The use of standardized uptake values for assessing FDG uptake with PET in oncology: a clinical perspective

Lucignani, Giovanni; Paganelli, Giovanni; Bombardieri, Emilio

doi:10.1097/01.mnm.0000134329.30912.49

Cited by 125 publications

(77 citation statements)

References 24 publications

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“…Standardized uptake values (SUV; ref. 28) were derived from decay-corrected time activity curves (at midframe time periods for each frame) and normalized for injected activity and body surface area (body surface area = 0.20247 × height (m) 0.725 × weight (kg) 0.425 ; University of Wisconsin). 6 Specifically, we derived…”

Section: Methodsmentioning

confidence: 99%

[11C]Choline Positron Emission Tomography in Estrogen Receptor–Positive Breast Cancer

Contractor

Kenny

Stebbing

et al. 2009

Clinical Cancer Research

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Purpose: Novel radiotracers could potentially allow the identification of clinically aggressive tumor phenotypes. As choline metabolism increases during malignant transformation and progression of human mammary epithelial cells, we examined the ability of [11 C]choline (CHO) positron emission tomography imaging to detect clinically aggressive phenotype in patients with estrogen receptor (ER)-positive breast cancer in vivo. Experimental Design: CHO positron emission tomography was done in 32 individuals with primary or metastatic ER-positive breast cancer. Semiquantitative (standardized uptake value) and fully quantitative (net irreversible transfer rate constant of CHO, Ki) estimates of CHO uptake in the tumors were calculated and compared with tumor grade, size, involved nodes, and also ER, progesterone receptor, Ki-67, and human epidermal growth factor receptor-2 scores. Results: Breast tumors were well visualized in 30 of 32 patients with good tumor background ratios. A wide range of uptake values were observed in primary and metastatic tumors. CHO uptake variables correlated well with tumor grade. For most imaging variables, a poor association was found with tumor size, ER, progesterone receptor, human epidermal growth factor receptor-2, Ki-67, and nodal status. Conclusions: CHO showed good uptake in most breast cancers and merits further investigation as a breast cancer imaging agent. (Clin Cancer Res 2009;15(17):5503-10) Breast cancer is the commonest female malignancy with >1.2 million women diagnosed each year worldwide. Over 75% of breast carcinomas express estrogen receptor (ER). Hence, ERpositive breast cancer is usually treated with antiestrogens, such as tamoxifen. Adjuvant hormonal treatment with tamoxifen followed by an aromatase inhibitor for a total of 5 years (1), as well as aromatase inhibitors alone (2), have been shown to improve recurrence-free survival and overall survival. However, patients relapse despite adjuvant hormonal therapy, due to drug resistance. Only approximately half of the patients with recurrence in ER-positive disease respond to endocrine therapy, whereas the remainder show resistance, clinically evidenced by progression (3). The mechanisms underlying this process are complex, but it is generally agreed that, at least in some patients, cross-talk between cell surface receptor kinases and ER may play a role. In this regard, phosphorylation of ERα by the mitogen-activated protein kinase (MAPK; refs. 4-7) and phosphatidylinositol-3-kinase pathways (3) have been implicated. In particular, MAPK-mediated hyperphosphorylation of ERα on S118, S104, and S106 collectively leads to ligandindependent receptor activation, thereby potentially contributing to resistance to antiendocrine agents, such as tamoxifen and aromatase inhibitors (4,8,9). A large proportion of breast cancers have elevated MAPK (10), and expression correlates to poor response to endocrine therapies (11). There is an unmet need to develop imaging methods to guide clinicians as to the correct choice of su...

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Section: Methodsmentioning

confidence: 99%

[11C]Choline Positron Emission Tomography in Estrogen Receptor–Positive Breast Cancer

Contractor

Kenny

Stebbing

et al. 2009

Clinical Cancer Research

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“…2. In (a) six points are chosen on a PET slice: two points within the normal tissue (1 and 2), two points within the tumor (3 and 4), one point at the boundary of the tumor (5) and one point within the bladder (6). In (b) the TACs of the selected points resulting from a dynamic PET scan are shown.…”

Section: Introductionmentioning

confidence: 99%

“…The most commonly used unit is called SUV (Standardized Uptake Value) which is defined as the ratio of the tissue radioactivity concentration over the injected activity divided by the body weight [6]. It aims to be a quantitative measure of tracer uptake that can be compared between patients, but it is also criticized for its misuse [7].…”

Section: Introductionmentioning

confidence: 99%

Automatic method for tumor segmentation from 3-points dynamic PET acquisitions

Verdoja

Grangetto

Bracco

et al. 2014

2014 IEEE International Conference on Image Processing (ICIP)

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In this paper a novel technique to segment tumor voxels in dynamic positron emission tomography (PET) scans is proposed. An innovative anomaly detection tool tailored for 3-points dynamic PET scans is designed. The algorithm allows the identification of tumoral cells in dynamic FDG-PET scans thanks to their peculiar anaerobic metabolism experienced over time. The proposed tool is preliminarily tested on a small dataset showing promising performance as compared to the state of the art in terms of both accuracy and classification errors.

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“…The most commonly used unit in FDG-PET is called Standardized Uptake Value (SUV) which is defined as [6]:…”

Section: Introductionmentioning

confidence: 99%

Global and local anomaly detectors for tumor segmentation in dynamic pet acquisitions

Verdoja

Bonafè

Cavagnino

et al. 2016

2016 IEEE International Conference on Image Processing (ICIP)

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In this paper we explore the application of anomaly detection techniques to tumor voxels segmentation. The developed algorithms work on 3-points dynamic FDG-PET acquisitions and leverage on the peculiar anaerobic metabolism that cancer cells experience over time. A few different global or local anomaly detectors are discussed, together with an investigation over two different algorithms for estimation of the statistical distribution of normal tissues. Finally, all the proposed algorithm are tested on a dataset composed of 9 patients proving that anomaly detectors are able outperform techniques in the state of the art.

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The use of standardized uptake values for assessing FDG uptake with PET in oncology: a clinical perspective

Cited by 125 publications

References 24 publications

[11C]Choline Positron Emission Tomography in Estrogen Receptor–Positive Breast Cancer

[11C]Choline Positron Emission Tomography in Estrogen Receptor–Positive Breast Cancer

Automatic method for tumor segmentation from 3-points dynamic PET acquisitions

Global and local anomaly detectors for tumor segmentation in dynamic pet acquisitions

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