The Use of Serum Protein Electrophoresis in Clinical Medicine

Wall, Robert L.

doi:10.1001/archinte.1958.00260210104015

Cited by 52 publications

(6 citation statements)

References 176 publications

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“…However, hypergammaglobulinemia of the IgG and IgM type was present. Abnormalities of the immunoglobulin system are not uncommon in acute granulocytic leukemia (29, 31) and in diseases characterized by autoimmune phenomena (1). Most auto‐antibodies are best considered as secondary immunological sequelae to tissue damage from a variety of stimuli, rather than the primary causal defect (15).…”

Section: Discussionmentioning

confidence: 99%

Granulocytic Leukemia Associated with Myxedema Thyroiditis and Myasthenia Gravis

Sparagana

Grieble

Rubinstein

1972

Journal of the American Geriatrics Society

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A case of myxedema associated with Hashimoto's thyroiditis, myasthenia gravis, and granulocytic leukemia is described. The patient had the classical symptoms and signs of hypothyroidism. Profound myopathy, ptosis, and bulbar signs suggested myasthenia gravis and the diagnosis was confirmed by an anticholinesterase test. Treatment with cholinesterase inhibitors was ineffective and ACTH was given for increasing bulbar signs and ventilatory failure. Severe pneumonia supervened and was thought t o be the cause of a striking leukemoid blood picture. However, the leukemoid picture persisted after the pneumonia cleared. While convalescing, the patient died suddenly. At autopsy, granulocytic infiltrates of several organs and a hypercellular bone marrow with a preponderance of granulocytes, a decrease in erythrocytic elements and virtual absence of megakaryocytes were consistent with a diagnosis of granulocytic leukemia. The thyroid disease and the myasthenia gravis may have had an immunological basis and this may also have played a role in the development of the granulocytic leukemia.The association of myasthenia gravis, thyroid disease and certain other auto-immune disorders is well known. This report describes a patient who demonstrated the myxedema of Hashimo to's thyroiditis, myasthenia gravis and granulocytic leukemia. CASE REPORTN.D. was a 50-year-old married white male machinist. He was admitted to Hines Veterans

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Section: Discussionmentioning

confidence: 99%

Granulocytic Leukemia Associated with Myxedema Thyroiditis and Myasthenia Gravis

Sparagana

Grieble

Rubinstein

1972

Journal of the American Geriatrics Society

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“…7). The significance of the dysproteinzmia is not understood ; it could reflect a " stress pattern " (Wall, 1958) but a febrile state and tissue breakdown could be responsible for the changes which cannot be considered to be diagnostically specific in retroperitoneal fibrosis but help only to confirm the presence of organic disease and aid objectively in the evaluation of its course.…”

Section: Discussionmentioning

confidence: 99%

Retroperitoneal Vasculitis With Perivascular Fibrosis

Kay

1963

British Journal of Urology

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SUMMARY A florid case of retroperitoneal fibrosis with severe vascular as well as urinary complications is described. The ætiology is discussed and from a study of the available literature it is concluded that the basic disorder is a vasculitis with similarities to polyarteritis nodosa or the necrotising arteritis of Wegener. Widespread general effects, notably obscure pain, anorexia, and weight loss may precede, by months or years, the more overt ureteric obstructive manifestations: joint symptoms, pericarditis, and respiratory infection may also occur. Obstruction of the inferior vena cava and arterial insufficiency may develop. A raised sedimentation rate is an index of activity. Serum protein changes are non‐specific. Anaemia may be an early manifestation. There is evidence that the connective tissue changes may be widespread and even involve the mediastinum. There is a tendency towards eventual self‐limitation of the disease. Ureterolysis is an efficient method for treatment of the functional obstruction of the ureters and steroid therapy may be of help.

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“…4 indicates 1 or more hospitalizations per year for infections since splenectomy. 5 indicates debilitated or chronically ill. Serum globulin levels were determined with the Spinco Model R Paper Electrophoresis Apparatus with Analytrol Scanner using 0.01 ml. of undiluted serum, stored in a refrigerator for 10 days or less ; Spinco Buffer B-2 and the Model R cell with Duostat Power Supply were used for initial separation.…”

Section: Methodsmentioning

confidence: 99%

Splenectomy and Immunity

Thurman¹

1963

Arch Pediatr Adolesc Med

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The Use of Serum Protein Electrophoresis in Clinical Medicine

Cited by 52 publications

References 176 publications

Granulocytic Leukemia Associated with Myxedema Thyroiditis and Myasthenia Gravis

Granulocytic Leukemia Associated with Myxedema Thyroiditis and Myasthenia Gravis

Retroperitoneal Vasculitis With Perivascular Fibrosis

Splenectomy and Immunity

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