The Use of Proton Pump Inhibitors in Children

Oropharyngeal Dysphagia in Children

“…85 Thus, a higher dose per kilogram or twice-daily dosing is recommended-lansoprazole (0.73-1.66 mg/kg) or omeprazole (0.3-3.5 mg/kg). 86 PPIs are recommend for GERD in patients 1 year or older and are not proved effective in infants. 87 Caution has been advised regarding the use of PPIs in infants, particularly those with increased risk of lower respiratory tract infections, after a multicentric randomized trial demonstrated that lower respiratory tract infections were more common in children on PPI than those on placebo.…”

Pediatric surgeons and gastroesophageal reflux

“…The experience gained in adults and children [4,5] with proton pump inhibitors (PPI) as a powerful long-term medication for GERD and some critical judgements on antireflux surgery by influential pediatric gastroenterologists [6][7][8][9][10] have thrown doubts in the pediatric arena about its indications. These authors claim that long-term PPI treatment may be less dangerous than operations in which high rates of complications, wrap malfunction, and even mortality are to be expected.…”

Pediatric and adolescent GERD

“…However, the proton pump inhibitors (PPIs) that are US Food and Drug Administration approved for use in children-omeprazole, lansoprazole, and esomeprazole-are superior to histamine-2 receptor antagonists in relieving symptoms and promoting mucosal healing in children and adolescents with GERD [31]. In an open-labeled study in 87 adolescents (12-17 years) with GERD (64 with nonerosive esophagitis and 23 with erosive esophagitis), Fiedorek et al [32] found that lansoprazole produced a significant reduction from baseline in the median percentage of days with symptoms of GER (91% to 43% in adolescents with nonerosive esophagitis and 85% to 16% in adolescents with erosive esophagitis).…”