The use of psychostimulants in cancer patients

Portela, María Angustias; Rubiales, Álvaro Sanz; Centeno, Carlos

doi:10.1097/spc.0b013e3283462ff3

Cited by 29 publications

(9 citation statements)

References 20 publications

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“…Although some agents such as cholinesterase inhibitors, modafinil, and anti-inflammatory agents were tried clinically to treat chemobrain, nonavailability of an effective intervention is still a major lacuna 15,16. Complementary and alternative medicine have become promising sources of new drugs of reliable therapeutic potential with a history of long traditional use 17.…”

Section: Introductionmentioning

confidence: 99%

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

Ramalingayya

Cheruku

Nayak

et al. 2017

DDDT

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Doxorubicin (DOX) is the most widely used broad-spectrum anticancer agent, either alone or in combination, for most cancers including breast cancer. Long-term use of chemotherapeutic agents to treat breast cancer patients results in cognitive complications with a negative impact on survivors’ quality of life. The study objective was to evaluate rutin (RUT) for its neuroprotective effect against DOX in human neuroblastoma (IMR32) cells in vitro and study its potential to ameliorate DOX-induced cognitive dysfunction in Wistar rats. Cell viability assay (3-[4,5 dimethyl thiazol-2-yl]-2,5-diphenyl tetrazolium bromide), neurite growth assay, detection of apoptosis by (acridine orange/ethidium bromide) staining, intracellular reactive oxygen species (ROS) assay, and flowcytometric analysis were carried out to assess neuroprotective potential against DOX. An in vivo study was conducted for assessing protective effect of RUT against memory deficit associated with DOX-induced chemobrain using object recognition task (ORT). Locomotion was assessed using open field test. Serum biochemistry, acetylcholinesterase, oxidative stress markers in hippocampus, and frontal cortex were assessed. Histopathological analysis of major organ systems was also carried out. Prior exposure to RUT at 100 µM protected IMR32 cells from DOX (1 µM) neurotoxicity. DOX exposure resulted in increased cellular death, apoptosis, and intracellular ROS generation with inhibition of neurite growth in differentiated IMR32 cells, which was significantly ameliorated by RUT. Cognitive dysfunction was induced in Wistar rats by administering ten cycles of DOX (2.5 mg/kg, intra-peritoneal, once in 5 days), as we observed significant impairment of episodic memory in ORT. Coadministration with RUT (50 mg/kg, per os) significantly prevented memory deficits in vivo without any confounding influence on locomotor activity. RUT also offered protection against DOX-induced myelosuppression, cardiotoxicity, and nephrotoxicity. In conclusion, RUT may be a possible adjuvant therapeutic intervention to alleviate cognitive and other complications associated with DOX chemotherapy.

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Section: Introductionmentioning

confidence: 99%

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

Ramalingayya

Cheruku

Nayak

et al. 2017

DDDT

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“…MPH-related increases of general IQ levels were reported in children with neurofibromatosis type 1 ( 47 ). Moreover, positive effects of low doses (0.3 mg/kg) of MPH on attention and social functioning in survivors of brain tumors and leukemia in childhood ( 44 ) were found, but do hardly generalize to academic performance and success ( 45 , 48 ). Similarly, children with sickle cell disease showed isolated MPH-related improvements in inhibitory control, while other executive functions and behavior resembling symptoms of attention-deficit hyperactivity disorder (ADHD) were not improved ( 46 ).…”

Section: Pharmacological Interventions—current Practice and Caveatsmentioning

confidence: 99%

Executive Function Deficits in Seriously Ill Children—Emerging Challenges and Possibilities for Clinical Care

et al. 2018

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The past years have seen an incredible increase in the quality and success rates of treatments in pediatric medicine. One of the resulting major challenges refers to the management of primary or secondary residual executive function deficits in affected children. These deficits lead to problems in the ability to acquire, understand, and apply abstract and complex knowledge and to plan, direct, and control actions. Executive functions deficits are important to consider because they are highly predictive of functioning in social and academic aspects of daily life. We argue that current clinical practice does not sufficiently account for the complex cognitive processes in this population. This is because widely applied pharmacological interventions only rarely account for the complexity of the underlying neuronal mechanisms and do not fit well into possibly powerful “individualized medicine” approaches. Novel treatment approaches targeting deficits in executive functions in seriously ill children could focus on neuronal oscillations, as these have some specific relations to different aspects of executive function. Importantly, such treatment approaches can be individually tailored to the individuals’ deficits and can be transferred into home-treatment or e-health solutions. These approaches are easy-to-use, can be easily integrated into daily life, and are becoming increasingly cost-effective.

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“…Por otra parte, la anhedonia supondría una característica diferencial entre ambos cuadros clínicos, ya que la capacidad de disfrutar continua presente en una gran proporción de pacientes desmoralizados y no en los deprimidos. Esto explicaría el beneficio que parecen aportar los psicoestimulantes en pacientes paliativos (39) .…”

Section: Cuestionarios De Evaluación De La Depresión En Pacientes Palunclassified

Síndrome de desmoralización como alternativa diagnóstica al estado de ánimo deprimido en pacientes paliativos

et al. 2016

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El estado de ánimo de los pacientes paliativos es uno de los objetivos fundamentales en la atención profesional a los mismos. Distintos autores han estudiado dicho estado de ánimo tomando como base definiciones de la depresión tal como se entiende en la población general. Son muchas las voces y los datos de investigación que apuntan a la necesidad de adecuar la investigación a la situación del paciente en final de vida. Quizá una de las ideas más interesantes es la planteada por Frank y desarrollada por Kissanne y colaboradores, proponiendo la diferenciación entre depresión y desmoralización. Siguiendo esta línea de pensamiento, la desmoralización reflejaría mejor la situación observada en estos pacientes, permitiendo un mejor diagnóstico diferencial y promoviendo un afinamiento mayor en las intervenciones. El síndrome de desmoralización vendría definido como la presencia de desánimo, desaliento, desamparo, pérdida de sentido de la vida y fracaso, sin que los síntomas somáticos propios de la conceptualización de la depresión tengan un peso importante. Teniendo en cuenta esta definición, las intervenciones psicológicas tendrían unos objetivos operativos distintos al tratamiento de depresión, obteniéndose resultados en el bienestar del paciente paliativo. En este trabajo se realiza un planteamiento crítico

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The use of psychostimulants in cancer patients

Cited by 29 publications

References 20 publications

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

Rutin protects against neuronal damage in vitro and ameliorates doxorubicin-induced memory deficits in vivo in Wistar rats

Executive Function Deficits in Seriously Ill Children—Emerging Challenges and Possibilities for Clinical Care

Síndrome de desmoralización como alternativa diagnóstica al estado de ánimo deprimido en pacientes paliativos

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