The Use of TEPC for Reference Dosimetry

Lindborg, L.; Kyllönen, J.-E.; Beck, P.; Bottollier-Depois, J.-F.; Gerdung, S.; Grillmaier, R.; Schrewe, U.J.

doi:10.1093/oxfordjournals.rpd.a032959

Cited by 23 publications

(11 citation statements)

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“…The lineal energy can be measured through a microdosimeter detector, where the most frequently used are the tissue-equivalent proportional counters (TEPC) [44][45][46][47]; analogous information can be achieved also by solid-state detectors [48,49] and gas electron multiplier (GEM) detectors [50,51], recently investigated for their use in microdosimetric measurements [52,53]. The relationship between l of the tissue-equivalent volume of the microdosimeter, from which the lineal energy is calculated, and the physical mean chord of the detector, l det , is given approximately by…”

Section: Experimental Quantitiesmentioning

confidence: 99%

Linking Microdosimetric Measurements to Biological Effectiveness in Ion Beam Therapy: A Review of Theoretical Aspects of MKM and Other Models

et al. 2021

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Different qualities of radiation are known to cause different biological effects at the same absorbed dose. Enhancements of the biological effectiveness are a direct consequence of the energy deposition clustering at the scales of DNA molecule and cell nucleus whilst absorbed dose is a macroscopic averaged quantity which does not take into account heterogeneities at the nanometer and micrometer scales. Microdosimetry aims to measure radiation quality at cellular or sub-cellular levels trying to increase the understanding of radiation damage mechanisms and effects. Existing microdosimeters rely on the well-established gas-based detectors or the more recent solid-state devices. They provide specific energy z spectra and other derived quantities as lineal energy (y) spectra assessed at the micrometer level. The interpretation of the radio-biological experimental data in the framework of different models has raised interest and various investigations have been performed to link in vitro and in vivo radiobiological outcomes with the observed microdosimetric data. A review of the major models based on experimental microdosimetry, with a particular focus on ion beam therapy applications and an emphasis on the microdosimetric kinetic model (MKM), will be presented in this work, enlightening the advantages of each one in terms of accuracy, initial assumptions, and agreement with experimental data. The MKM has been used to predict different kinds of radiobiological quantities such as the relative biological effects for cell inactivation or the oxygen enhancement ratio. Recent developments of the MKM will be also presented, including new non-Poissonian correction approaches for high linear energy transfer radiation, the inclusion of partial repair effects for fractionation studies, and the extension of the model to account for non-targeted effects. We will also explore developments for improving the models by including track structure and the spatial damage correlation information, by using the full fluence spectrum and by better accounting for the energy-deposition fluctuations at the intra- and inter-cellular level.

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Section: Experimental Quantitiesmentioning

confidence: 99%

Linking Microdosimetric Measurements to Biological Effectiveness in Ion Beam Therapy: A Review of Theoretical Aspects of MKM and Other Models

et al. 2021

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“…The TEPC is the de facto instrument for microdosimetry [International Commission on Radiation Units and Measurements (ICRU), 1983] and was selected for the RaD-X mission to serve as a flight standard against which the other dosimeters could be compared. TEPCs have been used for many diverse applications on Earth [e.g., Straume et al, 1991;Lindborg et al, 1999;Gersey et al, 2002;Lindborg and Nikjoo, 2011] and in space, including in the Space Shuttle [e.g., Badhwar et al, 1996] and in the International Space Station (ISS) [e.g., Perez-Nunez and Braby, 2011], and compact TEPC designs are being developed for deep-space human missions [Straume et al, 2015].…”

Section: Far West Tissue-equivalent Proportional Countermentioning

confidence: 99%

Ground-based evaluation of dosimeters for NASA high-altitude balloon flight

et al. 2016

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Results are presented from evaluations of radiation dosimeters prior to a NASA high‐altitude balloon flight, the RaD‐X mission. Four radiation dosimeters were on board RaD‐X: a Far West Hawk (version 3), a Teledyne dosimeter (UDOS001), a Liulin dosimeter (MDU 6SA1), and a RaySure dosimeter (version 3b). The Hawk is a tissue‐equivalent proportional counter (TEPC) and the others are solid‐state Si sensors. The Hawk served as the “flight standard” and was calibrated for this mission. The Si‐based dosimeters were tested to make sure they functioned properly prior to flight but were not calibrated for the radiation environment in the stratosphere. The dosimeters were exposed to 60Co gamma rays and 252Cf fission radiation (which includes both neutrons and gamma rays) at the Lawrence Livermore National Laboratory (LLNL). The measurement results were compared with results from standard “benchmark” measurements of the same sources and source‐to‐detector distances performed contemporaneously by LLNL calibration facility personnel. For 60Co gamma rays, the dosimeter‐to‐benchmark ratios were 0.84 ± 0.06, 1.07 ± 0.32, 1.31 ± 0.07, and 0.82 ± 0.24 for the TEPC, Teledyne, Liulin, and RaySure, respectively. For 252Cf radiation, the dosimeter‐to‐benchmark ratios were 0.94 ± 0.15, 0.55 ± 0.18, 0.58 ± 0.08, and 0.33 ± 0.12 for the TEPC, Teledyne, Liulin, and RaySure. Some examples of how the results were used to help interpret the flight data are also presented.

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“…Many groups have performed measurements on board aircraft with a variety of dosemeters, both active and passive, since the publication of ICRP 60 (see, for example Schrewe, 2000 (6) ). However, the aim of this study is to compile a substantial body of measurements using well-characterised tissue-equivalent proportional counters (TEPCs) over a significant fraction of the current solar cycle, not only to validate predictive codes, but also to generate a self-consistent set of data using what is considered to be the best instrument for cosmic ray dosimetry at aircraft altitudes (7) .…”

Section: Aim Of Workmentioning

confidence: 99%

The Evaluation and Use of a Portable TEPC System for Measuring In-flight Exposure to Cosmic Radiation

Taylor

Bentley²,

Conroy³

et al. 2002

Radiation Protection Dosimetry

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A recent EC directive has called for all member states to introduce legislation covering the assessment and restriction of air crew exposure to cosmic radiation. In the UK the Civil Aviation Authority, in conjunction with the Department of the Environment. Transport and the Regions issued guidelines suggesting the use of a predictive code such as CARI for this purpose. In order to validate the use of calculated route doses, an extensive programme of measurements is being carried out on long haul routes in conjunction with Virgin Atlantic Airways, using a prototype HAWK TEPC developed by Far West Technology. This programme began in January 2000 and by the end of February 2001 had resulted in the accumulation of data from 74 flights. In this paper the instrument design is discussed, together with the calibration programme. An overview of the in-flight results is also presented, including comparisons between measurements and calculations, which indicates that CARI under-predicts the route doses by approximately 20%.

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The Use of TEPC for Reference Dosimetry

Cited by 23 publications

References 0 publications

Linking Microdosimetric Measurements to Biological Effectiveness in Ion Beam Therapy: A Review of Theoretical Aspects of MKM and Other Models

Linking Microdosimetric Measurements to Biological Effectiveness in Ion Beam Therapy: A Review of Theoretical Aspects of MKM and Other Models

Ground-based evaluation of dosimeters for NASA high-altitude balloon flight

The Evaluation and Use of a Portable TEPC System for Measuring In-flight Exposure to Cosmic Radiation

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