The Use of Torbangun Leaf Powder (Coleus amboinicus L) in Increasing Prolactin in Breastfeedings Wistar Rats and Bodyweight of the Litters

Abstract

Research on local herbs that have the effect of increasing breast milk production isneeded to help mothers with insufficient breastmilk. This research was conducted to determinethe effect of torbangun (Coleus amboinicus L) leaf powder in increasing prolactin inbreastfeeding Wistar rats and the bodyweight of the litters. Thirty breastfeeding Wistar rats weredivided into 5 groups with 5 litters each. The treatments given were 108 mg, 216 mg, and 432 mgtorbangun leaf powder (TLP), with domperidone as the positive control, and CMC 10% as thenegative control. The treatment was given 3 times/day for 14 days. Tukey's HSD means testshowed a significant difference in prolactin levels between the negative control (NC), TLP1, andTLP2 groups and the TLP3 and positive control (PC) groups with all of them having p = 0.000.There was no difference in the increase in body weight of litters between treatment groups (p =0.866). In conclusion, torbangun leaves increase the prolactin levels in breastfeeding rats buthave no difference in the increase in body weight of litters between treatment groups.
 Keywords: torbangun leaves; prolactin; bodyweight; breastfeeding

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Narrative Review of Known Plants which Have Potential Benefits as Natural Galactagogues in Indonesia

“…The suggested dosage for lactating mothers was 3x50 g torbangun simplicia per day, and the LD 50 (50% lethal dose) was more than 5000 mg/kg of body weight in the rat (Kemenkes, 2016). Table 3 summarized selected in vivo studies of torbangun leaves as a galactagogue using lactating rats (Damanik et al, 2017;Hasianna et al, 2021;Hutajulu and Junaidi 2013;Iwansyah et al, 2017) and humans (Herlina, 2018;Santosa, 2001). Hasianna et al (2021) showed that 432 mg of dried torbangun leaves had the most signifi cant effect on increasing prolactin level compared to the negative control, 108 mg, and 216 mg of dried torbangun leaves.…”

“…Table 3 summarized selected in vivo studies of torbangun leaves as a galactagogue using lactating rats (Damanik et al, 2017;Hasianna et al, 2021;Hutajulu and Junaidi 2013;Iwansyah et al, 2017) and humans (Herlina, 2018;Santosa, 2001). Hasianna et al (2021) showed that 432 mg of dried torbangun leaves had the most signifi cant effect on increasing prolactin level compared to the negative control, 108 mg, and 216 mg of dried torbangun leaves. There was no signifi cant difference in the weight gain of the pups.…”