The usefulness of a new rapid diagnostic test, the First Response® Malaria Combo (pLDH/HRP2) card test, for malaria diagnosis in the forested belt of central India

Bharti, Praveen K.; Silawat, N.; Singh, Pushpendra; Singh, Mrigendra P.; Shukla, Man Mohan; Chand, Gyan; Dash, A. P.; Singh, Neeru

doi:10.1186/1475-2875-7-126

Cited by 68 publications

(53 citation statements)

References 26 publications

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“…Bharti PK et al 13 had shown that rapid antigen testing for malaria was highly efficacious in comparison to microscopy. We had found similar result.…”

Section: Discussionmentioning

confidence: 99%

Severe vivax malaria in Eastern India

Mukherjee¹,

Chakrabarty

2015

Asian J Med Sci

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Background: Conventionally, vivax malaria was called as benign malaria. But recent reports of severe vivax malaria were coming from different parts of the World. We studied to find out different attributes of patients, suffering from Plasmodium vivax to reveal some key pattern of severe vivax malaria. Methods: Retrospective, observational and cross-sectional study was conducted comprising first hundred malaria indoor cases in a tertiary hospital in Kolkata, India, having unstable transmission. Their various parameters were noted in MS-Excel software. Malaria species was identified and severe malaria cases were noted according to WHO criteria. Data was analysed with GraphPad Instat Software. Results: Among 57 vivax malaria cases, 16 (28.1%) were having severe malaria and among 32 falciparum malaria cases, 11 (34.4%) were having severe malaria; without significant difference between two species in incidence of severe malaria manifestations. Two (18.2%) patients suffering from mixed malaria had severe malaria. Jaundice was the commonest severe malaria manifestation. Conclusion: Incidence of severe vivax malaria was high. Severe malaria manifestations were present in vivax and falciparum cases, without significant difference.

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“…Bharti PK et al 13 had shown that rapid antigen testing for malaria was highly efficacious in comparison to microscopy. We had found similar result.…”

Section: Discussionmentioning

confidence: 99%

Severe vivax malaria in Eastern India

Mukherjee¹,

Chakrabarty

2015

Asian J Med Sci

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“…Diagnosis was carried out at the community level by CHWs at health facilities, private clinics or health facilities run by non-government organizations (NGOs) or faith-based organizations. The study looked at all cases of malaria reported in the health facilities categorizing the data into i) clinically diagnosed malaria based on fever and other clinical signs; and ii) confirmed malaria diagnosis, either through microscopy or by RDT using the Malaria Ag P.f/Pan test (Standard Diagnostics, Yongin-si, Republic of Korea), a test for the Plasmodium falciparum histidine-rich protein II antigen and the Plasmodium lactate dehydrogenase constituent (Bharti et al, 2008;Keating et al 2009;Kamuliwo et al, 2013).…”

Section: Malaria Data and Managementmentioning

confidence: 99%

“…A revision of the treatment regimen for both uncomplicated and complicated malaria was released in 2014, adding artemether-lumefantrine (AL) to ACT as first line of treatment (NMCC, 2014) to be given within 24 hours of onset of symptoms. However, the use of rapid diagnostic tests (RDTs) was first initiated as a pilot project in some districts in 2005 to 2006 (Bharti et al, 2008) and was scaled up for country-wide use in 2008 (Keating et al, 2009). In 2009, Zambia began separate reporting for clinical and parasitological diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic approaches to malaria in Zambia, 2009-2014

et al. 2015

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Malaria is an important health burden in Zambia with proper diagnosis remaining as one of the biggest challenges. The need for reliable diagnostics is being addressed through the introduction of rapid diagnostic tests (RDTs). However, without sufficient laboratory amenities in many parts of the country, diagnosis often still relies on non-specific, clinical symptoms. In this study, geographical information systems were used to both visualize and analyze the spatial distribution and the risk factors related to the diagnosis of malaria. The monthly reported, district-level number of malaria cases from January 2009 to December 2014 were collected from the National Malaria Control Center (NMCC). Spatial statistics were used to reveal cluster tendencies that were subsequently linked to possible risk factors, using a non-spatial regression model. Significant, spatio-temporal clusters of malaria were spotted while the introduction of RDTs made the number of clinically diagnosed malaria cases decrease by 33% from 2009 to 2014. The limited access to road network(s) was found to be associated with higher levels of malaria, which can be traced by the expansion of health promotion interventions by the NMCC, indicating enhanced diagnostic capability. The capacity of health facilities has been strengthened with the increased availability of proper diagnostic tools and through retraining of community health workers. To further enhance spatial decision support systems, a multifaceted approach is required to ensure mobilization and availability of human, infrastructural and technological resources. Surveillance based on standardized geospatial or other analytical methods should be used by program managers to design, target, monitor and assess the spatio-temporal dynamics of malaria diagnostic resources country-wide.

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“…Although the authors acknowledged that their data can only be narrowly interpreted to indicate that heat stability can sometimes be a problem for tests, a number of subsequent authors have concluded that pLDH-based tests in general are inherently unstable in heat. 48,[50][51][52][53] Without delving into the cause of particular discrepancies, making general interpretations from comparative studies will be limited and confined to assessing one product over another. Although many studies of particular products conclude the that pLDH tests have greater specificity but equal or inferior sensitivity compared with HRP-2-based tests, 51,53,54 studies using different products have shown both superior sensitivity and specificity compared with popular HRP-2-based tests.…”

Section: The Practice Of Rdtsmentioning

confidence: 99%

Rapid Malaria Tests: Where Do We Go After 20 Years?

Makler¹,

Piper²

2009

The American Journal of Tropical Medicine and Hygiene

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Abstract. Great advances have been made in developing rapid diagnostic tests (RDTs) for diagnosing malaria. To date, RDTs present an exceedingly practical format for malaria diagnosis that outperforms traditional microscopy and more experimental next generation devices in the development pipeline. However, although use of such tests is accepted in principle, their actual use has lagged. Furthermore, study of how these tests perform, what their limitations are, and how to work with these limitations to still use them effectively has stagnated. We propose that the study and implementation of such RDTs should be aggressively advanced and propose a series of questions that can guide efforts.

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The usefulness of a new rapid diagnostic test, the First Response® Malaria Combo (pLDH/HRP2) card test, for malaria diagnosis in the forested belt of central India

Cited by 68 publications

References 26 publications

Severe vivax malaria in Eastern India

Severe vivax malaria in Eastern India

Diagnostic approaches to malaria in Zambia, 2009-2014

Rapid Malaria Tests: Where Do We Go After 20 Years?

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