The Use of Rosenmund Reduction in Organic Synthesis

Abstract

The diverse uses of commercially available Palladium (Pd) on barium sulfate, known as Rosenmund catalyst are described. Hydrogenation of acid chloride to aldehyde with poisoned palladium catalyst (Pd-BaSO4) is known as Rosenmund reduction. The Rosenmund reduction has also been used in the conversion of alkynes to cis-alkenes and hydrogenolysis of various functional groups. The regioselective opening of 1,2-disubstituted epoxide has been recorded with Rosenmund reduction.