The use of systemic tetracyclines and ultraviolet in cancer detection

Daily Growth in Length of Diaphysis Measured by Oxytetracycline in Rabbit Normally

“…Degenerating and necrotising tissues, undergoing calcification bind large amounts of tetracyclines (Hakkinen 1959, Vassar et al 1960, Mustakallio 1962. The tetracyclines are also bound to a varying extent to certain types of tumours, presumably to the proteins of the tumour cells , McLeay 1958, Milch et al 1961, Yabe et al 1964 or to calcium salts in and around the tumour (Vassar et al 1960, Malek and Kolc 1960, Owen 1961 or in association with resorption of necrotic areas (Vassar et al 1960, Mustakallio 1962.…”

Clinical pharmacology of the tetracycline antibiotics

“…They postulated that binding to metallic cations had occurred in bone, since the fluorescent material could be removed by ethylenediaminetetracetic acid at pH 7.3. These observations have been extended by Rail and co-work-ers69 and by McLeay, 70 who reported that CTC, OTC, and TC each appeared in a number of experimental tumors of mice and rats as well as in human tumors. The fluorescence persisted for at least 10 to 20 days in tumor and bone, but not in other tissues.…”

Delineating melanoma using multimodal polarized light imaging

“…Exogenous chromophores and fluorophores are often used for enhancing the contrast of the lesions. For example, TCN is a highly fluorescent antibiotic that has high affinity to cancer cells and has been used in multiple trials as an aid for diagnosing cancer [7][8][9][10][11]. MB, which is FDA approved for in vivo use, has been successfully applied to demarcate non-melanoma skin cancers [2,3], tumors of bladder [12][13][14], pancreas [15], Barrett's esophagus metaplasia [16,17], tracking melanoma metastases in lymph nodes [18], and identification of breast cancer metastasis [19].…”