The Use of Routine Laboratory Tests in Postmortem Examinations

Fékéte, J.; Brunsdon, David F.V.

doi:10.1080/00085030.1974.10757216

Cited by 18 publications

(11 citation statements)

References 8 publications

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“…Total serum cholesterol, lipoproteins and apolipoproteins were stable for at least 24 h after death as already reported by several auhors [36][37][38][39][40]. Särkioja et al [41] however reported occasional unpredictable fluctuations of lipids and apolipoproteins during the 24 h-period after death and showed that triglycerides were the least stable.…”

Section: Discussionsupporting

confidence: 65%

The possible role of remnant-like particles as a risk factor for sudden cardiac death

Takeichi

Nakajima

Osawa

et al. 1997

International Journal of Legal Medicine

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Postmortem plasma lipid and lipoprotein levels were analyzed in two groups of Japanese subjects who died suddenly and unexpectedly due to cardiac (n = 93) or non-cardiac (n = 26) causes. No individuals in either group had a significant medical or cardiac history. In this study, we measured plasma total cholesterol, triglycerides, VLDL-cholesterol, LDL-cholesterol, HDL-cholesterol, and especially triglyceride-rich lipoprotein remnants. Triglyceride and apo E-rich remnant-like particles (RLP) were studied as a possible risk factor for sudden cardiac death in relation to the progression of coronary atherosclerosis. The receiver-operating characteristic curve (ROC) analysis showed that RLP-TG was the most significant risk factor for sudden cardiac death among the lipids and lipoproteins and RLP-C was the best predictor for coronary atherosclerosis. HDL-C and LDL-C levels were within normal limits in the majority of the cases and did not appear to relate to the sudden cardiac death. Apo E phenotyping was performed for the detection of the genetic background in the lipid metabolism. The frequency of the Apo E3/3 (wild type) phenotype, which closely relates with the remnant metabolism, was significantly reduced in the sudden cardiac death group. Our study on the postmortem plasma lipid analysis suggested that RLP-C and RLP-TG are the best risk predictor for coronary atherosclerosis and sudden cardiac death, respectively.

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Section: Discussionsupporting

confidence: 65%

The possible role of remnant-like particles as a risk factor for sudden cardiac death

Takeichi

Nakajima

Osawa

et al. 1997

International Journal of Legal Medicine

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“…One of the first literature reviews pertaining to cholesterol, triglyceride, and apolipoprotein stability in postmortem serum samples was provided by Coe [14,15], who reported the results of the studies performed by Naumann [16], Glanville [17], Enticknap [18][19][20], Fekete and Brunsdon [21], Sturner [22], Leadbeatter and Stansbie [23], and Särkioja [12].…”

Section: Discussionmentioning

confidence: 99%

“…The results of these studies provided contradictory findings concerning cholesterol, triglyceride, and apolipoprotein (A-I and B) stability in postmortem samples and hence postmortem determination reliability. In particular, postmortem serum triglyceride levels were characterized by significant fluctuations and appeared to be of very limited value as indicators of antemortem levels [12,[14][15][16][17][18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

Postmortem evaluation of cholesterol, triglyceride, and apolipoprotein levels

et al. 2017

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Cholesterol and triglyceride levels have been analyzed in the forensic setting and their values correlated with atherosclerotic lesions found at autopsy and histology. Nevertheless, the results of these investigations have provided diverging information on postmortem molecule stability and postmortem measurement reliability. The aim of this study was to determine triglycerides, total cholesterol, low-density and high-density lipoprotein cholesterol, apolipoprotein B, and apolipoprotein A-I in antemortem and postmortem serum samples in a series of cases (N = 10, including cardiac and noncardiac deaths) that underwent forensic investigations and had both samples available, measure the same molecules in postmortem serum from femoral blood and pericardial and pleural fluids (N = 39, including cardiac and noncardiac deaths), and evaluate whether different levels of these molecules could be observed in cases characterized by different degrees of coronary artery atherosclerosis (N = 39, including cardiac and noncardiac deaths). Preliminary results indicated that total cholesterol and low-density and high-density lipoprotein cholesterol levels in postmortem serum samples tended to be lower than those in antemortem specimens, whereas triglyceride levels in postmortem serum samples tended to be higher than those in antemortem samples. No relationship could be found between postmortem serum and pericardial fluid levels or between postmortem serum and pleural fluid levels of all tested biomarkers. Lastly, cases characterized by severe coronary artery atherosclerosis revealed higher postmortem serum levels of total cholesterol and apolipoprotein B. Globally considered, these data confirm that femoral blood postmortem serum levels of cholesterol and apolipoproteins may be considered suitable to estimate their antemortem values in forensic cases characterized by coronary artery atherosclerosis.

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“…In contrary to our study, Jetter [14] reported that the plasma calcium concentration was relatively stable from 12-24 h postmortem. Hodgkinson and Hambleton [17] found that plasma calcium concentration increased rapidly within an hour postmortem from 4 mmol/L to reach 9.4 mmol/L after 5 h before decreasing back to antemortem levels by 11 h. Fekete and Brunsdon [18] found a wide range of serum calcium concentrations within 2-36 h postmortem. All of these researchers used different methods to analyze serum calcium concentrations and that may explain why the findings are so variable, indicating that blood calcium levels are not a reliable indicator of PMI.…”

Section: Discussionmentioning

confidence: 99%

Postmortem Changes in Electrolytes and Adrenal Gland at Different Intervals in Adult Male Rats

2016

ARC Journal of Animal and Veterinary Sciences

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The importance of determining time of death is crucial to forensic cases. The ability to use electrolytes, ions and adrenal gland changes to determine the postmortem intervals were examined in this study.A total of 9 rats were used, three rats for determining postmortem "zero hour" the remaining 6 rats were divided equally into two groups to investigate postmortem "six hour" and postmortem "twelve hour".

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The Use of Routine Laboratory Tests in Postmortem Examinations

Cited by 18 publications

References 8 publications

The possible role of remnant-like particles as a risk factor for sudden cardiac death

The possible role of remnant-like particles as a risk factor for sudden cardiac death

Postmortem evaluation of cholesterol, triglyceride, and apolipoprotein levels

Postmortem Changes in Electrolytes and Adrenal Gland at Different Intervals in Adult Male Rats

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