The use of platelet-rich plasma in studies with early knee osteoarthritis versus advanced stages of the disease: a systematic review and meta-analysis of 31 randomized clinical trials

Vílchez-Cavazos, Félix; Blázquez-Saldaña, Jaime; Gamboa-Alonso, Augusto; Peña-Martínez,; Acosta-Olivo, Carlos; Sánchez‐García, Adriana; Simental‐Mendía, Mario

doi:10.22541/au.161951864.48874990/v1

Cited by 3 publications

(1 citation statement)

References 51 publications

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“…Maturity affects Knee OA incidence, which occurs in most elderly and older adults. In addition, Knee OA is the main factor in people in their middle and later years who experience knee joint discomfort or impairment (Vilchez-Cavazos et al, 2023). The frequency of Knee OA incidents is rising along with the population's gradually increasing life expectancy, placing a significant financial strain on the exposed healthcare and medical services.…”

Section: Introductionmentioning

confidence: 99%

Platelet-rich plasma treatment for knee osteoarthritis: A systematic investigation

Gangadharan,

Satapathy,

Dixit

et al. 2024

Multidiscip. Rev.

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According to indicates, “platelet-rich plasma (PRP)” is efficient, including secure biological technique for handling knee “osteoarthritis (OA)." Considering the number of injections necessary to see the beneficial impact, however, an agreement has yet to be reached. The therapeutic effectiveness of a single PRP injection versus numerous injections in "randomized controlled trials (RCTs)" for OA knee. To examine the impact of single vs. many treatments of PRP for suffering and functioning in patients with knee OA, extensive searching was done for RCTs published between 1970 and 2019. The information systems “MEDLINE, Scopus, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials” were searched. Data on patients, interventions, comparisons, and meaningful outcomes were collected using a data extraction tool to contain research bibliographic material. The statistics regarding the immediate results were combined using a random effects framework. With a low-moderate risk of bias and 301 patient reports, we considered clinical studies. Six months following the treatment, a synthesis revealed no substantial variations between solo and repeated injections about suffering relief standardized, average variance. The effectiveness of the knee significantly improved after numerous injections. The considerable boost was only discernible for the outcomes of solo vs. multiple pills, according to a sub-analysis. Our findings showed that a single PRP injection was just as successful in reducing inflammation as numerous treatments. However, after six months, several therapies appeared more beneficial than a single injection in improving joint functioning. The available data still needs to be improved, and further study on this subject is necessary to support our findings.

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Section: Introductionmentioning

confidence: 99%

Platelet-rich plasma treatment for knee osteoarthritis: A systematic investigation

Gangadharan,

Satapathy,

Dixit

et al. 2024

Multidiscip. Rev.

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Chondroprotective Effects of 4,5-Dicaffeoylquinic Acid in Osteoarthritis through NF-κB Signaling Inhibition

et al. 2022

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Osteoarthritis (OA) is characterized by cartilage degradation, inflammation, and pain. The dicaffeoylquinic acid (diCQA) isomer, 4,5-diCQA, exhibits antioxidant activity and various other health-promoting benefits, but its chondroprotective effects have yet to be elucidated. In this study, we aimed to investigate the chondroprotective effects of 4,5-diCQA on OA both in vitro and in vivo. Primary rat chondrocytes were pre-treated with 4,5-diCQA for 1 h before stimulation with interleukin (IL)-1β (5 ng/mL). The accumulation of nitrite, PGE2, and aggrecan was observed using the Griess reagent and ELISA. The protein levels of iNOS, COX-2, MMP-3, MMP-13, ADMATS-4, MAPKs, and the NF-κB p65 subunit were measured by Western blotting. In vivo, the effects of 4,5-diCQA were evaluated for 2 weeks in a destabilization of the medial meniscus (DMM)-surgery-induced OA rat model. 4,5-diCQA significantly inhibited IL-1β-induced expression of nitrite, iNOS, PGE2, COX-2, MMP-3, MMP-13, and ADAMTS-4. 4,5-diCQA also decreased the IL-1β-induced degradation of aggrecan. It also suppressed the IL-1β-induced phosphorylation of MAPKs and translocation of the NF-κB p65 subunit to the nucleus. These findings indicate that 4,5-diCQA inhibits DMM-surgery-induced cartilage destruction and proteoglycan loss in vivo. 4,5-diCQA may be a potential therapeutic agent for the alleviation of OA progression. In this study, diclofenac was set to be administered once every two days, but it showed an effect on OA. These results may be used as basic data to suggest a new dosing method for diclofenac.

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Functional Outcome in Early Osteoarthritis of Knee With Two Doses of Platelet Rich Plasma Our Experience.

R¹,

Manikumar

Kumar

2021

IJAR

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Background: Osteoarthritis (OA) is a degenerative disorder of synovial joints in which there is gradual softening and disintegration of articular cartilage accompanied by the new growth of cartilage and bone at the joint margins(Osteophytes), cyst formation and sclerosis in the subchondral bone, mild synovitis, and capsular brosis. It differs from simple wear and tears in that it is asymmetrically distributed, often localized to only one part of a joint i.e., weight bearing, and often associated with abnormal loading rather than frictional wear. It is a dynamic phenomenon and shows features of both destruction and repair. Cartilage softening and disintegration are accompanied from the very outset by hyperactive new bone formation, osteophyte formation and remodeling. Osteoarthritis is an age-related phenomenon, and it affects more than 80% of people greater than 55 years of age. Body mass index (BMI) plays a vital role in osteoarthritis in weight-bearing joints. People with obese or overweight were approximately 4.6 times more likely to have knee OA than normalweight individuals. In addition people with metabolic and endocrine disorders are also more prone for osteoarthritis at an early age. Methods: Sixty patients suffering from grade1and 2 osteoarthritis knee joint who attended the outpatient department of orthopaedics, King George hospital, Visakhapatnam between November 2018 to October 2020 were included in the study. Informed and written consent was taken from the patients. General physical examination was done. Neurovascular status of both lower limbs was also examined. X-ray of both knee joints in antero-posterior and lateral views were taken in standing position. Routine pre-injection WOMAC and VAS score were recorded. Under aseptic conditions, two platelet-rich plasma (PRP) injections were injected into the knee joint at four weeks interval. Functional status of the knee was evaluated using WOMAC and VAS score at one, three and six week's interval. This study is a anlyticl comparative study. Results: There is a signicant difference in the VAS score and WOMAC score before giving an injection and after giving an injection, in patients with grade 1 and grade 2 osteoarthritis. The visual analogue score showed a mean of 7.16 at pre-injection period, which decreased to 5.95 at 1st week and 4.81 at 3rd week and 4.06 at six weeks follow up. Conclusion: In the present study the effectiveness of two aliquots of PRP injection was evaluated. Although studies including more than 2 PRP injections and more advanced stages of osteoarthritis were compared, the time frame was xed to 6 weeks. The functional outcome of the patient was better after 2nd dose of PRP. The present study concluded that two doses of PRP injection decreases the joint pain, alleviates the symptoms and enhances the activity of daily living and quality of life in short term duration.

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The use of platelet-rich plasma in studies with early knee osteoarthritis versus advanced stages of the disease: a systematic review and meta-analysis of 31 randomized clinical trials

Cited by 3 publications

References 51 publications

Platelet-rich plasma treatment for knee osteoarthritis: A systematic investigation

Platelet-rich plasma treatment for knee osteoarthritis: A systematic investigation

Chondroprotective Effects of 4,5-Dicaffeoylquinic Acid in Osteoarthritis through NF-κB Signaling Inhibition

Functional Outcome in Early Osteoarthritis of Knee With Two Doses of Platelet Rich Plasma Our Experience.

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