The use of scalp hypothermia in the prevention of doxorubicin-induced hair loss

Satterwhite, Barbara Armstrong; Zimm, Solomon

doi:10.1002/1097-0142(19840701)54:1<34::aid-cncr2820540109>3.0.co;2-w

Cited by 47 publications

(67 citation statements)

References 6 publications

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“…Seven randomized clinical studies have been published which examined the effectiveness of scalp cooling [13,16,21,25,30,34,36]. These studies randomized a total of 233 patients.…”

Section: Introductionmentioning

confidence: 69%

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Scalp cooling to prevent chemotherapy-induced hair loss: practical and clinical considerations

Mols

Hurk

Vingerhoets

et al. 2008

Support Care Cancer

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Chemotherapy-induced hair loss is perceived as burdensome. It may be prevented by offering scalp cooling which is often an effective method to prevent this form of hair loss and is tolerated well by patients. However, if possible, scalp-cooling techniques should be improved and their effectiveness should be increased because if scalp cooling is unsuccessful, patients' rate their hair loss as more burdensome compared to noncooled patients.

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“…Seven randomized clinical studies have been published which examined the effectiveness of scalp cooling [13,16,21,25,30,34,36]. These studies randomized a total of 233 patients.…”

Section: Introductionmentioning

confidence: 69%

“…b The number and percentage of questionnaires on which the statements were answered affirmatively. 8,36]. The recent, more intensive, adjuvant chemotherapy treatments in breast cancer may explain the relatively low success percentage of about 50% in this study.…”

Section: The Effectiveness Of Scalp Coolingmentioning

confidence: 91%

Scalp cooling to prevent chemotherapy-induced hair loss: practical and clinical considerations

Mols

Hurk

Vingerhoets

et al. 2008

Support Care Cancer

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“…However, the cooling techniques in a variety of local application forms have been used to prevent or minimize other conditions like alopecia resulting from chemotherapy. [12][13][14] The hypotheses behind the impact of hypothermia for a localized area have included a variety of proposed factors, ranging from decreased metabolic activity of cells in the local area to decreased blood flow resulting in less drug exposure.…”

Section: Discusssionmentioning

confidence: 99%

The impact of cold therapy on the incidence and severity of paclitaxel induced peripheral neuropathy: A pilot study

Younus¹,

Kligman²,

Jawaid

2016

JST

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Background: Peripheral neuropathy is a common side effect induced by chemotherapy agents like Cisplatin, Paclitaxel and Docetaxel. At present, there is no preventive strategy available against the development of neuropathy. This pilot study was performed to evaluate the feasibility of cold therapy and its impact on the incidence and severity of neuropathy induced by paclitaxel in a dose dense adjuvant regimen among patients with breast cancer. Methods: All adult female patients with early breast cancer planned to be treated with dose-dense schedule of Adriamycin, cyclophosphamide and Paclitaxel were eligible. Ice boot and glove were applied for the duration of all four Paclitaxel infusions on one side while the contralateral limbs were taken as control. Peripheral neuropathy was evaluated and graded prior to each Paclitaxel infusion and then at 3 and 6 months post treatment. Results: A total of 23 patients were recruited. Cold therapy was found to be feasible as no patient discontinued the ice glove and boot during Paclitaxel infusions. Neuropathy symptoms were observed more frequently and with higher grade of severity on control limbs compared to experimental side. There were 5 patients who were switched to ice glove and boot therapy after they developed peripheral neuropathy in the control limbs. These patients observed improvement in their symptoms subsequently. Conclusion: Cold therapy appears to be feasible and appears to have some potential to prevent Paclitaxel induced peripheral neuropathy in this pilot study. This role of cold therapy may be further explored and confirmed in future randomized trials.

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“…A comprehensive review, published in 2005, concluded that the majority of findings were positive, with an average success rate prior to and after 1995 of 56% and 73%, respectively (most often based on the World Health Organization [WHO] alopecia grading criteria and less frequently on the need for a wig or a head cover). 60 Six of the seven randomized trials ( N =233) published to date were positive and, of these, five occurred in the 1970s and 1980s, 58, 61-64 whereas only two were more recent. 65, 66 Although the chemotherapy regimens used in these earlier studies differed from more recent studies, other methodological variables including scalp-cooling technique, post-infusion cooling times, duration of chemotherapy infusion, and eligibility criteria make comparisons between studies difficult.…”

Section: Chemotherapy-induced Alopeciamentioning

confidence: 99%

Supportive Cryotherapy: A Review From Head to Toe

Kadakia

Rozell

Butala

et al. 2014

Journal of Pain and Symptom Management

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Context Conventional chemotherapy leads to multiple adverse mucocutaneous complications including oral mucositis, alopecia, ocular toxicity, and onycholysis. Limited pharmacologic interventions are available for preventing these clinical problems. Objectives This study aimed to critically review the role of cryotherapy (regional hypothermia) for alleviating these adverse symptoms. Methods A narrative review was performed, with an emphasis on randomized controlled trials. A comprehensive search using PubMed, Ovid, Embase, and MEDLINE® was completed. References of all cited articles also were reviewed. Data from the review were comprised of articles published between 1970 to May 2013. Results Available evidence suggests that regional hypothermia decreases the burden of chemotherapy-related oral mucositis, alopecia, ocular toxicity, and onycholysis. The major limitations of studies include the absence of blinded control groups and variable clinical endpoints. Conclusion Regional hypothermia decreases the burden of these four chemotherapy-induced complications and is well tolerated. More research is needed to determine what subgroups of cancer patients are most likely to respond to different types of regional hypothermia, the ideal duration of cooling needed, and to further improve the ease of use of the cooling devices.

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The use of scalp hypothermia in the prevention of doxorubicin-induced hair loss

Cited by 47 publications

References 6 publications

Scalp cooling to prevent chemotherapy-induced hair loss: practical and clinical considerations

Scalp cooling to prevent chemotherapy-induced hair loss: practical and clinical considerations

The impact of cold therapy on the incidence and severity of paclitaxel induced peripheral neuropathy: A pilot study

Supportive Cryotherapy: A Review From Head to Toe

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