1978
DOI: 10.1016/0027-5107(78)90234-8
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The use of short-term tests to measure the preventive action of reducing agents on formation and activation of carcinogenic nitroso compounds

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1979
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Cited by 22 publications
(3 citation statements)
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“…While its antioxidant properties are well known worldwide, its use as an effective anticancer substance is highly controversial (13). For instance, ascorbic acid has been reported to exhibit anti-carcinogenic and antimutagenic activities (14,15); however, its adverse effects have also been well documented (16,17). …”
Section: Introductionmentioning
confidence: 99%
“…While its antioxidant properties are well known worldwide, its use as an effective anticancer substance is highly controversial (13). For instance, ascorbic acid has been reported to exhibit anti-carcinogenic and antimutagenic activities (14,15); however, its adverse effects have also been well documented (16,17). …”
Section: Introductionmentioning
confidence: 99%
“…of DNA fragmentation or DNA repair , 1977cLo and Stich, 1978) by carcinogens do not reveal whether these DNA lesions will be actually translated into mutations. On the other hand, the use of mutations of bacteria and yeast as an endpoint could easily lead to an over or under estimation of the actual carcinogenic activity of a compound for man.…”
Section: New Prioritiesmentioning
confidence: 99%
“…A few promising exploratory attempts along this line have already been made. We have successfully applied human cells as subjects and DNA repair synthesis as the endpoint to reveal the preventive action of several reducing agents (Lo and Stich, 1978). Moreover, Salmonella typhirnurileraz treated with carcinogens and reducing agents, anti-oxidants or selenium, readily reveals the antimutagenic effect of these compounds (Rosin and Stich, 1978a,b;Jacobs et al , 1977).…”
Section: New Prioritiesmentioning
confidence: 99%