2011
DOI: 10.5640/insc.0103136
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The Use of Stem Cells in the Treatment of Parkinsons Disease

Abstract: Abstract:Parkinson's disease (PD) is a degenerative neurological disorder characterized by the cardinal motor features of tremor, bradykinesia and rigidity. It is associated with the extended loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) resulting in a severe deficiency of DA in the striatum required for motor control. There is currently no cure for PD and the majority of treatments available aim to reverse dopamine deficiency and the relief of the symptoms. Based on promising f… Show more

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Cited by 5 publications
(4 citation statements)
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References 116 publications
(125 reference statements)
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“…But these compounds varied with success [128]. In addition to these strategies, stem cell therapies may serve as potential treatments for neurodegenerative disease [129,130]. In light of the review, it discussed the possibility that stem cells may be used in the treatment of MS [131].…”
Section: Discussionmentioning
confidence: 99%
“…But these compounds varied with success [128]. In addition to these strategies, stem cell therapies may serve as potential treatments for neurodegenerative disease [129,130]. In light of the review, it discussed the possibility that stem cells may be used in the treatment of MS [131].…”
Section: Discussionmentioning
confidence: 99%
“…PD is the second most common neurodegenerative disease of the aging central nervous system after Alzheimer dementia [ 16 ]. Stem cell-based therapies aim to provide a long-lasting symptomatic relief for PD patients.…”
Section: Discussionmentioning
confidence: 99%
“…They provide multiple support mechanisms such as anti-in fl ammatory, angiogenic and neurogenic capacity, and suf fi cient neuroprotective in fl uence that enhance the survival of the endogenous neurons as well as the exogenous transplanted cells [ 52,53 ] . NSCs could be obtained from the mouse embryo around the embryonic day (E)14-E15 and from human embryo at the 13th week [ 54 ] . These neural stem cells are so bene fi cial as they retain the multipotency pattern that gives them the ability to produce the three major cell lineages of the central nervous system: the neurons, oligodendrocytes, and astrocytes.…”
Section: Adult Nscsmentioning
confidence: 99%