The use of prostaglandin E1 for diagnosis and treatment of erectile dysfunction

Stackl, W.; Hasun, R.; Marberger, Michael

doi:10.1007/bf01576353

Cited by 21 publications

(12 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pain or discomfort after PGE injection has been recorded in several studies. 4,42,43 In this present study, this was the third most important source of dissatisfaction, but more often in the younger age groups. This problem could have been solved by simply switching the subjects over to papaverineaphentolamine which is acknowledged not to cause this type of discomfort.…”

Section: Discussionsupporting

confidence: 42%

“…Approximately one third (32.1%) reported losing their erections after ejaculation whereas one quarter (24.3%) maintained rigidity and over 43.5% recorded only a partial loss of rigidity after ejaculation. This response appeared to be age-related and indicated that twice as many men in the over-seventies age group as those less than forty, lost rigidity after ejaculation ( Table 3).…”

Section: Effects Of Ejaculationmentioning

confidence: 99%

See 1 more Smart Citation

Intracavernosal therapy for erectile failure—Impact of treatment and reasons for drop-out and dissatisfaction

Purvis¹,

Egdetveit²,

Christiansen³

1999

Int J Impot Res

View full text Add to dashboard Cite

Objectives: To examine the impact of intracavernosal therapy on libido, ejaculatory control, quality of life and treatment dependency in men with erectile failure. Furthermore to assess the drop-out rate and reasons for dissatisfaction with the technique. Subjects and methods: Questionnaires were sent to 1116 subjects with erectile failure who had previously elected to use intracavernosal therapy in the period 1995 ± 1997. Results: The response rate was 72.5%. The majority of erections lasted 30 ± 60 min, 10 ± 20% of the erections were considered unsatisfactory for intercourse and 15% of subjects reported erections lasting longer than 5 h on at least 10% of the occasions. Bleeding at the injection site occurred in 60% on at least 10% of the occasions and various degrees of deformation of the penis shaft were reported by 10%. The latter was related to the age of the subject and not the type of medication employed. Forty percent experienced at least partially improved control over ejaculation and almost 50% experienced some degree of increase in libido. One quarter retained penile rigidity after ejaculation but this was age-dependent. In those satis®ed with intracavernosal treatment, 80% admitted that it had improved the quality of their lives. Sixty percent did not feel that their dependency on intracavernosal treatment had lessened during the treatment period.Approximately 40% of subjects admitted to dropping out of the programme, the majority within the ®rst six months. The age of the subject did not in¯uence the decision and the type of medication or the mode of injection had only a minor impact on drop-out rate. Of those currently using IC therapy, 87% were either fully or partly satis®ed with this form of treatment. The corresponding ®gure for those discontinuing treatment was 58%. Dissatisfaction was higher in the younger age groups and could not be clearly related to the mode of injection. The major reasons for drop out or dissatisfaction were inadequate penile rigidity, the expense of the treatment, penile discomfort and the lack of spontaneity it necessitated. Penile discomfort was more associated with younger age groups, whilst an inadequate response to medication was more often experienced by men over 60 y. Deformation of the penile shaft was observed in 5% of those dissatis®ed with IC therapy and was four times more often reported by those over 70 compared to subjects younger than 40 y. In 6% of cases, a return of spontaneous erections was given as reason for drop-out. This was more often associated with younger subjects. In 16% of the subjects, the partner had expressed dissatisfaction with the technique primarily because of inadequate rigidity, lack of spontaneity or the complicated nature of the treatment.Conclusions:Intracavernosal treatment for erection failure is associated with side-effects such as penile ®brosis and bleeding at the injection site but has advantages including increased libido, an increase in the quality of life and ejaculatory control. Only a small proportion of men reduce thei...

show abstract

Section: Discussionsupporting

confidence: 42%

Section: Effects Of Ejaculationmentioning

confidence: 99%

Intracavernosal therapy for erectile failure—Impact of treatment and reasons for drop-out and dissatisfaction

Purvis¹,

Egdetveit²,

Christiansen³

1999

Int J Impot Res

View full text Add to dashboard Cite

show abstract

“…1±5 Several drugs have been employed, including papaverine with or without phentolamine, 6 prostaglandin E 1 (PGE 1 ) 7 and more recently the combination of these drugs. 8 The aim of the present work was to evaluate the usefulness of a mixture of three vasoactive drugs (TRIMIX), the complications associated with its use, and the reasons for discontinuing treatment with VAS.…”

Section: Introductionmentioning

confidence: 99%

Drop-out reasons and complications in self-injection therapy with a triple vasoactive drug mixture in sexual erectile dysfunction

et al. 1998

View full text Add to dashboard Cite

The usefulness, complications and reasons for discontinuing the self-injection program with a combination of papaverine, phentolamine and prostaglandin E 1 were evaluated in 189 patients (mean age 57.2 y), who were included from April 1993 to September 1995 (mean follow-up 10.25 months).Patients were split into two groups: Active, those who continued with the program (48%); and Inactive, those who discontinued treatment or failed to attend consultation after ®ve months from the last visit (52%).Only 30% of the inactive group reported failure to achieve response with the self-injected doses. Fibrosis in 5.3% and prolonged erection in 3.7% were the most severe complications. Patients lacking organic pathology showed a clear tendency to reduce the drug dose during treatment, recover spontaneous erections and discontinue the program for reasons unrelated to drug ef®cacy.The triple drug mixture provides an effective alternative in the treatment of impotence, with a low rate of complications.

show abstract

“…Intracavernosal injection therapy is generally accepted as very effective and safe with satisfaction rates as great as 80% for the patient and partner. 7,8 However for many patients with ED particularly the older patient it is ineffective mainly due to signi®cant vascular insuf®ciency. It is in these patients that an alternative treatment modality is required.…”

Section: Discussionmentioning

confidence: 99%

Fifteen years experience of penile prosthesis insertion

1997

View full text Add to dashboard Cite

Introduction and Objectives: To review the outcome and patient satisfaction of penile prosthesis insertion over a 15 y period. Patients/Materials and Methods: We reviewed the notes of 172 patients who underwent penile prosthesis insertion between January 1980 and May 1995. From the notes information was determined on age of the patient, type of prosthesis, surgical approach and length of stay. Also noted were risk factors for erectile dysfunction and the aetiology. Twenty patients were known to have died or moved away. To assess the impact the operation had on quality of life, 152 questionnaires were sent of which 103 were returned (67%). The questionnaire gained information about sexual activity, before and after the operation and the overall satisfaction of the patient and his partner and whether they felt the operation was a success. Results: Overall 149 patients were known to have had malleable prostheses inserted and 23 had in¯atables. The commonest organic groups were vascular disease, diabetes and Peyronies disease. Fifteen patients had two procedures. Four patients required revision of the prosthesis due to erosion, and there was one death due to pulmonary embolism. One hundred and three completed questionnaires have been returned to date the median time since operation was 4 y, the range being six months to 16 y and 78% thought the operation was a success. Conclusions: The insertion of malleable prostheses is associated with low complication rates, good patient satisfaction and improved quality of life for the couple. Concealment was not a major problem.

show abstract

The use of prostaglandin E1 for diagnosis and treatment of erectile dysfunction

Cited by 21 publications

References 13 publications

Intracavernosal therapy for erectile failure—Impact of treatment and reasons for drop-out and dissatisfaction

Intracavernosal therapy for erectile failure—Impact of treatment and reasons for drop-out and dissatisfaction

Drop-out reasons and complications in self-injection therapy with a triple vasoactive drug mixture in sexual erectile dysfunction

Fifteen years experience of penile prosthesis insertion

Contact Info

Product

Resources

About