2022
DOI: 10.1016/j.amsu.2022.103681
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The use of remdesivir among pregnant women and associated clinical outcomes in mother and the child

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Cited by 2 publications
(3 citation statements)
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“…As the COVID‐19 pandemic persists, many people continue to rely on antiviral treatments, such as RDV. Even though RDV is not generally recommended for pregnant people due to a lack of clinical trial data, it has been administered during pregnancy on a compassionate use basis (Budi et al, 2022 ; Burwick et al, 2021 ; Gutierrez et al, 2022 ; Jorgensen, Davis, & Lapinsky, 2021 ; Lampejo, 2021 ; Marzban‐Rad et al, 2022 ; Saroyo et al, 2021 ). There are registries to monitor pregnancy outcomes in individuals exposed to RDV (FDA, 2022 ; UKTIS, 2022 ), which are likely to provide crucial data for epidemiologic studies.…”
Section: Discussionmentioning
confidence: 99%
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“…As the COVID‐19 pandemic persists, many people continue to rely on antiviral treatments, such as RDV. Even though RDV is not generally recommended for pregnant people due to a lack of clinical trial data, it has been administered during pregnancy on a compassionate use basis (Budi et al, 2022 ; Burwick et al, 2021 ; Gutierrez et al, 2022 ; Jorgensen, Davis, & Lapinsky, 2021 ; Lampejo, 2021 ; Marzban‐Rad et al, 2022 ; Saroyo et al, 2021 ). There are registries to monitor pregnancy outcomes in individuals exposed to RDV (FDA, 2022 ; UKTIS, 2022 ), which are likely to provide crucial data for epidemiologic studies.…”
Section: Discussionmentioning
confidence: 99%
“…Regarding the safety of RDV, hepatotoxicity and nephrotoxicity have been implicated in human studies (Gérard et al, 2021 ; Satsangi, Gupta, & Kodan, 2021 ). However, the developmental toxicity of RDV, namely the adverse impact on embryos, is still unclear (Budi et al, 2022 ; Gutierrez et al, 2022 ; Marzban‐Rad, Ghafarzadeh, Bahmani, & Kazemi, 2022 ; Saroyo, Rumondang, Febriana, Harzif, & Irwinda, 2021 ). Due to the ongoing COVID‐19 pandemic, many people, including those who are pregnant or may become pregnant, will continue to be affected.…”
Section: Introductionmentioning
confidence: 99%
“…However, pregnant women were not included in this report. Several reviews reported the use of Rmd in pregnant women, 4–7 but did not analyse Rmd or GS concentration neither in mothers nor in cord blood. A physiological based PK model has been done to predict mother concentrations but without fetal concentrations 8 .…”
Section: Introductionmentioning
confidence: 99%