The Use of Split-Thickness Skin Grafts on Diabetic Foot Ulcerations: A Literature Review

McCartan, Brant L.; Dinh, Thanh

doi:10.1155/2012/715273

Cited by 21 publications

(13 citation statements)

References 32 publications

(43 reference statements)

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“…Skin grafting is used to treat severe DFUs that do not improve with the application of wound dressings [ 82 ]. There are various types of skin grafting employed in chronic wound treatment.…”

Section: Treatment Of Diabetic Ulcer/foot Ulcermentioning

confidence: 99%

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

et al. 2020

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Diabetes mellitus (DM) is a chronic metabolic disease with increasing prevalence worldwide. Diabetic foot ulcers (DFUs) are a serious complication of DM. It is estimated that 15–25% of DM patients develop DFU at least once in their lifetime. The lack of effective wound dressings and targeted therapy for DFUs often results in prolonged hospitalization and amputations. As the incidence of DM is projected to rise, the demand for specialized DFU wound management will continue to increase. Hence, it is of great interest to improve and develop effective DFU-specific wound dressings and therapies. In the last decade, 3D bioprinting technology has made a great contribution to the healthcare sector, with the development of personalized prosthetics, implants, and bioengineered tissues. In this review, we discuss the challenges faced in DFU wound management and how 3D bioprinting technology can be applied to advance current treatment methods, such as biomanufacturing of composite 3D human skin substitutes for skin grafting and the development of DFU-appropriate wound dressings. Future co-development of 3D bioprinting technologies with novel treatment approaches to mitigate DFU-specific pathophysiological challenges will be key to limiting the healthcare burden associated with the increasing prevalence of DM.

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Section: Treatment Of Diabetic Ulcer/foot Ulcermentioning

confidence: 99%

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

et al. 2020

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“…Small incisions are made to perforate the STSG to facilitate the evacuation of blood exudate without compromising graft integrity. The combination of an STSG and dermal skin substitutes can help improve the quality, elasticity, pliability of reconstructed tissue and the aesthetic results (McCartan and Dinh, 2012;Wain et al, 2012).…”

Section: Split-thickness Skin Graftsmentioning

confidence: 99%

Textbook of Plastic and Reconstructive Surgery

Butler¹,

Ghali²,

Kalaskar³

2016

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A CIP catalogue record for this book is available from The British Library.This book is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. The user is advised to always check the product information and clinical procedures with the most up-to-date published product information and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or misuse or misapplication of material in this work.ISBN: 978-1-910634-37-0 (Hbk.) ISBN: 978-1-910634-38-7 (Pbk.) ISBN: 978-1-910634-39-4 (PDF) ISBN: 978-1-910634-40-0 (epub) ISBN: 978-1-910634-41-7 (mobi)

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“…Current therapeutic protocols are based on debridement and application of skin grafts to protect the exposed layers and to allow reconstitution of the damaged portion. Autologous grafting allows full integration into the donor site; however, this approach is limited by the amount of skin available for wound coverage and rapid re-epithelialization as well as the creation of additional deficits, especially in cases with severe burns and skin morbidities [2,3]. Allogeneic and xenogeneic skin grafts are also employed due to their better availability and accessibility of material for wound closure.…”

Section: Introductionmentioning

confidence: 99%

Long-term expansion of directly reprogrammed keratinocyte-like cells and in vitro reconstitution of human skin

et al. 2020

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Background: Human keratinocytes and derived products are crucial for skin repair and regeneration. Despite substantial advances in engineered skin equivalents, their poor availability and immunorejection remain major challenges in skin grafting. Methods: Induced keratinocyte-like cells (iKCs) were directly reprogrammed from human urine cells by retroviral transduction of two lineage-specific transcription factors BMI1 and △NP63α (BN). Expression of keratinocyte stem cell or their differentiation markers were assessed by PCR, immunofluorescence and RNA-Sequencing. Regeneration capacity of iKCs were assessed by reconstitution of a human skin equivalent under air-interface condition. Results: BN-driven iKCs were similar to primary keratinocytes (pKCs) in terms of their morphology, protein expression, differentiation potential, and global gene expression. Moreover, BN-iKCs self-assembled to form stratified skin equivalents in vitro. Conclusions: This study demonstrated an approach to generate human iKCs that could be directly reprogrammed from human somatic cells and extensively expanded in serum-and feeder cell-free systems, which will facilitate their broad applicability in an efficient and patient-specific manner.

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The Use of Split-Thickness Skin Grafts on Diabetic Foot Ulcerations: A Literature Review

Cited by 21 publications

References 32 publications

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

Textbook of Plastic and Reconstructive Surgery

Long-term expansion of directly reprogrammed keratinocyte-like cells and in vitro reconstitution of human skin

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