The use of sintered bone in spinal surgery

Minamide, Akihito; Tamaki, Toru; Yoshida, Munehito; Hashizume, Hiroshi; Nakagawa, Yukihiro

doi:10.1007/s005860100274

Cited by 9 publications

(9 citation statements)

References 12 publications

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“…Deproteinized bovine bone has been successfully used as a graft material for GBR Slotte & Lundgren 1999). Sintered bone, which is one type of deproteinized bone graft material, is a natural biomaterial derived from the calcium phosphate system (Minamide et al 2001). This bone graft material was in close contact with newly formed bone, and integrated with recipient bone or newly formed bone without inflammatory reaction.…”

Section: Discussionmentioning

confidence: 99%

Blood‐filled spaces with and without deproteinized bone grafts in guided bone regeneration

Okazaki

Shimizu

et al. 2004

Clinical Oral Implants Res

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This experimental study evaluated the effects of deproteinized bone grafts on guided bone regeneration (GBR). A groove was made in the bone marrow of the external cortical plate of the skull. A dome of non-resorbable membrane was placed on the groove and secured with titanium pins. The secluded graft space was filled with autogenous blood clots (control group) and deproteinized bone particles (experimental group). The rabbits were sacrificed 2, 4, 8 and 12 weeks after the operation. Decalcified and paraffin-embedded, transverse 3-mum-thick sections were made and stained with hematoxylin and eosin. The proportions of newly formed bone and newly formed bone-graft particle contact surfaces were histomorphometrically measured in the basal, central, and peripheral areas from the cortical plate to the top of the dome. In the control group, the basal area showed a significant increase at 4 weeks (P<0.01) and a significant decrease at 8 weeks (P<0.01). The central and peripheral areas showed gradual increases in the proportion of newly formed bone. The experimental group showed significant increase at 4 weeks in the basal area and at 8 weeks in central and peripheral area (P<0.01). There were significant differences between both groups in basal and central area (P<0.01). The proportion of newly formed bone-graft particle contact length showed significant increases at 4 weeks (P<0.01) and no significant decreases at 8 and 12 weeks in three areas. The present study showed that deproteinized bone grafts maintain newly formed bone in extensive areas for a prolonged period during GBR.

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Section: Discussionmentioning

confidence: 99%

Blood‐filled spaces with and without deproteinized bone grafts in guided bone regeneration

Okazaki

Shimizu

et al. 2004

Clinical Oral Implants Res

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“…To realize an effective application in bone tissue engineering, it is preferable to develop a bone graft biomaterial that can serve as not only a factor delivery vehicle but also a three-dimensional porous scaffold. In the present study, TBC was selected for its excellent osteoconductive capacity and biocompatibility, dependent on the inherent trabecular structure with an organized crystal of bone minerals. , With incorporation of nHA coating and chitosan on the TBC surface, few impacts were observed on the macrostructure. CH/TBC remained a constant three-dimensional porous structure with optimum pore size for bone ingrowth at a range of 100–800 μm .…”

Section: Resultsmentioning

confidence: 99%

“…Thus, we have developed a desired delivery scaffold by coating TBC substrates with nanohydroxyapatite (nHA) and chitosan (CS). TBC was selected for its inherent natural trabecular structure with an organized crystal of bone minerals, which was considered highly biomimetic and able to facilitate the growth of vessels into the material to provide a suitable environment for bone regeneration. , Considering the high affinity of PTHdP to apatite, nHA coating and chitosan were further applied on the TBC surface to improve the bioactivity and peptide immobilization capability. , The biological effects of PTHdP released from the composite scaffolds were examined both in vitro and in vivo to determine a promising alternative strategy for future bone tissue engineering.…”

Section: Introductionmentioning

confidence: 99%

Bone Regeneration Induced by Local Delivery of a Modified PTH-Derived Peptide from Nanohydroxyapatite/Chitosan Coated True Bone Ceramics

Yang

Huang

Yang

et al. 2018

ACS Biomater. Sci. Eng.

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A novel PTH-derived peptide, PTHdP, including a repetitive aspartic acid sequence at the C-terminal and phosphorylated serine at the N-terminal has been previously designed. To evaluate its potential as a bone growth factor for bone tissue engineering, true bone ceramics incorporated with nanohydroxyapatite coating and chitosan (CH/TBC) was developed as a desired three-dimensional porous delivery carrier in this study. In vitro results showed that PTHdP could be loaded with high-efficiency and subsequently released in a controlled and sustained manner from CH/TBC. Bioactivity of released PTHdP was retained and able to exert a significant effect on promoting or inhibiting osteogenesis actions when exposed intermittently or continuously, respectively, for MC3T3-E1 cell culture. As evaluated in a critical-size rabbit radial defect model by radiographic and histological examination, the combination of CH/TBC scaffolds with PTHdP exhibited a remarkably stronger capacity to stimulate new bone formation than control and pure CH/TBC groups. These results indicated the novel PTHdP peptide achieved high affinity to bone mineral without interference in bioactivity, and local delivery of PTHdP from apatite materials could be a promising alternative for future bone tissue engineering.

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“…1,2 In an in vitro study, TBC was shown to promote the proliferation and differentiation of osteoblasts. 3 Minamide et al 4 showed that in a pig model, the implantation of TBC effectively promoted healing in spinal fusion procedures. The authors noted that the implant ''adjusted'' to the stiffness of the host recipient bone, a property that was considered particularly important in spinal surgery as implants that are more rigid could cause stress shielding and lead to osteopenia.…”

Section: Introductionmentioning

confidence: 99%

“…This may not necessarily be a disadvantage, as the strength of the sintered material may more closely reflect that of the recipient bone of the intended implant region, for example in the case of osteoporotic bone. 4 Conversely, for applications where greater strength is required, the infiltration of SCBB with a Correspondence to: M. R. Mucalo; e-mail: m.mucalo@waikato.ac.nz Contract grant sponsors: WaikatoLink Ltd (biocompatibility testing which was conducted at the University of Otago, Dunedin, New Zealand) biocompatible and bioresorbable reinforcing material could greatly improve mechanical performance.…”

Section: Introductionmentioning

confidence: 99%

Vacuum‐assisted infiltration of chitosan or polycaprolactone as a structural reinforcement for sintered cancellous bovine bone graft

Laird

Mucalo

Dias

2012

J Biomedical Materials Res

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Sintered cancellous bovine bone (SCBB) offers numerous advantages as a bone graft substitute material; however, its mechanical properties require improvement. In this study, SCBB was infiltrated with ε-polycaprolactone (PCL) or chitosan/monetite to improve mechanical properties while retaining valuable SCBB structure. Organic infiltrating solutions consisted of (i) chitosan and monetite (CaHPO(4)) dissolved in hydrochloric acid; (ii) chitosan, monetite (CaHPO(4)), and genipin dissolved in hydrochloric acid; or (iii) PCL polymer dissolved in tetrahydrofuran (THF). Porous SCBB materials were infiltrated with one of the three solutions using vacuum-assisted infiltration. Chitosan and CaHPO(4) were immobilized in the SCBB structure by reprecipitation following a pH increase in an ammonia atmosphere. Genipin was used in one sample group to immobilize chitosan via crosslinking. PCL was immobilized by evaporating the THF carrier solvent. Mechanical compression testing showed an improvement in ultimate stress for the SCBB with chitosan/CaHPO(4) infiltrates, whereas PCL samples showed an increase in modulus. All SCBB samples were found to demonstrate favorable in vitro biocompatibility when subjected to L929 mouse fibroblast cells but required a vigorous washing regime to eradicate toxic ammonia residue. In conclusion, infiltration of SCBB with a polymeric or organic/mineral composite matrix positively modifies SCBB mechanical properties in favor of bone grafting applications.

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The use of sintered bone in spinal surgery

Cited by 9 publications

References 12 publications

Blood‐filled spaces with and without deproteinized bone grafts in guided bone regeneration

Blood‐filled spaces with and without deproteinized bone grafts in guided bone regeneration

Bone Regeneration Induced by Local Delivery of a Modified PTH-Derived Peptide from Nanohydroxyapatite/Chitosan Coated True Bone Ceramics

Vacuum‐assisted infiltration of chitosan or polycaprolactone as a structural reinforcement for sintered cancellous bovine bone graft

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