The use of vancomycin and tobramycin in acrylic bone cement

Klekamp, John; Dawson, J. M.; Haas, David W.; DeBoer, David K.; Christie, Michael J.

doi:10.1016/s0883-5403(99)90061-x

Cited by 188 publications

(48 citation statements)

References 24 publications

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“…An example of this flaw in study design is seen in studies that compare Simplex P [in which the powder beads are a mixture of PMMA and P(MMA, S) and the radiopacifier is BaSO 4 ], on the one hand, and either Palacos R or Osteopal (in which the polymerized polymer powder beads and radiopacifier are PMMA and ZrO 2 , respectively), on the other. 31,32,62,74,84 In other words, in these studies, the cements compared have differences in more than one basic constituent; thus, no clear conclusion may be drawn regarding the role of basic composition. In a few literature studies 60,65,75 the cements that were compared have the same basic constituents; this ensured that any differences in fatigue performance of these cements is not likely to be due to differences in their basic compositions.…”

Section: Effect Of Intrinsic Factors Basic Composition Of the Cementmentioning

confidence: 89%

“…In contrast, significant decreases in fatigue life have been reported for (a) centrifugation-mixed Palacos R when gentamicin was added; 32 and (b) vacuum-mixed Simplex P when vancomycin or tobramycin was added. 62 Based on these results, 32,36,62 it is, at this time, unclear what impact inclusion of an antibiotic in a cement has on its fatigue life.…”

Section: Inclusion Of An Antibiotic In the Powdermentioning

confidence: 99%

“…For example, Davies et al 21 stated that "specimens which contained large voids were not tested." Klekamp et al 62 radiographically inspected the fabricated specimens and "samples with large voids were discarded." (In both of these reports, the workers did not define what constituted large voids.)…”

Section: Test Specimen Selection Criterionmentioning

confidence: 99%

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Fatigue testing and performance of acrylic bone‐cement materials: State‐of‐the‐art review

Lewis

2003

J Biomed Mater Res

101

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Over the past three decades or so, a very large volume of literature has been generated on the impact of an assortment of variables on the fatigue lifetimes of a large number of acrylic bone-cement formulations. In the present article, this literature is examined critically to reveal areas of agreement, areas of disagreement, as well as a welter of underexplored and unexplored topics. For example, there is unanimity of support for the notion that an increase in the molecular weight of the powder constituents or the fully cured cement leads to an increase in the cement's fatigue life, whereas there is disagreement as to whether vacuum mixing the cement constituents leads to an increase in the fatigue life of the fully cured cement (relative to the hand-mixed counterpart). Among the underexplored topics is systematic study of the effect of test frequency on the fatigue results, whereas determination of the optimal concentration of the antibiotic in an antibiotic-loaded cement is an example of the unexplored topics. It is pointed out that resolving the controversies, addressing the underexplored topics, and filling the lacunae will allow comprehensive evaluations of acrylic bone-cement materials to be made. This enhanced body of knowledge will prove invaluable in the continued use of acrylic bone cement as the anchoring agent in cemented arthroplasties.

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Section: Effect Of Intrinsic Factors Basic Composition Of the Cementmentioning

confidence: 89%

Section: Inclusion Of An Antibiotic In the Powdermentioning

confidence: 99%

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Fatigue testing and performance of acrylic bone‐cement materials: State‐of‐the‐art review

Lewis

2003

J Biomed Mater Res

101

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“…The holes then were filled with antibiotic-impregnated bone cement (Palacos R) to simulate the worst case. 12,16 In pilot tests, moisture was found to have no mechanically relevant effect, and therefore additional testing was done only under dry conditions.…”

Section: Pull-out Strength Of Different Suture Materials From Bone Cementioning

confidence: 99%

“…The holes were filled with antibioticimpregnated cement (Palacos R) to simulate the worst case. 12,16 After curing of the cement, the sutures were loaded perpendicularly to the cement surface until failure occurred, as above. In cases where single loops of suture were loaded, both suture ends were pulled simultaneously.…”

Section: Pull-out Strength Of Braided Polyester Number 3 Sutures Frommentioning

confidence: 99%

The Use of Acrylic Bone Cement for Suture Anchoring

Meyer

Jacob²,

Pistoia³

et al. 2003

Clinical Orthopaedics &Amp; Related Research

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Healing of tendon or ligament sutured to bone depends among other parameters on the mechanical stability of the suture fixation in or to the bone. The authors propose a method of anchoring suture material using bone cement as a substitute for conventional suture anchors. Conditions for secure fixation of suture material in bone cement were assessed and the technique of anchoring suture material with acrylic cement in bone was developed. Mechanical testing and microcomputed tomography of the suture-cement-bone compound were done. It was found that the suture always should be knotted before embedding it at least 2 mm deep in the bone cement. The holes drilled into the bone in which the sutures are secured with cement should be at least 3.5 mm in diameter and 10 mm deep; in cortical bone a tapped thread is required. Sutures can be secured safely using cement anchors which provide higher pull-out strength of a factor two to five than conventional metallic suture anchors of comparable size. They also adapt to anatomic situations where conventional anchors cannot be used and are more favorable in osteoporotic bone. Cement anchoring of sutures seems to be a cost-effective and valuable alternative when there is poor bone quality or extraordinarily high mechanical load.

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Toward standardization of methods of determination of fracture properties of acrylic bone cement and statistical analysis of test results

Lewis

Nyman

2000

J. Biomed. Mater. Res.

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A succinct critical review of the literature on the fatigue, fatigue crack propagation, and fracture toughness (herein collectively termed "fracture properties") of acrylic bone cement is presented, whereby it is pointed out that a plethora of test conditions have been used. This situation precludes meaningful interstudy comparisons and mitigates against a definitive delineation of the effect of a named variable on a specified fracture property. A case for standardization of test conditions is thus made, culminating in the presentation of a recommended set of such conditions. In addition, it is shown that many literature parametric studies employed inappropriate statistical methods for performing pairwise comparisons, and all these studies have not addressed the issue of possible interactions between the parameters being investigated. A methodology for addressing these deficiencies is presented in the present report, and its use is illustrated with a set of notional fatigue test results.

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The use of vancomycin and tobramycin in acrylic bone cement

Cited by 188 publications

References 24 publications

Fatigue testing and performance of acrylic bone‐cement materials: State‐of‐the‐art review

Fatigue testing and performance of acrylic bone‐cement materials: State‐of‐the‐art review

The Use of Acrylic Bone Cement for Suture Anchoring

Toward standardization of methods of determination of fracture properties of acrylic bone cement and statistical analysis of test results

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