The Use of Poly-4-Hydroxybutyrate (P4HB) Scaffold in the Ptotic Breast: A Multicenter Clinical Study

Adams, William P.; Baxter, Richard A.; Glicksman, Caroline; Mast, Bruce A.; Tantillo, Michael B.; Natta, Bruce W. Van

doi:10.1093/asj/sjy022

Cited by 26 publications

(32 citation statements)

References 20 publications

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“… 17 Many operators who have a 3-D system still rely on 1-dimensional surface measurements. 10 , 11 , 14 …”

Section: Discussionmentioning

confidence: 99%

Photometric Evaluation of Long-term Changes in Breast Shape after Breast Augmentation and Vertical Mammaplasty

Swanson¹

2018

Plastic and Reconstructive Surgery - Global Open

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Background:Little information is presently available regarding the long-term effects of breast augmentation and mammaplasties on breast shape. Existing studies typically use 1-dimensional measurements and mean follow-up times seldom exceed 1 year.Methods:Twenty women were studied: breast augmentation (n = 5), mastopexy (n = 5), augmentation/mastopexy (n = 5), and breast reduction (n = 5). For mammaplasties, a vertical method using a medial pedicle and intraoperative nipple siting was used in all cases. A 2-dimensional measurement system was used, with computer-assisted matching of lateral photographs of the right and left breasts. Measurements were evaluated at 3 times: before surgery, 1 year after surgery, and 10 years after surgery.Results:Breast implants significantly increased breast projection and upper pole projection. The nipple level was unchanged. The lower pole level dropped. These changes were preserved at 10 years. Vertical mastopexy provided a modest increment in breast projection and upper pole projection. The nipple level and lower pole level were raised significantly. Augmentation/mastopexy boosted breast projection and upper pole projection, and also elevated the nipple and lower pole level. Breast reduction changes were similar to mastopexy, but with greater elevation of nipple level and lower pole level, which were usually lower to start with. Implants increased upper pole convexity. Nipple overelevation was avoided by intraoperative nipple siting just below the breast apex.Conclusions:These measurements provide new information regarding the long-term effects of breast augmentation and vertical mammaplasties. This information may be used by plastic surgeons in procedure selection and patient counseling.

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“… 17 Many operators who have a 3-D system still rely on 1-dimensional surface measurements. 10 , 11 , 14 …”

Section: Discussionmentioning

confidence: 99%

Photometric Evaluation of Long-term Changes in Breast Shape after Breast Augmentation and Vertical Mammaplasty

Swanson¹

2018

Plastic and Reconstructive Surgery - Global Open

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“…32 A recent article advocating the off-label use of implantable mesh in breast surgery was published by 2 authors who have a financial stake in the company that manufactures the mesh. 33 A third author is a paid consultant and speaker. Galatea Surgical, a subsidiary of Tepha Inc. (Lexington, Ma.)…”

Section: Examples Of Conflict Of Interest In Plastic Surgerymentioning

confidence: 99%

“…financed the study, including medical writing, and referenced supplemental publications. 33 Galatea is a corporate sponsor of the American Society for Aesthetic Plastic Surgery. 34 The authors report that 100% of participating surgeons preferred to use mesh in all patients and the 1-year result was satisfactory in 100% of women.…”

Section: Examples Of Conflict Of Interest In Plastic Surgerymentioning

confidence: 99%

“…34 The authors report that 100% of participating surgeons preferred to use mesh in all patients and the 1-year result was satisfactory in 100% of women. 33 Such publications encourage plastic surgeons to adopt commercially driven practice patterns. A recent Continuing Medical Education article suggests that mesh support represents a paradigm shift.…”

Section: Examples Of Conflict Of Interest In Plastic Surgerymentioning

confidence: 99%

“…Conflicted author/investors frequently publish photographs that are not standardized in an effort to demonstrate a therapeutic benefit. 33,36,39,40 A recent corporate-funded study on facial radiofrequency treatments with micro-needles was co-authored by a shareholder. 39 The authors magnified the preoperative photograph of a nasolabial crease 58% to make it appear larger before treatment.…”

Section: Examples Of Conflict Of Interest In Plastic Surgerymentioning

confidence: 99%

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A Discussion of Conflicts of Interest in Plastic Surgery and Possible Remedies

Swanson¹,

Brown²

2018

Plastic and Reconstructive Surgery - Global Open

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Robust Electrospun Nanofibers from Chemosynthetic Poly(4‐hydroxybutyrate) as Artificial Dural Substitute

Sun

Tang

et al. 2021

Macromolecular Bioscience

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Bioresorbable poly(4-hydroxybutyrate) (P4HB) may fulfill the specific requirements that are necessary for a dural substitute, including its high elasticity, long-term strength retention properties, and the biocompatibility without significant accumulation of acidic degradation products. However, commercial P4HB can only be produced by the bacterial fermentation, which limits its applications in the cerebrospinal system due to higher endotoxin restriction. Meanwhile, P4HB can be prepared via the ring-opening polymerization of -butyrolactone. In this contribution, high molecular weight P4HB from chemosynthesis is electrospun into fibrous membrane, showing good mechanical properties that match the natural dura mater. Such P4HB membrane induces fast cellular migration, adhesion, and proliferation of fibroblasts in vitro. Subcutaneous implantation in rats demonstrates excellent biocompatibility of the P4HB membrane with proper biodegradation behaviors. After implantation in the rabbit dural defect model as an onlay graft, the P4HB membranes prevent cerebrospinal fluid leakage and regenerate dura tissue without detecting any local or systematic infections or foreign body responses. Thus, the electrospun P4HB membranes may be particularly useful as artificial dural substitutes to induce wound closure and tissue regeneration, which will be of great benefit to neurosurgery in the future.

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The Use of Poly-4-Hydroxybutyrate (P4HB) Scaffold in the Ptotic Breast: A Multicenter Clinical Study

Cited by 26 publications

References 20 publications

Photometric Evaluation of Long-term Changes in Breast Shape after Breast Augmentation and Vertical Mammaplasty

Photometric Evaluation of Long-term Changes in Breast Shape after Breast Augmentation and Vertical Mammaplasty

A Discussion of Conflicts of Interest in Plastic Surgery and Possible Remedies

Robust Electrospun Nanofibers from Chemosynthetic Poly(4‐hydroxybutyrate) as Artificial Dural Substitute

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