The Use of Propolis in Micro/Nanostructured Pharmaceutical Formulations

Bruschi, Marcos Luciano; Pereira, Raphaela Regina de Araújo; Francisco, Lizziane Maria Belloto de

doi:10.2174/1872211310666151230112616

Cited by 13 publications

(5 citation statements)

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“…Pharmaceutical analysis of propolis is a difficult task, as it is often composed of a complex mixture of compounds [95]. As future perspectives, we observe a low number of works involving propolis and pharmaceutical formulations with technological potential, structured micro and nanoformulations, which can improve their biological activity and reduce interference with other drugs in addition to improving the delivery system [96].…”

Section: Future Perspectivesmentioning

confidence: 99%

Advances in the phytochemical screening and biological potential of propolis

Junior

Ferraz

Oliveira

et al. 2023

Fundamemntal Clinical Pharma

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Propolis is a natural resinous product collected from different parts of plants by bees and mixed with their salivary secretions. The occurrence of more than 180 different chemotypes has flavonoids, phenolic acids, esters, and phenolic aldehydes, as well as balsamic resins, beeswax, pollen, and essential and aromatic oils, among others. Its biological potential documented throughout the world justifies the need, from time to time, to organize reviews on the subject, with the intention of gathering and informing about the update on propolis. In this review (CRD42020212971), phytochemical advances, in vitro, in vivo, and clinical biological assays of pharmacological interest are showcased. The focus of this work is to present propolis clinical safety assays, antitumor, analgesic, antioxidant, anti‐inflammatory, and antimicrobial activities. This literature review highlights propolis' promising biological activity, as it also suggests that studies associating propolis with nanotechnology should be further explored for enhanced bioprocessing applications.

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Section: Future Perspectivesmentioning

confidence: 99%

Advances in the phytochemical screening and biological potential of propolis

Junior

Ferraz

Oliveira

et al. 2023

Fundamemntal Clinical Pharma

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“…This can be attributed to the lack of suitable formulations of the compound and difficulty in fabrication of appropriately stable formulations. Its poor water solubility issue also makes it difficult to formulate it in a dosage form (Bruschi, Pereira, & de Francisco, 2016; Pereira & Bartolo, 2016). The nanotechnological interventions are likely to enhance the pharmaceutical performances of this promising compound by improving its aqueous solubility, bioavailability, controlled‐release profile, and enhanced penetration capacity (Patra et al, 2018).…”

Section: Propolis To Nanopropolis: a Paradigm Shiftmentioning

confidence: 99%

From propolis to nanopropolis: An exemplary journey and a paradigm shift of a resinous substance produced by bees

Javed

Mangla

Ahsan

2022

Phytotherapy Research

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Propolis, a natural resinous mixture produced by honey bees is poised with diverse biological activities. Owing to the presence of flavonoids, phenolic acids, terpenes, and sesquiterpenes, propolis has garnered versatile applications in pharmaceutical industry. The biopharmaceutical issues associated with propolis often beset its use as being too hydrophobic in nature; it is not absorbed in the body well. To combat the problem, various nanotechnological approaches for the development of novel drug delivery systems are generally applied to improve its bioavailability. This paradigm shift and transition of conventional propolis to nanopropolis are evident from the literature wherein a multitude of studies are available on nanopropolis with improved bioavailability profile. These approaches include preparation of gold nanoparticles, silver nanoparticles, magnetic nanoparticles, liposomes, liquid crystalline formulations, solid lipid nanoparticles, mesoporous silica nanoparticles, etc. Nanopropolis has further been explored to assess the potential benefits of propolis for the development of futuristic useful products such as sunscreens, creams, mouthwashes, toothpastes, and nutritional supplements with improved solubility, bioavailability, and penetration profiles. However, more high-quality clinical studies assessing the effects of propolis either alone or in combination with synthetic drugs as well as natural products are warranted and its safety needs to be firmly established.

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“…The flavonoids present in propolis make it biologically active. In addition to possessing specific biochemical properties, flavonoids can attach to ions [12]. The antibacterial properties of propolis can prevent bacteria from becoming resistant to antibiotics due to its natural antibiotic properties [13].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial properties of green synthesized novel TiO₂ nanoparticles using Iranian propolis extracts

et al. 2023

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The oral antimicrobial and cytotoxic properties of green synthesized novel titanium dioxide nanoparticles (TiO2 NPs) using Iranian propolis extracts were investigated on oral bacteria and fibroblast cells. In this study, propolis was sampled, and alcoholic extracts were prepared. The TiO2 NPs were biosynthesized using propolis extracts. The synthesized TiO2 NPs were characterized by scanning electron microscope (SEM), X‐ray diffraction analysis, energy‐dispersive X‐ray (EDX), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering, ultraviolet–visible (UV–Vis), transmission electron microscope, Brunauer–Emmett–Teller, and zeta potential. MTT (3‐[4,5‐dimethylthiazol‐2‐yl]‐2,5 diphenyl tetrazolium bromide), minimal inhibitory concentration, minimum bactericidal concentration, minimum fungicidal concentration, biofilm formation, and degradation tests were studied to clarify the oral antimicrobial properties of green synthesized TiO2 NPs. According to the FTIR analysis, the propolis extract contained flavonoids and phenolic compounds in addition to TiO2 NPs. Additionally, UV‐Vis revealed that intense bands had formed NPs. EDX spectra and SEM images revealed that the stabilizing agent was in perfect quasi‐spherical shapes around 21 nm. An EDX spectrum was used to verify the presence of titanium and oxygen. There were no significant cytotoxicity effects. The antibacterial results showed that Pro1TiO2 (Khalkhal sample) had better effects than Pro2TiO2 (Gilan sample) and TiO2 NPs. The present study presents a new process for synthesizing TiO2 NPs from propolis extracts with less toxic effects and user‐friendly, eco‐friendly, and economical materials. Pro1TiO2 NPs may be considered the best candidate for clinical application.

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The Use of Propolis in Micro/Nanostructured Pharmaceutical Formulations

Abstract: This work reviews the recent studies of development of micro/nanostructured systems using propolis or its byproduct. In addition, patents were reviewed and categorized.

Cited by 13 publications

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Advances in the phytochemical screening and biological potential of propolis

Advances in the phytochemical screening and biological potential of propolis

From propolis to nanopropolis: An exemplary journey and a paradigm shift of a resinous substance produced by bees

Antimicrobial properties of green synthesized novel TiO₂ nanoparticles using Iranian propolis extracts

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The Use of Propolis in Micro/Nanostructured Pharmaceutical Formulations

Abstract: This work reviews the recent studies of development of micro/nanostructured systems using propolis or its byproduct. In addition, patents were reviewed and categorized.

Cited by 13 publications

References 0 publications

Advances in the phytochemical screening and biological potential of propolis

Advances in the phytochemical screening and biological potential of propolis

From propolis to nanopropolis: An exemplary journey and a paradigm shift of a resinous substance produced by bees

Antimicrobial properties of green synthesized novel TiO2 nanoparticles using Iranian propolis extracts

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Product

Resources

About

Antimicrobial properties of green synthesized novel TiO₂ nanoparticles using Iranian propolis extracts