The use of rituximab in myasthenia gravis and Lambert-Eaton myasthenic syndrome

Abstract

To cite this version:Paul Maddison. The use of Rituximab in myasthenia gravis and Lambert-Eaton myasthenic syndrome.

The Lambert-Eaton Myasthenic Syndrome

“…Other immunosuppressive drugs like ciclosporin or methotrexate have been used effectively in LEMS patients as well (Maddison et al 2001). Recently, rituximab was described to be effective in some LEMS patients with severe weakness, who were resistant to treatment with several different immunosuppressive drugs (Maddison et al 2011;Pellkofer et al 2009b).…”

Neurologıc Problems Accompanyıng Lung Cancer

“…Yanıt alınmama-sı halinde azotiopirin, kortikosteroid ya da siklosporin gibi immünoteropatik ajanlar ile plazma değişimi veya intravenöz immünglobulin (IVIG) tedavisi de kullanılabilir (42). Ayrıca tedavide rituximabın kullanıldığı vakalar da literatürde bulunmaktadır (43). Paraneoplastik retinal dejenerasyon ve Opsoklonus-Miyoklonus sendromunda, cerrahi ya da KT'nin uygulandığı tümör tedavisine ek olarak kortikosteroid, plasma değişimi ya da intravenöz immünglobulin tedavileri uygulanabilmektedir (38).…”

Positive experience of the usage of Rituximab in management of refractory myasthenia gravis in Russia

“…Имеются публикации об эффективности ритуксимаба в лечении рефрактер-ных случаев миастенического синдрома Ламберта-Итона [23]. По данным проведенного метаанализа [24], объединившего результаты 37 опубликованных исследований и сообщений по опыту применения ритуксимаба при миастении гравис, положительный результат был достигнут у 83,9 % больных.…”