The use of the SeDeM Diagram expert system to determine the suitability of diluents–disintegrants for direct compression and their use in formulation of ODT

Aguilar-Díaz, Johnny Edward; García-Montoya, Encarnación; Pérez-Lozano, Pilar; Suñé-Negre, Josep M.; Carmona, Montserrat Miñarro; Grau, Josep R. Ticó

doi:10.1016/j.ejpb.2009.07.001

Cited by 62 publications

(38 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The 'SeDeM-ODT' expert system has 12 parameters (bulk density, tapped density, inter-particle porosity, Carr index, cohesion index, Hausner ratio, angle of repose, powder flow, loss on drying, hygroscopicity, particle size, homogeneity index ) which classified into 5 factors (dimensions, compressibility, flowability/powder flow, lubricity/stability, lubricity/dosage) to determine the index of good compression (IGC). That complies to analyse the suitability of 43 excipients for direct compression manufacturing method [42]. …”

Section: Volume 3 | Issuementioning

confidence: 96%

Orally Disintegrating Tablets: A Short Review

Fb¹,

Uğurlu²

2015

Journal of Pharmaceutics and Drug Development

View full text Add to dashboard Cite

Section: Volume 3 | Issuementioning

confidence: 96%

Orally Disintegrating Tablets: A Short Review

Fb¹,

Uğurlu²

2015

Journal of Pharmaceutics and Drug Development

View full text Add to dashboard Cite

“…Using the equation proposed by Suñé et al (6), the corrective concentration of Ludiflash ® necessary to compress the active substance was calculated according the equation (6):…”

Section: Formulation Of Ibuprofen 100 Mg Odt Tabletsmentioning

confidence: 99%

“…Recent studies used SeDeM Diagrams to characterize a large number of disintegrants in order to verify their suitability for preparing ODTs by direct compression (6). It has also been shown that two newly introduced parameters, Index of Good Compressibility (IGC) and Index of Good Compressibility Bucodispersibility (IGCB), make it possible the calculate the quantity of superdisintegrant that enables both direct compressibility and suitable disintegration times (less than 3 minutes) (7,8).…”

mentioning

confidence: 99%

Application of SeDeM expert systems in preformulation studies of pediatric ibuprofen ODT tablets

et al. 2017

View full text Add to dashboard Cite

Pediatric, ibuprofen containing orodispersible tablets (ODTs) were prepared using the SeDeM expert system methodology. In order to facilitate formulation, directly compressible ibuprofen was employed (Ibuprofen DC 85™) and characterized using its SeDeM profile. The mannitol based superdisintegrant Ludiflash ® was characterized by the SeDeM-ODT expert system, which also allowed calculation of the optimal excipient concentration in order to obtain suitable tablet hardness and disintegration time. After adding a sweetener and a standard combination of lubricants, the optimized formulation was directly compressed into tablets and evaluated in terms of tablet hardness, friability, disintegration time and dissolution profile. The SeDeM method was applied to determine the amount of corrective excipient (Ludiflash ® ) required for the compression of Ibuprofen DC 85™ in order to achieve suitable ODTs. Adequate tablet hardness, disintegration time, friability and dissolution profiles were found during tablet evaluation.

show abstract

“…SeDeM uses 12 tests (Suñé et al, 2005;García et al, 2010;Aguilar et al, 2009) to examine whether a powder is suitable for direct compression.…”

Section: Parameters Examined By the Sedem Methodsmentioning

confidence: 99%

“…This system informs on the physical profile of powdered substances (APIs and excipients) used to formulate drugs (Suñé et al, 2005;García et al, 2010;Aguilar et al, 2009). By determining whether powders (API or excipient) are suitable for direct compression, the SeDeM profile will inform about the advantages and gaps of those powdered substance to be used in direct compression, so the system informs on whether the direct compression method is appropriate (e.g.. wet granulation should be applied before compression).…”

Section: Introductionmentioning

confidence: 99%