The use of polyurethane materials in the surgery of the spine: a review

John, Kenneth R.

doi:10.1016/j.spinee.2014.08.012

Cited by 49 publications

(18 citation statements)

References 63 publications

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“…Polyurethane (PU) is a macromolecule containing carbamate units in the main chain. Owing to its excellent physical, chemical, and mechanical properties, PU had been widely used in biomedical applications including artificial heart systems, catheters, mammary implants, semiocclusive dressings, and drug‐delivery systems, which is often introduced into the body through surgery or injection into the body and can be monitored by X‐radiography after adding the contrast agents . Unfortunately, traditional PUs are synthesized by reacting a di‐ or polyisocyanate with polyols.…”

Section: Introductionmentioning

confidence: 99%

“…Owing to its excellent physical, chemical, and mechanical properties, PU had been widely used in biomedical applications including artificial heart systems, catheters, mammary implants, semiocclusive dressings, and drug-delivery systems, which is often introduced into the body through surgery or injection into the body and can be monitored by Xradiography after adding the contrast agents. [5][6][7] Unfortunately, traditional PUs are synthesized by reacting a di-or polyisocyanate with polyols. Due to the high volatility of the isocyanates, the trace unreacted isocyanates can enter the body through the respiratory tract, skin, etc., resulting in a variety of acute and chronic injuries, such as bronchial asthma, pneumonia, pulmonary edema, chronic obstructive pulmonary disease, and hepatomegaly.…”

Section: Introductionmentioning

confidence: 99%

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Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Liu

Zhang

et al. 2018

J of Applied Polymer Sci

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Polyurethane (PU) is widely used in biomedical applications owing to its excellent physical and chemical properties. As an isocyanate‐free PU material, fluorescent poly(hydroxyurethane) (FPHU) is synthesized from the addition of the cyclic carbonates with amines rather than the toxic isocyanate with diols, which reduces the possible injury to the human due to trace amounts of the isocyanate residues. Herein, we report the biocompatibility of a FPHU that can be synthesized from carbon dioxide, bisepoxides, and diamine in tandem. Of unique, FPHU exhibits a strong blue fluorescence and is selectively sensitive to Fe3+ with a detection limit of 4.56 μM. The overall results of the methylthiazolyldiphenyl‐tetrazolium, cytokine release, and hemolysis assays for FPHU indicates that FPHU has much lower cytotoxicity and immunotoxicity compared with the traditional isocyanate PU, as well as a good blood compatibility with less than 5% hemolysis rate. Therefore, FPHU presents as a kind of safer PU and can be prospectively applied in medical materials.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Liu

Zhang

et al. 2018

J of Applied Polymer Sci

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“…The dynamic behavior of a PDSS is obtained by either incorporating a rubber-like material, e.g., silicone or polycarbonate urethane (PCU), or by reducing the structural stiffness, e.g., by using mechanical springs. Numerous spinal implants incorporate PCU for its mechanical properties and biocompatibility (Beckmann et al, 2018;St. John, 2014).…”

Section: Introductionmentioning

confidence: 99%

Biomechanical testing of a polycarbonate-urethane-based dynamic instrumentation system under physiological conditions

Beckmann

Herren

Nicolini

et al. 2019

Clinical Biomechanics

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“…Polyurethanes (PUs) are becoming more and more important as engineering materials because of their excellent abrasion resistance and the properties of both rubber and plastics [1,2,3]. The hard-segment-rich and soft-segment-rich domains existing in PUs contribute to the specific microphase-separated structure, which give them unique mechanical properties [4].…”

Section: Introductionmentioning

confidence: 99%

Preparation, Physicochemical Properties and Hemocompatibility of Biodegradable Chitooligosaccharide-Based Polyurethane

Xiao

Yuan

et al. 2018

Polymers

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The purpose of this study was to develop a process to achieve biodegradable chitooligosaccharide-based polyurethane (CPU) with improved hemocompatibility and mechanical properties. A series of CPUs with varying chitooligosaccharide (COS) content were prepared according to the conventional two-step method. First, the prepolymer was synthesized from poly(ε-caprolactone) (PCL) and uniform-size diurethane diisocyanates (HBH). Then, the prepolymer was chain-extended by COS in N , N -dimethylformamide (DMF) to obtain the weak-crosslinked CPU, and the corresponding films were obtained from the DMF solution by the solvent evaporation method. The uniform-size hard segments and slight crosslinking of CPU were beneficial for enhancing the mechanical properties, which were one of the essential requirements for long-term implant biomaterials. The chemical structure was characterized by FT-IR, and the influence of COS content in CPU on the physicochemical properties and hemocompatibility was extensively researched. The thermal stability studies indicated that the CPU films had lower initial decomposition temperature and higher maximum decomposition temperature than pure polyurethane (CPU-1.0) film. The ultimate stress, initial modulus, and surface hydrophilicity increased with the increment of COS content, while the strain at break and water absorption decreased, which was due to the increment of crosslinking density. The results of in vitro degradation signified that the degradation rate increased with the increasing content of COS in CPU, demonstrating that the degradation rate could be controlled by adjusting COS content. The surface hemocompatibility was examined by protein adsorption and platelet adhesion tests. It was found that the CPU films had improved resistance to protein adsorption and possessed good resistance to platelet adhesion. The slow degradation rate and good hemocompatibility of the CPUs showed great potential in blood-contacting devices. In addition, many active amino and hydroxyl groups contained in the structure of CPU could carry out further modification, which made it an excellent candidate for wide application in biomedical field.

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The use of polyurethane materials in the surgery of the spine: a review

Cited by 49 publications

References 63 publications

Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Fluorescent poly(hydroxyurethane): Biocompatibility evaluation and selective detection ofFe(III)

Biomechanical testing of a polycarbonate-urethane-based dynamic instrumentation system under physiological conditions

Preparation, Physicochemical Properties and Hemocompatibility of Biodegradable Chitooligosaccharide-Based Polyurethane

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