The use of vitamin K supplementation to achieve INR stability: A systematic review and meta-analysis

Kramps, Melissa; Flanagan, Abigail; Smaldone, Arlene

doi:10.1111/1745-7599.12022

Cited by 4 publications

(4 citation statements)

References 29 publications

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“…Besides bleeding, oral anticoagulation therapy can have other complications and significant interactions with other medications and other disease states (Kramps et al . ). Consequences can also arise due to nonadherence (Rose et al .…”

Section: Introductionmentioning

confidence: 97%

“…OAT with vitamin K-antagonists (phenprocoumon, acenocoumarol or dicoumarol) is a common medical treatment for such diseases. Besides bleeding, oral anticoagulation therapy can have other complications and significant interactions with other medications and other disease states (Kramps et al 2013). Consequences can also arise due to nonadherence (Rose et al 2009).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Implementing evidence‐based patient and family education on oral anticoagulation therapy: a community‐based participatory project

Shaha

Wüthrich

Stauffer

et al. 2015

Journal of Clinical Nursing

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Implementing evidence‐based patient and family education on oral anticoagulation therapy: a community‐based participatory project

Shaha

Wüthrich

Stauffer

et al. 2015

Journal of Clinical Nursing

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“…Low-dose supplements of MK-7 could also improve the anticoagulant management in patients ( 39 ). However, not all patients benefit from VK supplementation, and the dose supplementation of VK improves the stability of VKA therapy in patients with unstable INR only ( 45 ).…”

Section: Vitamin K and Anticoagulant Therapymentioning

confidence: 99%

The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism

et al. 2022

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The vitamin K antagonist is a commonly prescribed effective oral anticoagulant with a narrow therapeutic range, and the dose requirements for different patients varied greatly. In recent years, studies on human intestinal microbiome have provided many valuable insights into disease development and drug reactions. A lot of studies indicated the potential relationship between microbiome and the vitamin K antagonist. Vitamin K is absorbed by the gut, and the intestinal bacteria are a major source of vitamin K in human body. A combined use of the vitamin K antagonist and antibiotics may result in an increase in INR, thus elevating the risk of bleeding, while vitamin K supplementation can improve stability of anticoagulation for oral vitamin K antagonist treatment. Recently, how intestinal bacteria affect the response of the vitamin K antagonist remains unclear. In this review, we reviewed the research, focusing on the physiology of vitamin K in the anticoagulation treatment, and investigated the potential pathways of intestinal bacteria affecting the reaction of the vitamin K antagonist.

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“…Characterizing the contribution of these additional food sources of vitamin K is critical for developing dietary recommendations for the US population as a whole but also for clinical populations, such as individuals receiving vitamin K antagonist anticoagulant therapy (coumarin-based oral anticoagulants). The direct drug-nutrient interaction influences drug efficacy and dosing (7), and changes in dietary vitamin K intake can result in adverse events, including over-anticoagulation or severe clotting (8). Individuals initiating or continuing therapy receive counseling to maintain a diet with consistent vitamin K intake to ensure anticoagulant stability, demonstrating the importance of accurately identifying dietary sources of vitamin K.…”

Section: Introductionmentioning

confidence: 99%

Vegetables and Mixed Dishes Are Top Contributors to Phylloquinone Intake in US Adults: Data from the 2011-2012 NHANES

Harshman

Finnan

Barger

et al. 2017

The Journal of Nutrition

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Phylloquinone is the most abundant form of vitamin K in US diets. Green vegetables are considered the predominant dietary source of phylloquinone. As our food supply diversifies and expands, the food groups that contribute to phylloquinone intake are also changing, which may change absolute intakes. Thus, it is important to identify the contributors to dietary vitamin K estimates to guide recommendations on intakes and food sources. The purpose of this study was to estimate ) the amount of phylloquinone consumed in the diet of US adults,) to estimate the contribution of different food groups to phylloquinone intake in individuals with a high or low vegetable intake (≥2 or <2 cups vegetables/d), and ) to characterize the contribution of different mixed dishes to phylloquinone intake. Usual phylloquinone intake was determined from NHANES 2011-2012 (≥20 y old; 2092 men and 2214 women) and the National Cancer Institute Method by utilizing a complex, stratified, multistage probability-cluster sampling design. On average, 43.0% of men and 62.5% of women met the adequate intake (120 and 90 μg/d, respectively) for phylloquinone, with the lowest self-reported intakes noted among men, especially in the older age groups (51-70 and ≥71 y). Vegetables were the highest contributor to phylloquinone intake, contributing 60.0% in the high-vegetable-intake group and 36.1% in the low-vegetable-intake group. Mixed dishes were the second-highest contributor to phylloquinone intake, contributing 16.0% in the high-vegetable-intake group and 28.0% in the low-vegetable-intake group. Self-reported phylloquinone intakes from updated food composition data applied to NHANES 2011-2012 reveal that fewer men than women are meeting the current adequate intake. Application of current food composition data confirms that vegetables continue to be the primary dietary source of phylloquinone in the US diet. However, mixed dishes and convenience foods have emerged as previously unrecognized but important contributors to phylloquinone intake in the United States, which challenges the assumption that phylloquinone intake is a marker of a healthy diet. These findings emphasize the need for the expansion of food composition databases that consider how mixed dishes are compiled and defined.

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The use of vitamin K supplementation to achieve INR stability: A systematic review and meta-analysis

Cited by 4 publications

References 29 publications

Implementing evidence‐based patient and family education on oral anticoagulation therapy: a community‐based participatory project

Implementing evidence‐based patient and family education on oral anticoagulation therapy: a community‐based participatory project

The Relationship Among Intestinal Bacteria, Vitamin K and Response of Vitamin K Antagonist: A Review of Evidence and Potential Mechanism

Vegetables and Mixed Dishes Are Top Contributors to Phylloquinone Intake in US Adults: Data from the 2011-2012 NHANES

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