The Use of Second-Generation Antipsychotics and the Changes in Physical Growth in Children and Adolescents with Perinatally Acquired HIV

Kapetanovic, Suad; Aaron, Lisa; Montepiedra, Grace; Sirois, Patricia A.; Oleske, James M.; Malee, Kathleen; Pearson, Deborah A.; Nichols, Sharon L.; Garvie, Patricia A.; Farley, John; Nozyce, Molly; Mintz, Mark; Williams, Paige L.

doi:10.1089/apc.2009.0121

Cited by 4 publications

(3 citation statements)

References 32 publications

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“…An examination of stimulant and non-stimulant medication prescribed for PHIV+ youth found slower rates of growth in height and weight for those on non-stimulant medications [98]. In another study, prescribed second-generation antipsychotic (SGA) medications, in general, and risperidone, specifically, were associated with both short- and long-term changes in body mass index (BMI) Z-scores [99]. Neither of these reports evaluated adherence to the prescribed medications or treatment effects on mental health, yet both point to the need for caution and continued pharmacological studies including assessment of impact.…”

Section: Resultsmentioning

confidence: 99%

Understanding the mental health of youth living with perinatal HIV infection: lessons learned and current challenges

Mellins

Malee

2013

Journal of the International AIDS Society

290

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IntroductionAcross the globe, children born with perinatal HIV infection (PHIV) are reaching adolescence and young adulthood in large numbers. The majority of research has focused on biomedical outcomes yet there is increasing awareness that long-term survivors with PHIV are at high risk for mental health problems, given genetic, biomedical, familial and environmental risk. This article presents a review of the literature on the mental health functioning of perinatally HIV-infected (PHIV+) adolescents, corresponding risk and protective factors, treatment modalities and critical needs for future interventions and research.MethodsAn extensive review of online databases was conducted. Articles including: (1) PHIV+ youth; (2) age 10 and older; (3) mental health outcomes; and (4) mental health treatment were reviewed. Of 93 articles identified, 38 met inclusion criteria, the vast majority from the United States and Europe.ResultsThese studies suggest that PHIV+ youth experience emotional and behavioural problems, including psychiatric disorders, at higher than expected rates, often exceeding those of the general population and other high-risk groups. Yet, the specific role of HIV per se remains unclear, as uninfected youth with HIV exposure or those living in HIV-affected households displayed similar prevalence rates in some studies, higher rates in others and lower rates in still others. Although studies are limited with mixed findings, this review indicates that child-health status, cognitive function, parental health and mental health, stressful life events and neighbourhood disorder have been associated with worse mental health outcomes, while parent–child involvement and communication, and peer, parent and teacher social support have been associated with better function. Few evidence-based interventions exist; CHAMP+, a mental health programme for PHIV+ youth, shows promise across cultures.ConclusionsThis review highlights research limitations that preclude both conclusions and full understanding of aetiology. Conversely, these limitations present opportunities for future research. Many PHIV+ youth experience adequate mental health despite vulnerabilities. However, the focus of research to date highlights the identification of risks rather than positive attributes, which could inform preventive interventions. Development and evaluation of mental health interventions and preventions are urgently needed to optimize mental health, particularly for PHIV+ youth growing up in low-and-middle income countries.

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Section: Resultsmentioning

confidence: 99%

Understanding the mental health of youth living with perinatal HIV infection: lessons learned and current challenges

Mellins

Malee

2013

Journal of the International AIDS Society

290

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“…Among adolescents, a crosssectional study to compare the changes in weight and BMI associ-ated with olanzapine orally disintegrating tablets, olanzapine standard oral tablets or risperidone, reported that those on olanzapine orally disintegrating tablets gained less weight than those on olanzapine standard oral tablets, but not less than those on risperidone [37]. However, among adults, the only randomised clinical trial comparing these two olanzapine formulations found no significant differ-ence [92].…”

Section: Treatment Of Antipsychotic-induced Bmi Increasementioning

confidence: 99%

Weight gain and increase of body mass index among children and adolescents treated with antipsychotics: a critical review

Martínez-Ortega

Funes-Godoy

Díaz-Atienza

et al. 2013

Eur Child Adolesc Psychiatry

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We performed an updated review of the available literature on weight gain and increase of body mass index (BMI) among children and adolescents treated with antipsychotic medications. A PubMed search was conducted specifying the following MeSH terms: (antipsychotic agents) hedged with (weight gain) or (body mass index). We selected 127 reports, including 71 intervention trials, 42 observational studies and 14 literature reviews. Second-generation antipsychotics (SGAs), in comparison with first-generation antipsychotics, are associated with a greater risk for antipsychotic-induced weight gain although this oversimplification should be clarified by distinguishing across different antipsychotic drugs. Among SGAs, olanzapine appears to cause the most significant weight gain, while ziprasidone seems to cause the least. Antipsychotic-induced BMI increase appears to remain regardless of the specific psychotropic co-treatment. Children and adolescents seem to be at a greater risk than adults for antipsychotic-induced weight gain; and the younger the child, the higher the risk. Genetic or environmental factors related to antipsychotic-induced weight gain among children and adolescents are mostly unknown, although certain genetic factors related to serotonin receptors or hormones such as leptin, adiponectin or melanocortin may be involved. Strategies to reduce this antipsychotic side effect include switching to another antipsychotic drug, lowering the dosage or initiating treatment with metformin or topiramate, as well as non-pharmacological interventions. Future research should avoid some methodological limitations such as not accounting for age- and sex-adjusted BMI (zBMI), small sample size, short period of treatment, great heterogeneity of diagnoses and confounding by indication.

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“…Close communication should be maintained between the consulting psychiatrists, pediatricians and/or infectious disease specialists involved in the child's care and nutritional counseling provided. The youth and their caregivers should be educated about the potential for SGA-related TC increase, as well as other complications previously reported in perinatally HIV-infected youth treated with SGAs, such as increased body mass index z -scores 25. Careful risk-benefit analysis should always be included in this process, given the known benefits of SGAs in treatment of certain psychiatric disorders in youth,8 and potential impact of untreated psychotic symptoms on their medical care, safety, and overall quality of life.…”

Section: Discussionmentioning

confidence: 99%

Relationships between the use of second-generation antipsychotics and changes in total cholesterol levels in children and adolescents perinatally infected with HIV

Kapetanovic

Aaron²,

Williams³

et al. 2010

NBHIV

Self Cite

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Purpose Perinatally HIV-infected children, who are increasingly aging into adolescence and early adulthood, have significant rates of psychiatric co-morbidities, some of which are treated with second-generation antipsychotics (SGAs). SGAs have been associated with elevated total cholesterol (TC) in youth, but no studies have examined this association in perinatally HIV-infected youth. This study examined changes in TC levels of youth with perinatally acquired HIV infection and co-morbid psychiatric conditions treated with SGAs. Patients and methods Long-term changes in TC levels were examined using data from the US multisite prospective Pediatric AIDS Clinical Trials Group 219C cohort study. The change in TC levels from baseline to 12 months after initiating SGA use was compared between 52 SGA-exposed and 148 matched SGA-unexposed perinatally HIV-infected youth, using generalized estimating equation models adjusting for other covariates. The prevalence and time to incident hypercholesterolemia were also compared between these 2 groups. Results After adjustment for confounders, 52 youth with prescriptions for SGAs had a larger increase in TC levels than 148 matched youth without antipsychotic prescriptions (mean difference = 9 mg/dL, z = 1.96, df = 1, P = 0.0496). Among youth with TC below 220 mg/dL at baseline, 27% of SGA-exposed youth developed hypercholesterolemia (defined as two consecutive TC measurements ≥220 mg/dL), compared with 13% of SGA-unexposed patients (Fisher's exact test, P = 0.046). Conclusions Caution should be used in prescribing SGAs to perinatally HIV-infected youth with psychiatric co-morbidities due to increased risk of hypercholesterolemia. Patients should be monitored, and alternative evidence-based treatments considered when available.

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The Use of Second-Generation Antipsychotics and the Changes in Physical Growth in Children and Adolescents with Perinatally Acquired HIV

Cited by 4 publications

References 32 publications

Understanding the mental health of youth living with perinatal HIV infection: lessons learned and current challenges

Understanding the mental health of youth living with perinatal HIV infection: lessons learned and current challenges

Weight gain and increase of body mass index among children and adolescents treated with antipsychotics: a critical review

Relationships between the use of second-generation antipsychotics and changes in total cholesterol levels in children and adolescents perinatally infected with HIV

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