The Use of the RAFT‐Technique for the Preparation of Temperature/pH Sensitive Polymers in Different Architectures

Abstract

Summary: In this contribution we report the use of the RAFT-technique for the preparation of three types of responsive polymeric materials with a high potential of application in the biomedical field: 1.-Diblock copolymers with reversible selfassembly capacity as a function of pH based on N,N 0 -diethylaminoethyl methacrylate (DEAEM) and 2-methacryloyloxy benzoic acid (MAOB); 2.-Diblock copolymers with reversible self-assembly capacity as a function of temperature, based N-isopropylacrylamide (NIPAAm) and n-hexyl acrylate (HA); and 3.-Polymeric stars with random number of arms consisting either in NIPAAm-arms or copolymeric NIPAAm-arms and hydrophobic core.

Semibatch RAFT polymerization for branched polyacrylamide production: Effect of divinyl monomer feeding policies

“…Zheng and Pan prepared PS and PS‐ b ‐poly( N ‐isopropyl acrylamide) (NIPAM) star polymers via RAFT polymerization of St and its successive polymerization with NIPAM followed by copolymerization with DVB. The same method was used to synthesize poly(acrylic acid) stars with fluorescent divinyl comonomer core, poly(N‐isopropyl acrylamide) (PNIPAM) or poly(2‐hydroxyethylmethacrylate) stars with ethyleneglycol dimethacrylate or DVB core, and poly(ethylene oxide) stars with St/DVB microgel core …”

Dextran-covered pH-sensitive oily core nanocapsules produced by interfacial Reversible Addition-Fragmentation chain transfer miniemulsion polymerization

“…We were expecting that these CTA groups were also appropriate for RAFT miniemulsion copolymerization of MMA with DEAEMA. Indeed, RAFT homogeneous homopolymerization of DEAEMA has been successfully performed in ethanol [26], [40] or in 1,4-dioxane [14], [41] using 4-cyanopentanoic acid dithiobenzoate (CPADB) as molecular CTA. In addition, RAFT copolymerizations of DEAEMA with 2-(dimethylamino)ethyl methacrylate [24] or 2-(diisopropylamino)ethyl methacrylate [14] have also been reported in 1,4-dioxane using 2-cyanoprop-2-yl dithiobenzoate (CPDB) and CPADB, respectively.…”