The use of vasopressors in Takotsubo cardiomyopathy: Impact on neurological practice

The use of dopamine in Takotsubo cardiomyopathy

“…We thank Rathakrishnan et al for their comments [1] on our article [2]. Lyon et al [3] hypothesized that Takotsubo cardiomyopathy is the result of the direct effects of high levels of epinephrine on the ventricular myocardium: high levels of epinephrine after stressful stimuli switch β 2 -receptor coupling in ventricular cardiomyocytes, from the Gs protein to the Gi protein signaling pathway, resulting in a negative inotropic effect in the apical myocardium, where the β-receptor density is greatest, and this effect is reversible after the epinephrine levels return to normal.…”