The use of recombinant human LH (lutropin alfa) in the late stimulation phase of assisted reproduction cycles: a double-blind, randomized, prospective study

Abstract

In this patient population, the addition of r-hLH during the late follicular phase of a long GnRH agonist and r-hFSH stimulation cycle provides no further benefit in terms of oocyte maturation or other end-points.

Recombinant luteinizing hormone supplementation to recombinant follicle-stimulation hormone during induced ovarian stimulation in the GnRH-agonist protocol: A meta-analysis

“…Four trials fulfilled the inclusion criteria [2,[8][9][10]. In 3 trials, the pituitary down-regulation with GnRH-a started in the mid-luteal phase of the preceding cycle and in 1 trial in the beginning of the menstrual cycle.…”

“…Tarlatzis et al [10] The trial was a double-blind, randomized, placebo-controlled, prospective study performed at six centres in four countries. Women were eligible for inclusion in the study if they aged between 18 and 37 years, had a normal uterus and two ovaries, and were scheduled to undergo controlled ovarian stimulation prior to IVF with ICSI.…”

“…However, there is still a considerable controversy on the need of additional LH supplementation in cycles of assisted reproduction techniques using a GnRH-a [10]. It has been proposed that "resting" concentrations of LH are sufficient to maintain steroidogenesis and normal folliculogenesis [11].…”

Osteo-regenerative potential of ovarian granulosa cells: An in vitro and in vivo study

“…This question was raised by the consideration that oocyte retrieval for ART, which offers a precious opportunity to collect granulosa cells, is frequently carried out from preovulatory follicles few hours before ovulation [32,33]. In these cases, as reported for human LGC [17], the follicles are punctured well after the gonadotropin treatment that mimic the LH pre-ovulatory surge, i.e.…”

Human choriogonadotropin prior to controlled ovarian stimulation and in vitro fertilization improves implantation, and pregnancy rates

“…Multiple permutations of FSH and LH administration during the mid-and late follicular phases have been investigated with varying degrees of success in obtaining oocytes with embryonic developmental competence and efficiency of establishing pregnancies [16][17][18][19][20]. Several studies have demonstrated that administration of LH activity alone or combined with FSH can exert significant actions on folliculogenesis [10,21].…”