The Use of Technetium-99m Pertechnetate in Postoperative Thyroid Carcinoma A Comparative Study with lodine-131

Nf, Khammash; Rk, Halkar; Hm, Abdel-Dayem

doi:10.1097/00003072-198801000-00005

Cited by 16 publications

(6 citation statements)

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“…Our results showed similarities with some previously reported studies [18,22]. Kueh et al [18] retrospectively reviewed seventy post total thyroidectomy patients who had done pre-ablative pertechnetate scan without SPECT/ CT for detection of post-surgical thyroid remnant.…”

Section: Per-lesion Analysissupporting

confidence: 90%

“…Khammash et al [22] studied the usefulness of pertechnetate WBS without SPECT/CT for detecting residual thyroid remnant and functioning metastasis in post-surgical DTC patients. The sensitivity, specificity and accuracy are In contrast to the study of Campbell et al [19] that used pertechnetate WBS without SPECT/CT for detecting DTC metastasis, pertechnetate WBS could detect only 3 foci out of a total of 33 131 I uptake foci.…”

Section: Per-lesion Analysismentioning

confidence: 99%

“…The advantages of pertechnetate over 123 I are widely available, inexpensive with long enough half-life and easiness to prepare. There are some literatures demonstrating the roles of 99m Tc-pertechnetate in the detection of post-thyroidectomy remnant and/or metastasis [18][19][20][21][22]. From a previous study, the main problems of 99m Tc-pertechnetate are its low specificity, possibly due to lack of anatomical localization outside thyroid bed, and low negative predictive value [18].…”

Section: Introductionmentioning

confidence: 99%

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Usefulness of 99mTc-pertechnetate whole body scan with neck and chest SPECT/CT for detection of post-surgical thyroid remnant and metastasis in differentiated thyroid cancer patients

Chantadisai

Kingpetch

2014

Ann Nucl Med

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Pre-ablative pertechnetate WBS with neck and chest SPECT/CT has good correlation for the detection of post-surgical thyroid remnant, cervical node and discrete lung nodule metastasis as compared to (131)I WBS with SPECT/CT per-patient basis. Because (131)I therapeutic activity is desired base on metastatic site and less concerning about the number of lesions, pre-ablative (99m)Tc-pertechnetate WBS with SPECT/CT was a good alternative tool to avoid radioiodine stunning in post-surgical DTC patients.

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Section: Per-lesion Analysissupporting

confidence: 90%

Section: Per-lesion Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Usefulness of 99mTc-pertechnetate whole body scan with neck and chest SPECT/CT for detection of post-surgical thyroid remnant and metastasis in differentiated thyroid cancer patients

Chantadisai

Kingpetch

2014

Ann Nucl Med

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“…Other studies have also revealed that postoperative 99m Tc-pertechnetate scan has a high positive predictive value to detect remnant tissue in DTC patients in the literature. [ 19 , 21 , 29 – 31 ] Their studies were limited to scan of the thyroid bed, so no comments can be made about the value of 99m Tc-pertechnetate scan in detecting extrathyroidal or metastatic sites. Additionally, a low sensitivity of 99m Tc-pertechnetate scan compared with diagnostic 131 I WBS in detecting extrathyroidal and metastatic disease was report in 1990 with an obvious limitation of very small sample size as 5.…”

Section: Discussionmentioning

confidence: 99%

“…[ 15 – 18 ] However, only 3 comparative studies with 131 I can be retrieved, mainly focusing on the diagnostic efficiency of 99m Tc-pertechnetate scan for thyroid remnant. [ 19 – 21 ] To date, the value of 99m Tc-pertechnetate scan (planar scan combined with SPECT/CT [single photon emission computed tomography/computed tomography]) in the management of DTC patients has not been adequately assessed. The relationship between the therapeutic response to 131 I and the avidity of metastatic lesions for 99m Tc-pertechnetate is still unknown.…”

Section: Introductionmentioning

confidence: 99%

99mTc-pertechnetate-avid metastases from differentiated thyroid cancer are prone to benefit from 131I therapy

et al. 2017

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The aim of this study is to determine the contribution of neck and chest 99mTc-pertechnetate scan to the management of postoperative patients with suspicious metastatic differentiated thyroid cancer (DTC), particularly to the prediction of response to radioiodine (131I) therapy. Just before 131I administration, a total of 184 postoperative DTC patients with stimulated serum thyroglobulin (ssTg) >10 ng/mL were enrolled to undergo neck and chest 99mTc-pertechnetate scan, which were directly compared with post-therapeutic 131I scan to determine the concordance of site and number of metastatic lesions. The percentage changes in ssTg between 99mTc-pertechnetate-avid group and 99mTc-pertechnetate-nonavid group were compared, and the response to 131I in both groups was analyzed according to the nature of 99mTc-pertechnetate avidity as well. The percentages of concordance between 99mTc-pertechnetate and 131I scan in detecting metastases were 65.7% and 26.0% in per-patient and per-site analyses with low unweighted kappa, respectively. 99mTc-pertechnetate scan led to a change in therapeutic decision making in 19/184 (10.3%) patients. In 72 patients with 131I-avid metastases, the ssTg in 99mTc-pertechnetate-avid group (n = 13) decreased significantly compared with that in 99mTc-pertechnetate-nonavid group (n = 59) (median: −81.56% vs −48.14%; Z = −4.276, P = .000). The difference of therapeutic response between 99mTc-pertechnetate-avid group and 99mTc-pertechnetate-nonavid group was statistically significant (χ2 = 8.4; P = .03). Although the consistency between 99mTc-pertechnetate scan before 131I administration and post-therapy 131I scan in detecting metastases is low, identifying metastases in postoperative DTC patients with elevated ssTg via 99mTc-pertechnetate scan prior to 131I therapy provides incremental value for therapeutic decision making. Notably, patients with 99mTc-pertechnetate-avid metastases may be more prone to benefit from 131I therapy than those with 99mTc-pertechnetate-nonavid metastases.

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The Role of Nuclear Medicine

Grewal

Larson

Carrasquillo

2010

A Practical Manual of Thyroid and Parathyroid Disease

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The Use of Technetium-99m Pertechnetate in Postoperative Thyroid Carcinoma A Comparative Study with lodine-131

Cited by 16 publications

References 0 publications

Usefulness of 99mTc-pertechnetate whole body scan with neck and chest SPECT/CT for detection of post-surgical thyroid remnant and metastasis in differentiated thyroid cancer patients

Usefulness of 99mTc-pertechnetate whole body scan with neck and chest SPECT/CT for detection of post-surgical thyroid remnant and metastasis in differentiated thyroid cancer patients

99mTc-pertechnetate-avid metastases from differentiated thyroid cancer are prone to benefit from 131I therapy

The Role of Nuclear Medicine

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