The use of the thrombodynamics test in the diagnostics of hemostasis disorders in patients with COVID-19 of varying severity

Abstract

Background: At the moment, an urgent and unresolved problem is the search for a diagnostic method for disorders of the hemostasis system in patients against the background of the course of a new coronavirus infection. Presumably, integral tests, in particular, the thrombodynamics test, will make it possible to monitor changes in blood clotting, predict the course of the disease in patients with COVID-19.
 Aims: to comparative assessment of plasma hemostasis parameters and thrombodynamics test in patients with COVID-19 viral infection of varying severity.
 Methods: The study included 96 patients with a confirmed diagnosis of COVID-19, hospitalized in an infectious diseases hospital on the basis of National Medical Research Center for Obstetrics, Gynecology and Perinatology named after V.I. Kulakov in the period from 04.23.2020 to 06.20.2020 and discharged at the end of treatment. SARS-CoV-2 was identified by PCR. Patients were stratified by severity into 3 groups: mild course (n = 25), moderate course (n = 54), severe course (n = 17). Diagnostics and treatment of patients was carried out in accordance with the Temporary Methodological Recommendations of the Ministry of Health of the Russian Federation for the prevention, diagnosis and treatment of new coronavirus infection, versions 5, 6, 7. In the dynamics of treatment, patients were assessed APTT, prothrombin %, prothrombin time and thrombin time, fibrinogen, D-dimer, platelet count and thrombodynamic test (V / Vi / Vst, Tlag, Cs, D).
 Results: It was found that significant differences before admission and a week after the start of hospital treatment were observed for the thrombin time, D-dimer, platelet count, and thrombodynamic parameters: V / Vst, Cs, D. PT, APTT, TD (Tlag, D)) with the duration of hospital stay. There was a positive relationship between the content of fibrinogen and D (r = 0.6307, p 0.0001) and a strong positive relationship between PT and Tlag (r = 0.7499, p 0.0001).
 Conclusions: The thrombodynamics test can be recommended as a potential tool for a personalized approach to monitoring the hemostasis system and treating patients with COVID-19.

Von Willebrand Factor and ADAMTS-13 Are Associated with the Severity of COVID-19 Disease

“…The study was carried out at: National Medical Research Center for Obstetrics, Gynecology and Perinatology, named after Academician V.I.Kulakov of the Ministry of Healthcare of the Russian Federation, Moscow, Russia F.I. Inozemtsev City Clinical Hospital, Moscow, Russia A database containing information on 18 patients with a severe form of COVID-19 complicated by a feasibility study that was provided by Ataullakhanov Fazoil Inoyatovich (CTP FHF RAS, research work “Use of the Thrombodynamics test in COVID-19: identification of early predictors of the development of severe pneumonia and development of effective measures for its prevention”, registration number: AAAA-A20-120111090014-6) [ 14 ]. …”

“…A database containing information on 18 patients with a severe form of COVID-19 complicated by a feasibility study that was provided by Ataullakhanov Fazoil Inoyatovich (CTP FHF RAS, research work “Use of the Thrombodynamics test in COVID-19: identification of early predictors of the development of severe pneumonia and development of effective measures for its prevention”, registration number: AAAA-A20-120111090014-6) [ 14 ].…”