The Use of Salivary as a Biometric Tool to Determine the Presence of Carcinoma of the Breast Among Women

Streckfus, Charles F.; Guajardo-Edwards, Cynthia

doi:10.5772/17655

Cited by 1 publication

(1 citation statement)

References 13 publications

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“…They are abundant, and fit the profile of other body fluids [ 68 , 69 ], which makes them good BM candidates for systemic diseases. In fact, MiRNAs associated with CRC, esophageal, and pancreatic cancer (PC) were isolated from saliva [ 70 , 71 ], showing that profiling miRNA expression could allow for the detection of a distant neoplasia while discriminating between different cancer types [ 23 , 72 ]. For all these reasons, several current research efforts are focused on the detection of salivary miRNAs, although we need to better understand their biogenesis and how to recognize their tissue of origin [ 73 ].…”

Section: Saliva: An Informative Analyte For Mirna Detection With Prac...mentioning

confidence: 99%

Circulating Biomarkers for Cancer Detection: Could Salivary microRNAs Be an Opportunity for Ovarian Cancer Diagnostics?

2023

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MicroRNAs (miRNAs) are small non-coding RNAs with the crucial regulatory functions of gene expression at post-transcriptional level, detectable in cell and tissue extracts, and body fluids. For their stability in body fluids and accessibility to sampling, circulating miRNAs and changes of their concentration may represent suitable disease biomarkers, with diagnostic and prognostic relevance. A solid literature now describes the profiling of circulating miRNA signatures for several tumor types. Among body fluids, saliva accurately reflects systemic pathophysiological conditions, representing a promising diagnostic resource for the future of low-cost screening procedures for systemic diseases, including cancer. Here, we provide a review of literature about miRNAs as potential disease biomarkers with regard to ovarian cancer (OC), with an excursus about liquid biopsies, and saliva in particular. We also report on salivary miRNAs as biomarkers in oncological conditions other than OC, as well as on OC biomarkers other than miRNAs. While the clinical need for an effective tool for OC screening remains unmet, it would be advisable to combine within a single diagnostic platform, the tools for detecting patterns of both protein and miRNA biomarkers to provide the screening robustness that single molecular species separately were not able to provide so far.

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Section: Saliva: An Informative Analyte For Mirna Detection With Prac...mentioning

confidence: 99%

Circulating Biomarkers for Cancer Detection: Could Salivary microRNAs Be an Opportunity for Ovarian Cancer Diagnostics?

2023

View full text Add to dashboard Cite

show abstract

The Use of Salivary as a Biometric Tool to Determine the Presence of Carcinoma of the Breast Among Women

Cited by 1 publication

References 13 publications

Circulating Biomarkers for Cancer Detection: Could Salivary microRNAs Be an Opportunity for Ovarian Cancer Diagnostics?

Circulating Biomarkers for Cancer Detection: Could Salivary microRNAs Be an Opportunity for Ovarian Cancer Diagnostics?

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