The use of recombinant factor VIIA (rFVIIA) in laparoscopic liver biopsy (LB): A pilot trial

Effectiveness of the Recombinant Factor VIIa in Patients with the Coagulopathy of Advanced Child's B and C Cirrhosis

“…3 In an initial, single-center, dose escalation trial, three single doses of NovoSeven ® were administered to volunteer nonbleeding cirrhotic patients whose prothrombin times were greater than 2 seconds above the control value. 2 All the subjects in this trial were late-stage cirrhotics of Child's class B or C. The results of this study confirmed the initial hypothesis that NovoSeven ® would correct the abnormal prothrombin time in cirrhotic patients as all patients showed a normalization of prothrombin time after administration.…”

Recombinant Factor VIIa for Uncontrolled Bleeding in 2 Different Cases of Coagulopathy

“…An otolaryngologist saw the patient in the emergency department; the nose packing was replaced and 10 mg of vitamin K was administered. A repeat test at 12:45 am on March 21 showed that the PT/aPTT were 39.8/70 seconds, respectively, INR was 10, Hb/Hct were 10.2 g/dL and 0.345, and platelet count was 273,000/ cm 3 . On March 21 at 3:50 pm, PT/aPTT were shown to be higher at 47.5/80 seconds, respectively, INR was 14.2, Hb/Hct were 10.1 g/dL and 0.331, respectively, and platelet count was 260,000/ cm 3 .…”

“…A repeat test at 12:45 am on March 21 showed that the PT/aPTT were 39.8/70 seconds, respectively, INR was 10, Hb/Hct were 10.2 g/dL and 0.345, and platelet count was 273,000/ cm 3 . On March 21 at 3:50 pm, PT/aPTT were shown to be higher at 47.5/80 seconds, respectively, INR was 14.2, Hb/Hct were 10.1 g/dL and 0.331, respectively, and platelet count was 260,000/ cm 3 . Despite the administration of vitamin K again, the patient continued to bleed profusely, soaking the nasal packing.…”

“…2 Patients with liver cirrhosis and coagulopathy who were given rF.VIIa avoided bleeding complications when their liver biopsies were performed. 3 Administration of rF-.VIIa controls the bleeding in trauma-related multitransfusion dilutional coagulopathy. 4,5 It also stops uncontrolled nasal and dental bleeding in patients on warfarin.…”

Rekombinanter Faktor VIIa (NovoSeven®) Ein Überblick über aktuelle und mögliche zukünftige Indikationen

“…B. Leberbiopsie) als auch zur Therapie manifester Blutungen sowie während orthotoper Lebertransplantationen (OLT) [1,7,9,15,29,34,35,37,40,55,57]. An dieser Stellle wird jedoch erwähnt, dass in der von Hendriks et al publizierten Pilotstudie [29] mit rFVIIa bei OLT einer von insgesamt 6 behandelten Patienten eine Thrombose der A. hepatica propria entwickelt hat.…”