The use of tapered plastic luer connectors in neonatal extracorporeal membrane oxygenation

McElwee, Dorothy; Snyder, Ed

doi:10.1016/s0147-9563(96)80069-0

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…Flexible tubing in ECMO and ventricular assist device (VAD) circuits 22 Silicone Pacemaker leads, peristaltic tubing, catheters 25 Dacron Vascular grafts 26 PTFE Vascular grafts 26 PTFE, polytetrafluoroethylene; PVC, polyvinyl chloride.…”

Section: Pvcmentioning

confidence: 99%

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Thrombogenicity of biomaterials depends on hemodynamic shear rate

et al. 2021

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Background: While it is well recognized that different biomaterials induce thrombosis at low shear rates, the effect of high shear rates may be quite different. We hypothesize that the amount of thrombus formation on a given material can be greatly influenced by the local shear rate.Methods: We tested this hypothesis with two different whole blood perfusion loop assays to quantify biomaterial thrombogenicity as a function of shear stress.One assay uses obstructive posts (pins) of material positioned centrally in a tube perfused at high shear rate of >5000/s for 24 h. A second assay uses a parallel plate chamber to perfuse low (<150/s), medium (~500/s), and high shear rates over 96 h. We evaluated the thrombogenicity of seven different biomaterials including stainless steel, acrylic, ceramic, Dacron, polytetrafluoroethylene (PTFE), silicone, and polyvinyl chloride (PVC).Results: For the pin assay, thrombus mass was significantly greater for stainless steel than either zirconia ceramic or acrylic (p < 0.001). Similarly, the parallel plate chamber at high shear showed that steel and PTFE (p < 0.02) occluded the chamber faster than acrylic. In contrast, a low shear parallel plate chamber revealed that stainless steel and PTFE were least thrombogenic, while silicone, Dacron, and other plastics such as acrylic were most thrombogenic. Histology revealed that high shear thrombi had a large proportion of platelets not seen in the low shear fibrin-rich thrombi. Conclusion:This differential thrombogenicity based on shear rate conditions may be important in the selection of biomaterials for blood-contacting devices.

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Section: Pvcmentioning

confidence: 99%

“…Extracorporeal membrane oxygenation (ECMO) connectors 22 Zirconia ceramic Ball heads for total hip replacement, 23 potential use as bearing pin in centrifugal pumps 24…”

Section: Acrylicmentioning

confidence: 99%