The use of probiotics for improving lipid profiles in dyslipidemic individuals: an overview protocol

Abstract

BackgroundDyslipidemia is a major risk factor in triggering cardiovascular events, which can lead to the death of millions of people around the world. Thus, several pharmacological and non-pharmacological therapeutic strategies have been developed in recent decades with the objective of improving lipid profiles, including the use of probiotics. Therefore, the purpose of this protocol is to describe the steps that will guide the construction of an overview to demonstrate the scientific evidence of the efficacy of probiotics in improving the lipid profile of dyslipidemic individuals and to propose specific recommendations regarding their use.MethodsThe search will be conducted in the following databases: MEDLINE/PubMed, EMBASE, PROSPERO, Cochrane Library, CINAHL, JBI Database of Systematic Reviews and Implementation Reports, Google Scholar, and CADTH. Reviewers will select systematic evaluations and data analyses from randomized clinical trials that evaluated the effects of probiotics on lipid profiles. The studies will be analyzed for methodology quality by the AMSTAR 2 tool and risk of bias by ROBIS. The data will be extracted by three independent reviewers based on a data extraction sheet, which will include the most relevant variables for the analysis and interpretation of the results. The variables will be categorized and described in narrative form or in tables.DiscussionThere are some systematic reviews about the use of probiotics to prevent and/or treat dyslipidemia; however, their outcomes related to the ability of probiotics to improve lipid profiles are conflicting. So, an overview on this topic is needed to clarify this important issue.Systematic review registrationPROSPERO CRD42017080328Electronic supplementary materialThe online version of this article (10.1186/s13643-018-0826-2) contains supplementary material, which is available to authorized users.

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“…Depth of sleep and energizing effects of kefir was also from very remarkable findings of this case, as reported by the patient[26]. Many studies have shown results similar to the results we obtained from this study showing that supplementation with probiotics significantly reduced total cholesterol, LDL-c, and triglycer-ides and increased HDL-c[27][28][29][30]…”

Methodological Quality and Risk of Bias of Systematic Reviews and Meta-Analyses on Stem Cells for Knee Osteoarthritis: A Cross-Sectional Survey

“…For gray literature retrieval, only 4.55% (n=1) of the SRs/MAs searched the gray literature database [11], and (n=6) searched the clinical trial platform [11,[27][28][29]43]. Winters et al [97] proposed three methods to control the publication bias, namely, (1) registering before the start of the trial, (2) using a funnel to evaluate the publication bias intuitively, and (3) using comprehensive retrieval strategy multiple gray literature Unpublished studies may signi cantly change the clinical effect of SRs/MAs, and more comprehensive literature retrieval strategies be developed in the The AMSTAR 2 and have used in combination in diverse elds such as heart failure [98], dyslipidemia [99], infertility [100], and psoriasis [101]. It has been con rmed that there is a strong use of AMSTAR 2 and ROBIS tools for evaluation and the methodological quality [102,103].…”

Methodological Quality and Risk of Bias of Systematic Reviews and Meta-Analyses on Stem Cells for Knee Osteoarthritis: A Cross-Sectional Survey

“…The AMSTAR 2 and ROBIS tools have been used in combination in diverse elds such as chronic heart failure [98], dyslipidemia [99], infertility [100], and psoriasis [101]. It has been con rmed that there is a strong between the use of AMSTAR 2 and ROBIS tools for evaluation and the methodological quality [102,103].…”