogen isolated with 73% susceptibility to Ciprofloxacin.C-Reactive protein was found to have a high diagnostic value in terms of sensitivity of 90.6% and specificity of 91.6% when 0.83 is used as a cut off point for diagnosis of neonatal sepsis. Therefore, CRP could be used as diagnostic inflammatory biomarker in resource poor settings.

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Section: Discussionmentioning

confidence: 63%

C-reactive protein as a diagnostic marker of neonatal sepsis in association with blood culture a retrospective study at a tertiary care hospital

Rati¹,

Singhal

Jaggi³

2021

IJMR

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“…Outros adjuvantes potenciais futuros promissores são a metabolômica (BROMIKER et al, 2020). (Bunduki;Adu-Sarkodie, 2020).…”

Section: Discussionunclassified

Caracterização dos fatores de risco e ocorrência de óbito em recém-nascidos com diagnóstico de sepse neonatal em uma Unidade de Terapia Intensiva Neonatal

Oliveira

Boa‐Sorte

2022

RSD

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A sepse neonatal é uma das principais causas de morte de recém-nascidos. O conhecimento prévio dos fatores de risco são fundamentais para prevenir a morbimortalidade. Este estudo tem como objetivo caracterizar os fatores de risco observados e sua relação com a ocorrência de óbito em recém-nascidos com diagnóstico de sepse. Realizou-se um estudo transversal com análise de 712 participantes internados no período de setembro de 2018 a junho de 2020. Foram incluídos 410 neonatos sendo de maior proporção os do sexo masculinos, nascidos com via de parto artificial e baixo peso. A prevalência de óbito observada foi de 6,3% sendo significativa especialmente entre os com prematuridade moderada e extrema, os nascidos de mães adolescentes ou com mais idade de 40 anos, os com hipertemia, baixo peso, bradicardia e maiores tempo de internamento. Encontrou-se uma baixa frequência de hemocultura realizadas. Embora não tenha sido observado predomínio dos achados clínicos característicos da sepse como hipotermia, alterações do leucograma, contagem de plaquetas e níveis de PCR, os achados robustos de maior associação de extremo baixo peso ao nascer, hipertermia e taquipneia a maior frequência de óbito reforçam a qualidade dos dados obtidos.

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“…Laboratory criteria include high immature-to-total neutrophil ratio, low platelet count, high/low white blood cell counts, hypoglycemia/hyperglycemia, metabolic acidosis [base excess (less than À10 mEq/L) or an elevated serum lactate (>2 mmol/L)] (32,35). Furthermore, acute-phase proteins such as C-reactive protein (CRP) and procalcitonin can be elevated in response to neonatal infection and are often used to corroborate LOI (32,36,37). After infection, proinflammatory cytokines, specifically interleukin (IL)-6, enhance hepatic synthesis of CRP in the late stages of neonatal sepsis, i.e., serum CRP is usually increased 6-8 h after the onset of symptoms (38).…”

Section: Preterm Infantsmentioning

confidence: 99%

Influence of innate immune activation on endocrine and metabolic pathways in infancy

O’Connor

Ashoori

Dias

et al. 2021

American Journal of Physiology-Endocrinology and Metabolism

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Prematurity is the leading cause of neonatal morbidity and mortality worldwide. Premature infants often require extended hospital stays, with increased risk of developing infection compared with term infants. A picture is emerging of wide-ranging deleterious consequences resulting from innate immune system activation in the newborn infant. Those who survive infection have been exposed to a stimulus that can impose long-lasting alterations into later life. In this review, we discuss sepsis-driven alterations in integrated neuroendocrine and metabolic pathways and highlight current knowledge gaps in respect of neonatal sepsis. We review established biomarkers for sepsis and extend the discussion to examine emerging findings from human and animal models of neonatal sepsis that propose novel biomarkers for early identification of sepsis. Future research in this area is required to establish a greater understanding of the distinct neonatal signature of early and late-stage infection, to improve diagnosis, curtail inappropriate antibiotic use and promote precision medicine through a biomarker-guided empirical and adjunctive treatment approach for neonatal sepsis. There is an unmet clinical need to decrease sepsis-induced morbidity in neonates, to limit and prevent adverse consequences in later life and decrease mortality.

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The usefulness of C-reactive protein as a biomarker in predicting neonatal sepsis in a sub-Saharan African region

Cited by 15 publications

References 21 publications

C-reactive protein as a diagnostic marker of neonatal sepsis in association with blood culture a retrospective study at a tertiary care hospital

C-reactive protein as a diagnostic marker of neonatal sepsis in association with blood culture a retrospective study at a tertiary care hospital

Caracterização dos fatores de risco e ocorrência de óbito em recém-nascidos com diagnóstico de sepse neonatal em uma Unidade de Terapia Intensiva Neonatal

Influence of innate immune activation on endocrine and metabolic pathways in infancy

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